Inflammatory pathways in endometrial disorders
Abstract
Complex interactions between the endocrine and immune systems govern the key endometrial events of implantation and menstruation. In contrast to other tissue sites, cyclical endometrial inflammation is physiological. However, dysregulation of this inflammatory response can lead to endometrial disorders. This review examines the inflammatory processes occurring in the normal endometrium during menstruation and implantation, highlighting recent advances in our understanding and gaps in current knowledge. Subsequently, the role of inflammatory pathways in the pathology of various common endometrial conditions is discussed, including heavy menstrual bleeding, dysmenorrhoea (painful periods), uterine fibroids, endometriosis and recurrent miscarriage.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Dysregulation of cyclical endometrial inflammatory response can lead to endometrial disorders, including endometriosis.
“However, dysregulation of this inflammatory response can lead to endometrial disorders, including endometriosis.61”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [61]
IL-6, IL-10, IFN, and TGF-b are implicated in immune and inflammatory responses in the pathogenesis of endometriosis.
“Interleukin (IL)-6, IL-10, interferon (IFN), and transforming growth factor (TGF-b) are implicated in the immune and inflammatory responses in the pathogenesis of endometriosis.61,64”
From Defining Future Directions for Endometriosis Research: Workshop Report From the 2011 World Congress of Endometriosis in Montpellier, France (2013) · cites this paper as [61]
The citation lists haven’t been fetched yet
References 139 · Cited by 170
- Authors
- Maybin, J. A., Critchley, H. O. D., & Jabbour, H. N.
- Affiliations
- The Queen's Medical Research Institute (GB)
- Corresponding author
- Jabbour, Henry N.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2011-03
- Volume
- 335
- Issue
- 1
- Pages
- 42-51
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2075846272
- Cited by
- 170
- References
- 139
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 6 · 2023: 8 · 2022: 8 · 2021: 13 · 2020: 14 · 2019: 7 · 2018: 12 · 2017: 13 · 2016: 12 · 2015: 7 · 2014: 9 · 2013: 17 · 2012: 16
- FWCI
- 0.92
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MRC (G0600048, U.1276.00.004.00002.01)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Menstrual Health and Disorders
- Keywords
- endometritis, endometrial pathology, implantation, menstruation, endocrine-immune interaction, menorrhagia, dysmenorrhea, uterine fibroids, endometriosis, recurrent pregnancy loss, inflammatory signaling
- MeSH terms
- Abortion, Habitual, Animals, Decidua, Dysmenorrhea, Endometriosis, Endometrium, Female, Humans, Inflammation, Leiomyoma, Leukocytes, Menstruation, Embryo Implantation, Pregnancy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
