Metformin and resveratrol inhibit Drp1-mediated mitochondrial fission and prevent ER stress-associated NLRP3 inflammasome activation in the adipose tissue of diabetic mice

Li, Aiyun, Zhang, Shuihong, Li, Jia, Liu, Kang, Huang, Fang, Liu, Baolin·2016·Molecular and Cellular Endocrinology

DOI 10.1016/j.mce.2016.06.008

Cited by (197)

Items 101–197 of 197

The anti-periodontitis action of metformin via targeting NLRP3 inflammasome
Yongmei Tan, Jinsu Chen, Yingtong Jiang, Chen Xie, Jingmei Li, Bining Chen, Jie Gao · 2020 · Archives of Oral Biology
Nutrigenomic Effects of Long-Term Grape Pomace Supplementation in Dairy Cows
Marianna Pauletto, Ramy Elgendy, Andrea Ianni, Elettra Marone, Mery Giantin, Lisa Grotta, Solange Ramazzotti, Francesca Bennato, Mauro Dacasto, Giuseppe Martino · 2020 · Animals
Modulatory Effect of Intermittent Fasting on Adipose Tissue Inflammation: Amelioration of Cardiovascular Dysfunction in Early Metabolic Impairment
Haneen S. Dwaib, Ibrahim AlZaim, Ali Hussein Eid, Omar Obeid, Ahmed Fawzy EL‐Yazbi · 2021 · Frontiers in Pharmacology
The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes
Shuang-Yu Lv, Xiao-Tian Li, Hong-Gang Wang · 2021 · Frontiers in Cell and Developmental Biology
AMPK: Potential Therapeutic Target for Vascular Calcification
Yi Lü, Tan Yuan, Xinjia Min, Zhen Yuan, Zhejun Cai · 2021 · Frontiers in Cardiovascular Medicine
Mitochondrial oxidative phosphorylation is dispensable for survival of CD34+ chronic myeloid leukemia stem and progenitor cells
Jinsong Yan, Meng‐Ying Yang, Xuehong Zhang, Chen‐Hui Luo, Cheng-Kan DU, Yue Jiang, Xuan-Jia Dong, Zhang-Man Wang, Lixue Yang, Yi-Dong Li et al. · 2022 · Cell Death and Disease
Inhalational supplementation of metformin butyrate: A strategy for prevention and cure of various pulmonary disorders
Kunal Maniar, Vandana Singh, Amal Moideen, Rajasri Bhattacharyya, Amitava Chakrabarti, Dibyajyoti Banerjee · 2018 · Biomedicine & Pharmacotherapy
Skimmin protects diabetic cardiomyopathy in streptozotocin‐induced diabetic rats
Rui‐Kai Liang, Yun‐Yun Zhao, Mei‐Li Shi, Gang Zhang, Yong‐Jun Zhao, Bing‐Gui Zhang, Rui‐Jing Liang · 2020 · The Kaohsiung Journal of Medical Sciences
The Imbalance of Mitochondrial Fusion/Fission Drives High-Glucose-Induced Vascular Injury
Yunsi Zheng, Anqi Luo, Xiaoquan Liu · 2021 · Biomolecules
Natural products as pharmacological modulators of mitochondrial dysfunctions for the treatment of diabetes and its complications: An update since 2010
Qianru Lin, Lianqun Jia, Ming Lei, Di Gao, Nan Zhang, Lei Sha, Xuhan Liu, Yudan Liu · 2024 · Pharmacological Research
Resveratrol Attenuates CSF Markers of Neurodegeneration and Neuroinflammation in Individuals with Alzheimer’s Disease
Xiaoguang Liu, Sean Baxley, Michaeline L. Hebron, Raymond Scott Turner, Charbel Moussa · 2025 · International Journal of Molecular Sciences
Resveratrol Can Attenuate Astrocyte Activation to Treat Spinal Cord Injury by Inhibiting Inflammatory Responses
Ruihua Fan, Yong Zhang, Benson O. A. Botchway, Xuehong Liu · 2021 · Molecular Neurobiology
Panax notoginseng saponin R1 attenuates allergic rhinitis through AMPK/Drp1 mediated mitochondrial fission
Yalin Zhang, Yilan Song, Chongyang Wang, Jingzhi Jiang, Siqi Liu, Qiaoyun Bai, Liangchang Li, Hainan Jin, Yongde Jin, Guanghai Yan · 2022 · Biochemical Pharmacology
Nicotinic acid inhibits NLRP3 inflammasome activation via SIRT1 in vascular endothelial cells
Yanxiang Li, Guangde Yang, Xiaofeng Yang, Weirong Wang, Jiye Zhang, Yanhao He, Wei Zhang, Ting Jing, Rong Lin · 2016 · International Immunopharmacology
Mitochondrial Dynamics: In Cell Reprogramming as It Is in Cancer
Javier Prieto, Josema Torres · 2017 · Stem Cells International
Miquelianin in folium Nelumbinis extract promotes white-to-beige fat conversion via blocking AMPK/DRP1/mitophagy and modulating gut microbiota in HFD-fed mice
Wang, Zhenyu, Yang, Tian, Zeng, Maomao, Wang, Zhaojun, Chen, Qiuming, Chen, Jie, Christian, Mark, He, Zhiyong · 2023 · Food and Chemical Toxicology
AMPK as a potential pharmacological target for alleviating LPS-induced acute lung injury partly via NLRC4 inflammasome pathway inhibition
Yuting He, Kan Xu, Yao Wang, Xin Chao, Binger Xu, Jiayu Wu, Jiping Shen, Weiying Ren, Yu Hu · 2019 · Experimental Gerontology
Reprogramming Macrophage Metabolism and its Effect on NLRP3 Inflammasome Activation in Sepsis
Ruiheng Luo, Xizhe Li, Dan Wang · 2022 · Frontiers in Molecular Biosciences
Pharmacological landscape of endoplasmic reticulum stress: Uncovering therapeutic avenues for metabolic diseases
Ghallab Alotaibi, Abdullah Alkhammash · 2025 · European Journal of Pharmacology
The Role of NLRP3 Inflammasome in Type 2 Diabetes Mellitus and Its Macrovascular Complications
Konstantinos Karamitsos, Evangelos K. Oikonomou, Panagiotis Theofilis, Ignatios Ikonomidis, Eva N. Kassi, Vaia Lambadiari, ELIAS J. GIALAFOS, Aikaterini Tsatsaragkou, Vasiliki Chara Mystakidi, Konstantinos Zisimos et al. · 2025 · Journal of Clinical Medicine
Atherosclerosis as Mitochondriopathy: Repositioning the Disease to Help Finding New Therapies
Taisiia S. Shemiakova, Ekaterina A. Ivanova, Wei‐Kai Wu, Tatiana Vladimirovna Kirichenko, Antonina Vladimirovna Starodubova, Alexander Nikolaevich Orekhov · 2021 · Frontiers in Cardiovascular Medicine
Diabetes Mellitus and Cardiovascular Diseases: Nutraceutical Interventions Related to Caloric Restriction
Pamela Senesi, Anna Ferrulli, Livio Luzi, Ileana Terruzzi · 2021 · International Journal of Molecular Sciences
Therapy Targeted to the NLRP3 Inflammasome in Chronic Kidney Disease
Yong Ji, Hua Hu, Zhanjun Jia, Aihua Zhang, Guixia Ding · 2024 · Kidney Diseases
Mitochondrial dysfunction in diabetic neuropathy: Impaired mitophagy triggers NLRP3 inflammasome
Keshari Kumar Sriwastawa, Ashutosh Kumar · 2024 · Mitochondrion
Models and Molecular Mechanisms of World Health Organization Group 2 to 4 Pulmonary Hypertension
Ping Yu Xiong, François Potus, Winnie W. Y. Chan, Stephen L. Archer · 2017 · Hypertension
Swine Influenza Virus Induces RIPK1/DRP1-Mediated Interleukin-1 Beta Production
Hong-Su Park, Guanqun Liu, Qiang Liu, Yan Zhou · 2018 · Viruses
Cold stress causes liver damage by inducing ferroptosis through the p38 MAPK/Drp1 pathway
Yujie Huang, Kun Xiong, Aiping Wang, Zejun Wang, Qi Cui, Hongchen Xie, Tian Yang, Fan Xu, Wenjun Jiang, Xiaoling Tan et al. · 2023 · Cryobiology
Metformin promotes osteogenic differentiation and prevents hyperglycaemia-induced osteoporosis by suppressing PPARγ expression
Lifeng Zheng, Ximei Shen, Yun Xie, Hong Lian, Sunjie Yan, Shizhong Wang · 2023 · Acta Biochimica et Biophysica Sinica
Novel insights into the role of mitochondria in diabetic cardiomyopathy: molecular mechanisms and potential treatments
Fumin Zhi, Qian Zhang, Li Liu, Xing Chang, Hongtao Xu · 2023 · Cell Stress and Chaperones
Can nutritional interventions modulate the activation of the NLRP3 inflammasome in chronic kidney disease?
Lívia Alvarenga, L. Cardozo, Natália Alvarenga Borges, Bengt Lindholm, Peter Stenvinkel, Paul G. Shiels, Denis P. Fouque, Denise Mafra · 2020 · Food Research International
The Causal Role of Mitochondrial Dynamics in Regulating Innate Immunity in Diabetes
Yen‐Hsiang Chang, Hung‐Yu Lin, Feng‐Chih Shen, Yu‐Jih Su, Jiin‐Haur Chuang, Tsu‐Kung Lin, Chia‐Wei Liou, Ching‐Yi Lin, Shao‐Wen Weng, Pei‐Wen Wang · 2020 · Frontiers in Endocrinology
Ginsenoside Rg1 alleviates lipopolysaccharide-induced pyroptosis in human periodontal ligament cells via inhibiting Drp1-mediated mitochondrial fission
Kefei Chu, Zhenghao Zhang, Yi Chu, Yao Xu, Wanrong Yang, Ling Guo · 2023 · Archives of Oral Biology
Dl-3-n-butylphthalide attenuates cerebral ischemia/reperfusion injury in mice through AMPK-mediated mitochondrial fusion
Ting Zhu, Shanshan Dong, Na Qin, Ru‐Juan Liu, Liuliu Shi, Qi Wan · 2024 · Frontiers in Pharmacology
Three‐dimensional electron microscopy techniques for unravelling mitochondrial dysfunction in heart failure and identification of new pharmacological targets
Hussam Daghistani, Bodour S. Rajab, Ashraf Kitmitto · 2018 · British Journal of Pharmacology
N-acetylcysteine alleviates fluoride-induced testicular apoptosis by modulating IRE1α/JNK signaling and nuclear Nrf2 activation
Yazhen Hu, Yawei Wang, Ting Yan, Demin Feng, Yue Ba, Huizhen Zhang, Jingyuan Zhu, Xuemin Cheng, Liuxin Cui, Hui Huang · 2019 · Reproductive Toxicology
Chemoprevention of obesity by dietary natural compounds targeting mitochondrial regulation
Ching‐Shu Lai, Jia-Ching Wu, Chi‐Tang Ho, Min‐Hsiung Pan · 2016 · Molecular Nutrition & Food Research
Roles of AMPK and Its Downstream Signals in Pain Regulation
Shenglan Wang, Yi Dai · 2021 · Life
Ghrelin inhibits myocardial pyroptosis in diabetic cardiomyopathy by regulating ERS and NLRP3 inflammasome crosstalk through the PI3K/AKT pathway
Fan Wang, Jingzhi Wang, Xinfang Liang, Zixuan Wu, Jiaxin Xue, Lingyu Yin, Lai Wei, Xiaohui Zhang · 2023 · Journal of drug targeting
Activation of the IRE1α Arm, but not the PERK Arm, of the Unfolded Protein Response Contributes to Fumonisin B1-Induced Hepatotoxicity
Xiaoyi Liu, Enxiang Zhang, Shutao Yin, Chong Zhao, Lihong Fan, Hongbo Hu · 2020 · Toxins
Nutraceutical Compounds Targeting Inflammasomes in Human Diseases
Beatriz Castejón‐Vega, Francesca Giampieri, José M. Álvarez-Suárez · 2020 · International Journal of Molecular Sciences
Molecular Characterization and Elucidation of Pathways to Identify Novel Therapeutic Targets in Pulmonary Arterial Hypertension
Xiaoting Yao, Jing Yun Tian, Tianxing Wang, Chenxin Gu, Xi Chen, Fengqiang Chen, Hao Feng, Huiying Zhao, Dekun Chen, Wentao Ma · 2021 · Frontiers in Physiology
Mangiferin Inhibits PDGF‐BB‐Induced Proliferation and Migration of Rat Vascular Smooth Muscle Cells and Alleviates Neointimal Formation in Mice through the AMPK/Drp1 Axis
Qi Wu, Yuanyang Chen, Zhiwei Wang, Xin Cai, Yanjia Che, Sihao Zheng, Shun Yuan, Xiaohan Zhong · 2021 · Oxidative Medicine and Cellular Longevity
Metformin Overcomes the Consequences of NKX3.1 Loss to Suppress Prostate Cancer Progression
Papachristodoulou, Alexandros, Heidegger, Isabel, Virk, Renu K., Di Bernardo, Matteo, Kim, Jaime Y., Laplaca, Caroline, Picech, Florencia, Schäfer, Georg, De Castro, Guarionex Joel, Hibshoosh, Hanina et al. · 2024 · European Urology
From sunscreens to medicines: Can a dissipation hypothesis explain the beneficial aspects of many plant compounds?
Alistair V.W. Nunn, Geoffrey W. Guy, Stanley W. Botchway, Jimmy David Bell · 2020 · Phytotherapy Research
Selenomethionine alleviates kidney necroptosis and inflammation by restoring lipopolysaccharide-mediated mitochondrial dynamics imbalance via the TLR4/RIPK3/DRP1 signaling pathway in laying hens
Xinzhang Chen, Yixuan Wang, Muyue Zhang, Yongzhen Du, Yujiao He, Shu Li · 2024 · Poultry Science
Endoplasmic reticulum stress-dependent activation of TRB3-FoxO1 signaling pathway exacerbates hyperglycemic nephrotoxicity: Protection accorded by Naringenin
Mohammad Fareed Khan, Alpana Mathur, Vivek Kumar Pandey, Poonam Kakkar · 2022 · European Journal of Pharmacology
Microvesicle-transferred mitochondria trigger cGAS-STING and reprogram metabolism of macrophages in sepsis
Ting Ji, Tingting Zhao, Sheng-Ze Long, Cai-Zhou Wei, Deyun Cheng, Juan Chen, Liangjian Kuang · 2025 · Microbiology Spectrum
Adipose tissue mitochondrial dysfunction and cardiometabolic diseases: On the search for novel molecular targets
Ibrahim AlZaim, Ali Hussein Eid, Khaled S. Abd‐Elrahman, Ahmed Fawzy EL‐Yazbi · 2022 · Biochemical Pharmacology
Proteostasis in epicardial versus subcutaneous adipose tissue in heart failure subjects with and without diabetes
Ana Burgeiro, Ana C. Fonseca, Daniel Espinoza, Lina Carvalho, Nuno Lourenço, M. Antunes, Eugénia Carvalho · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Analysis of Inflammatory Gene Expression Profile of Peripheral Blood Leukocytes in Type 2 Diabetes
Humera Inayat, M. Kamran Azim, Akhter Ali Baloch · 2019 · Immunological Investigations
How to Restore Oxidative Balance That Was Disrupted by SARS-CoV-2 Infection
Kajetan Kiełbowski, Mariola Herian, Andrzej Pawlik · 2022 · International Journal of Molecular Sciences
Metformin Alleviates Epirubicin-Induced Endothelial Impairment by Restoring Mitochondrial Homeostasis
Qi Long Sun, Huiling Jia, Shuo Cheng, Yujuan Wang, Jun Wang · 2022 · International Journal of Molecular Sciences
Mitophagy–NLRP3 Inflammasome Crosstalk in Parkinson’s Disease: Pathogenic Mechanisms and Emerging Therapeutic Strategies
Sahabuddin Ahmed, Tulasi Pasam, Farzana Afreen · 2026 · International Journal of Molecular Sciences
Mitophagy suppression by miquelianin‐rich lotus leaf extract induces ‘beiging’ of white fat via AMPK / DRP1‐PINK1 / PARKIN signaling axis
Zhenyu Wang, Tian Yang, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Mark Christian, Zhiyong He · 2023 · Journal of the Science of Food and Agriculture
Sulforaphane impedes mitochondrial reprogramming and histone acetylation in polarizing M1 (LPS) macrophages
Sheyda Bahiraii, Martin Brenner, Wolfram Weckwerth, Elke H. Heiß · 2024 · Free Radical Biology and Medicine
Beneficial effects of metformin supplementation in hypothalamic paraventricular nucleus and arcuate nucleus of type 2 diabetic rats
Xiao‐Jing Yu, Yanmei Chen, Xiaojing Liu, Xiaojie Bai, Kai‐Li Liu, Liyan Fu, Hong‐Li Gao, Tian-Ze Sun, Xiao‐Lian Shi, Jie Qi et al. · 2022 · Toxicology and Applied Pharmacology
NLRP3 inflammasomes pathway: a key target for Metformin
Yasamin Hosseini, Amirhossein Niknejad, Ayeh Sabbagh Kashani, Mahsa Gholami, Mahtab Roustaei, Mohammad Kazem Mohammadi, Saeideh Momtaz, Stephen Lawrence Atkin, Tannaz Jamialahmadi, Amir Hossein Abdolghaffari et al. · 2025 · Inflammopharmacology
The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasomes in the Development of Atherosclerosis
VIKTOR V. PUSHKAREV, О.I. Kovzun, О.I. Kovzun, V. M. Pushkarev, Mykola D. Tronko · 2021 · Cytology and Genetics
Ginsenoside Re binds Drp1 Leu94 across species to restore mitochondrial homeostasis via Atg1/ULK1-dependent fission-mitophagy coupling in age-related degeneration
Chenrong Jin, Juhui Qiao, Huilin Gong, Xiaorui Yu, Xinran Wang, Jiao Xi, Runying Mi, Shiting Yu, Daian Pan, Siming Wang et al. · 2025 · Pharmacological Research
Metformin Inhibits Inflammation by Targeting the NLRP3 Inflammasome: Linking NF-κB/NEK7/AMPK Signaling to Mitochondrial Function
Dingyi Ning, Chenxin Jiang, Jiangyan Zeng, Fanyun Zeng, Xuehong Zheng, Panpan Xia, Yunkun Liu, Xin Huang (11077), Deju Zhang, Xiao Liu et al. · 2026 · Journal of Inflammation Research
Targeting mitochondria: a great boon to fight type 2 diabetes
A Marañón, Susana Rovira‐Llopis, Milagros Rocha, Víctor M. Víctor · 2022 · Redox Experimental Medicine
Postprandial Triglyceride-Rich Lipoproteins-Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Inflammation in White Adipocytes
Liyuan Zhu, Liling Guo, Jin Rui Xu, Qunyan Xiang, Yangrong Tan, Feng Tian, Xiao Du, Shilan Zhang, Tie Wen, Ling Liu · 2023 · Journal of Nutrition
Single and Combined Impact of Semaglutide, Tirzepatide, and Metformin on β-Cell Maintenance and Function Under High-Glucose–High-Lipid Conditions: A Comparative Study
Esmaeel Ghasemi Gojani, Bo Wang, Dongping Li, Olga Kovalchuk, Igor Kovalchuk · 2025 · International Journal of Molecular Sciences
The pathological roles of thioredoxin-interacting protein in ischemic stroke, focusing on oxidative stress and pyroptosis
Weizhuo Lu, Zenghong Jiang, Jiyue Wen · 2025 · International Journal of Biological Macromolecules
AMPK–NLRP3 Inflammasome Crosstalk: Structural Insights, Molecular Mechanisms, and Therapeutic Implications for Inflammation and Neuroinflammation
Triveni Kodi, Krishnadas Nandakumar, Anoop Kishore · 2026 · Molecular Neurobiology
Impact of DPP-4 Inhibitors on Interleukin Levels in Type 2 Diabetes Mellitus
Yiduo Feng, Beibei Shang, Yang Yu, Donglei Zhang, Changbin Liu, Zheng Hong Qin, Yilun Zhou, Jie Meng, Xin Liu · 2024 · The Journal of Clinical Endocrinology & Metabolism
Advanced glycation end-products accelerate amyloid deposits in adipocyte’s lipid droplets
Roza Izgilov, Nadav Kislev, Eman Omari, Dafna Benayahu · 2024 · Cell Death and Disease
Novel Mitochondria-Targeted NIR Cyanine Cy750M-C1 Nanoparticles for Chemotherapy against Triple-Negative Breast Cancer
Zhilin Shen, Fenglin Zhang, Jiawang Yang, Kaihang Zhang, Feng Liang, Han Mu, Shi Li, Jijun Jiang, Yuanzhi Yang, Zhixuan Lin et al. · 2025 · ACS Biomaterials Science & Engineering
Pioglitazone Ameliorates Mitochondrial Oxidative Stress and Inflammation via AMPK ‐Dependent Inhibition of Mitochondrial Fission in Leigh Syndrome
Jie Denny Luo, Ling Chen, Xiaoxian Zhang, Qiang Su, Xiaoya Zhou, Qizhou Lian · 2025 · Cell Proliferation
Resveratrol; an inflammasome inhibitor and a potential therapy for severe cases of COVID-19
Mohammad‐Reza Mahmoudian‐Sani, Ali Saeedi‐Boroujeni, Ali Khodadadi, Sheyda Houshmandfar, Sima Tahmaseby Gandomkari, Arash Alghasi · 2021 · Immunopathologia Persa
Targeting mitochondrial metabolites and nucleic acids as an anti-inflammatory strategy
Yukun Min, Luke A.J. O'Neill · 2023 · Frontiers in Drug Discovery
Energy Provisioning and Inflammasome Activation: The Pivotal Role of AMPK in Sterile Inflammation and Associated Metabolic Disorders
Akhila Hosur Shrungeswara, Mazhuvancherry Kesavan Unnikrishnan · 2020 · Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Inhibiting Inflammasomes with Small Molecules
Avril A. B. Robertson · 2018 · Experientia supplementum
Mitochondrial Dynamics in Blood Cancer Development and Progression
Saurav Doshi, Christina Glytsou · 2025 · Current Pharmacology Reports
Approach to the Patient: Mitochondrial Diabetes: Contemporary Cases and a Precision Medicine Approach
Kaylee R Oppenheimer, Nava T Himelhoch, Michael E. McCullough, TIANA L. BOWDEN, Balamurugan Kandasamy, Lisa R. Letourneau, Rochelle N. Naylor, Siri Atma W. Greeley, Louis H. Philipson · 2025 · The Journal of Clinical Endocrinology & Metabolism
COPS3 AS lncRNA enhances myogenic differentiation and maintains fast-type myotube phenotype
Zhao Zhao He, Tiantian Zhao, Naren Qimuge, Tingting Tian, Wenyong Yan, Xudong Yi, Jianjun Jin, Rui Cai, Taiyong Yu, Gongshe Yang et al. · 2022 · Cellular Signalling
Potential Impact of Bioactive Compounds as NLRP3 Inflammasome Inhibitors: An Update
Sonia Kaur Singh, Shiwangi Sharma, Himanshu Sharma · 2024 · Current Pharmaceutical Biotechnology
Ribosome collisions and ZAKα activation: explores the therapeutic potential of metabolic diseases
Wenqiang Zhang, Kexin Zhang, Chengxia Kan, Sufang Sheng, Ningning Hou, Fang Han, Jingwen Zhang, Xiaodong Sun · 2025 · American Journal of Physiology-Endocrinology and Metabolism
A Non‐Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation
Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, HU Songhui, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen et al. · 2026 · Advanced Science
Endothelial mitochondrial homeostasis in the development and progression of atherosclerosis
Naznin Sultana Remex, Md Sakil Miah, Tamjid Islam, Richa Aishwarya, Md Hasif Sinha, Proma Dhar, Cyrine Ben Dhaou, Anthony Wayne Orr, Md. Shenuarin Bhuiyan · 2026 · Frontiers in Cardiovascular Medicine
Effects of Metformin on Modulating the Expression of Brain-related Genes of APP/PS1 Transgenic Mice based on Single Cell Sequencing
Xiao Qiu-Yue, Ye Tian-Yuan, Xiaolong Wang, Dongmei Qi, Cheng Xiao-Rui · 2022 · Current Alzheimer Research
New Insights of Punicalagin in Alleviating Diabetic Liver Injury: Inhibition of NEK7 ‐ NLRP3 via Modulating Mitochondrial Dynamics
Xiuying Tan, Rou Zhang, Yuhan Zhang, Ziyi You, Lina Yang · 2026 · Phytotherapy Research
Metformin—A Type 2 Diabetes Mellitus Drug—And Ovarian Cancer: Anticancer Mechanisms and Therapeutic Implications
Emma Sielski, Shuhd Al Noumani, Ella Bower, Kate Cunningham, Grace Beidel, Alissa Luchianova, Maria Cecilia Courreges, Fabián Benencia · 2026 · Biomolecules
Advance Glycation End-products accelerate amyloid deposits in adipocyte’s lipid droplets
Roza Izgilov, Nadav Kislev, Eman Omari, Dafna Benayahu · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
CHARACTERIZATION OF PORCINE NLRP3 INFLAMMASOME-MEDIATED INTERLEUKIN-1 BETA PRODUCTION IN RESPONSE TO INFLUENZA A VIRUSES
Hong-su Park · 2019 · HARVEST (University of Saskatchewan)
The Effects of Metformin on Obesity-Induced Diabetic Retinas
Jeesu Kim · 2017 · OakTrust (Texas A&M University Libraries)
Nutritional Regulation of Inflammation in Obesity and Diabetes
Xin Wang, Jian Liu · 2020 · Royal Society of Chemistry eBooks
Exosome derived from mesenchymal stem cells enhance autophagy and inhibit iNOS/TXNIP/NLRP3 inflammasome axis in injured spinal cord
Bin Lv, Lei Wang, Anquan Huang, Tianming Zou, Jishan Yuan · 2020
Formale oder materiale Topik? Kontroversen und Perspektiven der neueren literaturwissenschaftlichen Topik-Forschung
Ralf Boscher · 1999 · KOPS (University of Konstanz)
Immune-targeted therapies: Management of diabetes and fostering healthy aging
Firzan Nainu, Youdiil Ophinni, Sukamto Salang Mamada, Nadila Pratiwi Latada · 2026 · Elsevier eBooks
Implication du récepteur minéralocorticoïde adipeux dans les dysfonctions métaboliques et vasculaires associées à l’obésité et au syndrome métabolique : rôle des mitochondries
Clara Lefranc · 2020 · theses.fr (ABES)
Implication de TXNIP endothéliale dans la protection vasculaire lors de troubles métaboliques dans un contexte de vieillissement et conséquences dans l'accident vasculaire cérébral ischémique
Julia Jolibois · 2022 · theses.fr (ABES)
Resveratrol inhibits NLRP3 inflammasome-mediated pyroptosis to attenuate renal injury in diabetic nephropathy
Jixing ZHAO, Qiuyun DENG, Ruicheng ZHANG · 2026 · Minerva Biotechnology and Biomolecular Research
Allosteric modulation of Drp1 by natural compounds for cardiac therapeutics: a molecular docking and dynamics study
Bhavya Somalapura Gangadharappa, Keerthana Ramji · 2026 · Journal of Biomolecular Structure and Dynamics
Mitochondria-endoplasmic reticulum-lipid droplet crosstalk in lipid metabolic reprogramming in type 2 diabetes mellitus
Xinyi Fang, Jiaqi GAO, Yan WANG, Dancing Zhu, Jiaxing Tian, Xiaolin TONG · 2026 · Journal of Lipid Research
Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies
Rongyu Wang, Yingyu Luo, Liying Liu, Jingwen Zhang, Rong Li, Nannan Zhang · 2026 · Antioxidants
Ginsenoside Re Targets Drp1 Leu94 across Species to Restore Mitochondrial Balance through Atg1 ULK1 Mediated Fission and Mitophagy Coupling in Age Related Degeneration
João Silva, Pedro Costa, Ana Beatriz · 2023 · Specialty journal of Pharmacognosy Phytochemistry and Biotechnology