Effects of repeated potassium iodide administration on genes involved in synthesis and secretion of thyroid hormone in adult male rat
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Background A single dose of potassium iodide (KI) is recommended to reduce the risk of thyroid cancer during nuclear accidents. However in case of prolonged radioiodine exposure, more than one dose of KI may be necessary. This work aims to evaluate the potential toxic effect of repeated administration of KI. Methods Adult Wistar rats received an optimal dose of KI 1 mg/kg over a period of 1, 4 or 8 days. Results hormonal status (TSH, FT4) of treated rats was unaffected. Contrariwise, a sequential Wolff-Chaikoff effect was observed, resulting in a prompt decrease of NIS and MCT8 mRNA expression (-58% and -26% respectively), followed by a delayed decrease of TPO mRNA expression (-33%) in conjunction with a stimulation of PDS mRNA expression (+62%). Conclusion we show for the first time that repeated administration of KI at 1 mg/kg/24h doesn't cause modification of thyroid hormones level, but leads to a reversible modification of the expression of genes involved in the synthesis and secretion of thyroid hormones.
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Iodide overload decreases MCT8 mRNA and protein expression in rats, thus reducing T4 and T3 secretion into the blood stream.
“Lastly, iodide overload decreased MCT8 mRNA and protein expression in rats, thus reducing T4 and T3 secretion into the blood stream (102, 215).”
From Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion (2022) · cites this paper as [215]
The Discussion (p. 18) reports that MCT8 mRNA decreased one day after KI administration in rats, but attributes the MCT8 protein finding to de Souza et al. (2015), rather than measuring it in this study. The Discussion (p. 19) says thyroid hormone levels were unchanged, so this paper does not establish the claimed reduction of T4 and T3 in the bloodstream. (LLM, conf=0.88)
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The classic pathways of thyroid hormone metabolism
van der Spek, A. H., Fliers, E., & Boelen, A. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.01.025 · Cited by 194 · see citing works
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Groeneweg, S., van Geest, F. S., Peeters, R. P., Heuer, H., & Visser, W. E. (2020) · Endocrine Reviews · doi:10.1210/endrev/bnz008 · Cited by 216 · see citing works
Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
Jing, L., & Zhang, Q. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.992883 · Cited by 61 · see citing works
- Authors
- Lebsir, D., Manens, L., Grison, S., Lestaevel, P., Ebrahimian, T., Suhard, D., Phan, G., Dublineau, I., Tack, K., Benderitter, M., Pech, A., Jourdain, J.-R., & Souidi, M.
- Affiliations
- Institut de Radioprotection et de Sûreté Nucléaire (FR)
- Corresponding author
- Souidi, Maâmar
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 474
- Pages
- 119-126
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2789668511
- Cited by
- 32
- References
- 1
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 3 · 2022: 5 · 2021: 4 · 2020: 6 · 2019: 7 · 2018: 3
- FWCI
- 3.85
- Type
- journal article
- Language
- en
- Open access
- green
- hal.science
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- Funders
- Agence Nationale de la Recherche (ANR-11-RSNR-0019)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Physical Sciences › Environmental Science › Global and Planetary Change › Radioactive contamination and transfer
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Keywords
- potassium iodide, repeated administration, thyroid hormone synthesis, thyroid hormone secretion, thyroid cancer prevention, radioiodine exposure, Wolff-Chaikoff effect, sodium iodide symporter, MCT8, thyroid peroxidase, PDS, thyroxine, thyroid-stimulating hormone, gene expression
- MeSH terms
- Animals, Biological Transport, Gene Expression Regulation, Iodine, Male, Pituitary Gland, Potassium Iodide, RNA, Messenger, Thyroid Gland, Thyroid Hormones, Rats, Wistar
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