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Cited by 261Alzheimer's disease research and treatmentsMitochondrial Function and PathologyCalcium signaling and nucleotide metabolism

Mitochondria-associated ER membranes in Alzheimer disease

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Schon, Eric A., Area-Gomez, Estela·2013·Molecular and Cellular Neuroscience
DOI 10.1016/j.mcn.2012.07.011
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Abstract

Alzheimer disease (AD) is associated with the accumulation in the brain of extracellular neuritic plaques composed mainly of β-amyloid (Aβ) and of intracellular neurofibrillary tangles composed of hyperphosphorylated forms of the microtubule-associated protein tau. It is also associated with other features that have received less attention, including aberrant phospholipid, cholesterol, and calcium metabolism, and altered mitochondrial function and dynamics. The underlying mechanism(s) that might explain these observations are currently unknown. We recently showed that presenilin-1 (PS1), presenilin-2 (PS2), and γ-secretase activity, which processes the amyloid precursor protein (APP) to generate Aβ, are located predominantly in a specialized subcompartment of the endoplasmic reticulum (ER) that is physically and biochemically connected to mitochondria, called mitochondria-associated ER membranes (MAM). MAM is an intracellular lipid raft-like structure intimately involved in cholesterol and phospholipid lipid metabolism, in calcium homeostasis, and in mitochondrial function and dynamics. The coincidence of the functions associated with MAM with the symptomatology of AD led us to speculate that presenilins play a role in maintaining MAM function. We found that, consistent with this supposition, both MAM function and ER-mitochondrial connectivity are increased significantly in AD, which may help explain many of the biochemical and morphological features of the disease. Based on these findings, we propose that AD is fundamentally a disorder of ER-mitochondrial communication (the "MAM hypothesis"). This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'.

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Authors
Schon, E. A., & Area-Gomez, E.
Affiliations
Columbia University (US)
Venue
Molecular and Cellular Neuroscience
Publisher
Elsevier BV
Published
2013-07
Volume
55
Pages
26-36
ISSN
1044-7431 (ISSN-L)
DOI
10.1016/j.mcn.2012.07.011
OpenAlex
W2029553530
Cited by
261
References
7
Citations by year
2026: 5 · 2025: 14 · 2024: 15 · 2023: 18 · 2022: 11 · 2021: 22 · 2020: 29 · 2019: 19 · 2018: 21 · 2017: 25 · 2016: 28 · 2015: 16 · 2014: 20 · 2013: 15 · 2012: 3
FWCI
1.85
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecular and Cellular Neuroscience (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DIGITAL.CSIC (Spanish National Research Council (CSIC)) (acceptedVersion, other-oa)
Funders
  • U.S. Department of Defense
  • Ellison Medical Foundation
  • American Health Assistance Foundation
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Calcium signaling and nucleotide metabolism
Keywords
Alzheimer's disease, mitochondria-associated ER membranes, presenilin 1, presenilin 2, gamma-secretase, amyloid precursor protein, amyloid-beta, lipid rafts, cholesterol metabolism, phospholipid metabolism, calcium homeostasis, mitochondrial dynamics, neurofibrillary tangles
MeSH terms
Alzheimer Disease, Amyloid, Animals, Endoplasmic Reticulum, Humans, Intracellular Membranes, Mitochondria, Membrane Microdomains, Lipid Metabolism, Presenilins

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