T-Time again – The diversity of actions of thyroid hormones (TH), their aminergic (TAM) and acetic acid (TAc) metabolites
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L-T4 is solely produced by the thyroid gland and serves as a prohormone, while T3 is in part secreted by the thyroid gland and mainly generated in extra-thyroidal tissues by either type 1 or type 2 deiodinase (DIO1, DIO2).
“A century of thyroxine research has led to the commonly held opinion in the thyroid hormone community that 3,3′,5,5′-tetraiodo-L-thyronine (L-Thyroxine, L-T4), which is solely produced by the thyroid gland, serves as a prohormone while T3 (3,3′5-triiodo-L-thyronine), in part secreted by the thyroid gland, is mainly generated in various extra-thyroidal tissues by either type 1 or type 2 deiodinase”
From 3,5-T2—A Janus-Faced Thyroid Hormone Metabolite Exerts Both Canonical T3-Mimetic Endocrine and Intracrine Hepatic Action (2020) · cites this paper as [2]
Cites
The classic pathways of thyroid hormone metabolism
van der Spek, A. H., Fliers, E., & Boelen, A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.025 · Cited by 194 · see citing works
Virili, C., & Centanni, M. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.053 · Cited by 105 · see citing works
Michaelsson, L. F., Medici, B. B., la Cour, J. L., Selmer, C., Røder, M., Perrild, H., Knudsen, N., Faber, J., & Nygaard, B. (2015) · European Thyroid Journal · doi:10.1159/000437262 · Cited by 57 · see citing works
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Köhrle, J., Lehmphul, I., Pietzner, M., Renko, K., Rijntjes, E., Richards, K., Anselmo, J., Danielsen, M., & Jonklaas, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00787 · Cited by 23 · see citing works
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 458
- Pages
- 1-5
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W4249960666
- Cited by
- 3
- References
- 3
- Citations by year
- 2024: 1 · 2020: 1 · 2018: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (HO5096/2-1, KO-922-17-2)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- thyroid hormones, thyroid hormone synthesis, thyroid peroxidase, thyroglobulin, thyroid follicular cells, thyroid-stimulating hormone, hypothyroidism, hyperthyroidism, thyroid cancer, radioiodine therapy, iodine deficiency, goiter, endocrine disruptors, goitrogenic effect, autoimmune thyroiditis, Graves' disease, antithyroid drugs
- MeSH terms
- Amines, Thyroid Hormones, Thyroxine, Triiodothyronine, Acetic Acid, Metabolome
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