Phenotypic Dichotomy Following Developmental Exposure to Perfluorooctanoic Acid (PFOA) in Female CD-1 Mice: Low Doses Induce Elevated Serum Leptin and Insulin, and Overweight in Mid-life☆☆

Hines, Erin P., White, Sally S., Stanko, Jason P., Gibbs-Flournoy, Eugene A., Lau, Christopher, Fenton, Suzanne E.·2009·Molecular and Cellular Endocrinology

Cited by (284)

Items 201–284 of 284

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  12. Incorporation of fetal and child PFOA dosimetry in the derivation of health-based toxicity values
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  13. Perfluorinated chemicals 2008: PFAA Days II meeting report and highlights
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  14. Kinetics and Quantitative Structure—Activity Relationship Study on the Degradation Reaction from Perfluorooctanoic Acid to Trifluoroacetic Acid
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  16. Early environmental exposures and life-long risk of chronic non-respiratory disease
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  17. Advancing the understanding of PFAS-induced reproductive toxicity in key model species
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  18. Perfluorinated Compounds in Food Contact Materials
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  19. Association between perfluoroalkyl and polyfluoroalkyl substances exposure and fetal overgrowth: A prospective birth cohort study conducted in China
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  24. Endocrine Disrupting Chemicals, Transgenerational Epigenetics and Metabolic Diseases.
    Aliya G. Feroe, Richard D. Broene, David Albuquerque, Patricia Ruiz · 2017 · PubMed
  25. Food contaminants and programming of type 2 diabetes: recent findings from animal studies
    Stéphane Firmin, Nargès Bahi-Jaber, Latifa Abdennebi‐Najar · 2016 · Journal of Developmental Origins of Health and Disease
  26. Effects of PFOA on Endocrine-Related Systems
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  27. Lessons Learned from Legacy Contaminants of Emerging Concern: Perfluoroalkyl Compounds (PFCs) in the Village of Hoosick Falls, Rensselaer County, New York
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  28. Adipose tissue accumulation of endocrine disrupting compounds: Variant of a common theme in exposome research
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  29. A new alternative method using cyp3a65 expression in transgenic zebrafish embryos to assess metabolic endocrine-disrupting chemicals in the intestine
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  32. Endocrine Disruptors as Obesogens
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    Jerrold J. Heindel · 2019 · Current topics in environmental health and preventive medicine
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  43. Radiosynthesis of Perfluoroalkyl Substances : Chemical analysis, uptake, distribution, and partitioning studies
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  44. Retraction. Prenatal PFOA exposure alters gene expression pathways in murine mammary gland.
    Madisa B. Macon, H. Ren, S. Fenton · 2014 · Toxicological Sciences · Retracted
  45. Evaluation of Prenatal Exposure to Bisphenol Analogues on Development and Long-Term Health of the Mammary Gland in Female Mice
    National Toxicology Program (NTP) · 2019 · Chemical Effects in Biological Systems (CEBS)
  46. Toxicity and Health Risks of PFAS
    Chathura Dhanasinghe, Wei‐Zhe Lin, Chih‐Ming Kao, Rao Y. Surampalli, Tian C. Zhang · 2025 · Wiley eBooks
  47. Report of the Scientific Committee of the Spanish Agency for Food Safety and Nutrition (AESAN) on the available evidence in relation to the potential obesogenic activity of certain chemical compounds that may be present in foods
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  48. Associations of pre- and postnatal per- and polyfluoroalkyl substance exposure with adolescents’ eating behaviors
    Taylor-Marie Vasil, Elvira S. Fleury, Erica Walker, Jordan R. Kuiper, Jessie Poulin Buckley, Kim M. Cecil, Aimin Chen, Heidi J. Kalkwarf, Bruce Perrin Lanphear, Kimberly A. Yolton et al. · 2024 · Environmental Epidemiology
  49. Perfluorooctanoic acid disrupts hepatic metabolism in the developing chicken embryo
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  50. Developmental Exposure to Endocrine Disrupting Chemicals: Is There a Connection with Birth and Childhood Weights?
    Elizabeth Elliott Hatch, Jessica W. Nelson, Rebecca J. Troisi, Linda J Titus · 2011 · Humana Press eBooks
  51. Health Consequences Due to Prenatal Endocrine-Disrupting Chemical Exposure
    Jayshree Annamalai, Namasivayam Vasudevan · 2017 · Springer eBooks
  52. Role of Perfluoroalkyl Substances as EDCs in Metabolic Disorders
    Samia Gul Niazi, Chanda Javed, Adeel Shah, Qurat Ul Ain, Imtiaz Mahmood Tahir · 2020 · Emerging contaminants and associated treatment technologies
  53. Impact of Environmental Obesogens
    Michael I. Goran · 2016 · CRC Press eBooks
  54. Activators of PPAR, RXR, AR, and Steroidogenic Factor 1
    2014
  55. Environmental Contaminants and Obesity
    Monika Rönn · 2013 · KTH Publication Database DiVA (KTH Royal Institute of Technology)
  56. Tissue distribution studies and risk assessment of perfluoroalkylated and polyfluoroalkylated substances (pfass)
    Daniel Borg · 2013 · Figshare
  57. Development of in vitro test methods in a model of human pancreatic β-cells to identify metabolism disrupting chemicals with diabetogenic activity
    Reinaldo Sousa dos Santos, Regla M. Medina-Gali, Ignacio Babiloni-Chust, Laura Marroquí, Ángel Nadal · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  58. Faculty Opinions recommendation of Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population.
    David Taylor, Jamie C. DeWitt · 2010 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  59. Mammary Gland as a Sensitive Tissue to Developmental Exposures of Perfluorooctanoic Acid (PFOA) in the Mouse
    Sally S. White, Suzanne E. Fenton, Chengfeng Yang, Sandra Z. Haslam · 2011 · Springer eBooks
  60. EFFECTS OF PERFLUORINATED COMPOUNDS (PFCs) ON METABOLIC TISSUES AND THE BENEFITS OF CALORIC RESTRICTION
    Deanna M. Salter · 2015
  61. Effects of Perfluorinated Compounds on GnRH Gene Expression in vitro
    Rebecca E. Bathke · 2009
  62. PFAA Days III meeting report and highlights
    Christopher S. Lau, Andrew B. Lindstrom, Toni Krasnic · 2012 · Reproductive Toxicology
  63. Letter RE: Derivation of a Drinking Water Equivalent Level (DWEL) Related to the Maximum Contaminant Level Goal for Perfluorooctanoic Acid (PFOA), a Persistent Water Soluble Compound
    Keith R. Cooper · 2010 · Food and Chemical Toxicology
  64. Radiosynthesis of Perfluoroalkyl Substances
    Maria Sundström · 2012
  65. Obesogens and Nuclear Receptors
    Gülşen GÖNEY · 2017 · Journal of Applied Biotechnology & Bioengineering
  66. Noticias de salud ambiental EHP-SPM
    2012 · Salud Pública de México
  67. EVALUATION OF KEY PERFLUOROALKYL SUBSTANCES TO INDUCE LIVER STEATOSIS IN MOUSE AND HUMAN MODELS
    Emily Marques · 2020
  68. Comments on the Draft ATSDR Toxicologic Profile on Perfluoroakyls: Assessment of Epidemiological Studies
    Perry D. Cohn · 2009
  69. Additional file 4 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Chiara Matilde Ferrari, Silvia Fustinoni · 2023 · Figshare
  70. Additional file 3 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Ferrari, Chiara Matilde, Silvia Fustinoni · 2023 · Figshare
  71. Additional file 8 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Ferrari, Chiara Matilde, Silvia Fustinoni · 2023 · Figshare
  72. Additional file 5 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Chiara Matilde Ferrari, Silvia Fustinoni · 2023 · Figshare
  73. Additional file 6 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Ferrari, Chiara Matilde, Silvia Fustinoni · 2023 · Figshare
  74. Additional file 7 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Ferrari, Chiara Matilde, Silvia Fustinoni · 2023 · Figshare
  75. Additional file 9 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Gianfranco Frigerio, Chiara Matilde Ferrari, Silvia Fustinoni · 2023 · Figshare
  76. Additional file 2 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Frigerio, Gianfranco, Chiara Matilde Ferrari, Silvia Fustinoni · 2023 · Figshare
  77. Additional file 1 of Per- and polyfluoroalkyl substances (PFAS) and neurobehavioral function and cognition in adolescents (2010–2011) and elderly people (2014): results from the Flanders Environment and Health Studies (FLEHS)
    van Larebeke, Nicolas, Koppen Gudrun, Sam De Craemer, Ann Colles, Liesbeth M. Bruckers, Den Hond, Elly, Govarts, Eva, Bert Morrens, Thomas Schettgen, Sylvie Rémy et al. · 2022 · Figshare
  78. Additional file 1 of Prenatal and childhood exposure to per-/polyfluoroalkyl substances (PFASs) and its associations with childhood overweight and/or obesity: a systematic review with meta-analyses
    Frigerio, Gianfranco, Chiara Matilde Ferrari, Silvia Fustinoni · 2023 · Figshare
  79. Identification of pharmaceuticals and environmental contaminants as obesogens inducing a locomotion-independent thrifty phenotype
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  82. Per- and polyfluoroalkyl substances are associated with gestational diabetes and perturb hepatic metabolic regulatory networks: Convergent epidemiological, computational, and experimental evidence.
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    Bojung Seo, Ana Claudia Maretti-Mira, Hongxu Wang, Chikako Matsuba, Joseph D. Romano, Ye Ji Choi, Hailey E Hampson, Matthew P. Salomon, Laura L. Pyle, Max T. Aung et al. · 2026 · Next research.
  84. Effects of Dibutylphthalate on the Biosynthesis of Intermediates of the Androgen and Glucocorticoid Pathway in a Cultured Rat Leydig Cell Line (R2C)
    Adam Daniel Ridden · 2013 · UC Research Repository (University of Canterbury)