The DOI matches its Crossref record; 75 of the 76 references it cites were found in a registry or an index.
Receptor protein tyrosine phosphatase sigma inhibits axon regrowth in the adult injured CNS
Abstract
Recently, receptor protein tyrosine phosphatase-sigma (RPTPsigma) has been shown to inhibit axon regeneration in injured peripheral nerves. Unlike the peripheral nervous system (PNS), central nervous system (CNS) neurons fail to regenerate their axons after injury or in disease. In order to assess the role of RPTPsigma in CNS regeneration, we used the retinocollicular system of adult mice lacking RPTPsigma to evaluate retinal ganglion cell (RGC) axon regrowth after optic nerve lesion. Quantitative analysis demonstrated a significant increase in the number of RGC axons that crossed the glial scar and extended distally in optic nerves from RPTPsigma (-/-) mice compared to wild-type littermate controls. Although we found that RPTPsigma is expressed by adult RGCs in wild-type mice, the retinas and optic nerves of adult RPTPsigma (-/-) mice showed no histological defects. Furthermore, the time-course of RGC death after nerve lesion was not different between knockout and wild-type animals. Thus, enhanced axon regrowth in the absence of RPTPsigma could not be attributed to developmental defects or increased neuronal survival. Finally, we show constitutively elevated activity of mitogen-activated protein kinase (MAPK) and Akt kinase in adult RPTPsigma (-/-) mice retinas, suggesting that these signaling pathways may contribute to promoting RGC axon regrowth following traumatic nerve injury. Our results support a model in which RPTPsigma inhibits axon regeneration in the adult injured CNS.
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“RPTPσ can bind with high affinity to neurocan and aggrecan and strongly inhibits axon outgrowth and regeneration (Sapieha et al., 2005;Shen et al., 2009;Fry et al., 2010;Lang et al., 2015).”
From The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity (2015) · cites this paper as Sapieha et al., 2005
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Cites
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Items 101–108 of 108
MODIFYING CHONDROITIN SULFATION ENHANCES RETINAL GANGLION CELL AXON REGENERATION
Pearson, C. S. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.32374
High temporal frequency light response in mouse retina requires FAT3 signaling in bipolar cellsPreprint
Avilés, E. C., Wang, S. K., Patel, S., Shi, S., Lin, L., Kefalov, V. J., Goodrich, L. V., Cepko, C. L., & Xue, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.02.565326
Chondroitinsulfate proteoglycan receptors in the nervous system
Николаевич, П. М., & Baltina, T. (2014) · Genes and Cells · doi:10.23868/gc120263
Protein Tyrosine Phosphatase Receptor Type S (PTPRS) Regulates Hematopoietic Stem Cell Self-Renewal
Quarmyne, M. (2015) · DukeSpace (Duke University)
La régénération du système nerveux périphérique et central par la voie RSK-RPS6
Decourt, C. (2023) · theses.fr (ABES) · doi:10.70675/03404a46z2d34z458bzb422z41a80f2bdac6
Metadata
- Authors
- Sapieha, P. S., Duplan, L., Uetani, N., Joly, S., Tremblay, M. L., Kennedy, T. E., & Di Polo, A.
- Affiliations
- Université de Montréal (CA)
- McGill University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- Molecular and Cellular Neuroscience
- Publisher
- Elsevier BV
- Published
- 2005-04
- Volume
- 28
- Issue
- 4
- Pages
- 625-635
- ISSN
- 1044-7431 (ISSN-L)
- OpenAlex
- W2092811972
- Cited by
- 106
- References
- 76
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 7 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 15 · 2013: 6 · 2012: 10
- FWCI
- 1.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Molecular and Cellular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- axon regeneration, optic nerve injury, retinal ganglion cells, glial scar, mitogen-activated protein kinase, Akt kinase, knockout mice
- MeSH terms
- Animals, Axons, Female, Mice, Inbred BALB C, Nerve Regeneration, Neural Inhibition, Retinal Ganglion Cells, Protein Tyrosine Phosphatases, Mice, Knockout, Optic Nerve Injuries, Mice, Receptor-Like Protein Tyrosine Phosphatases, Class 2
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