Mechanisms of Neuron Loss in Alzheimer’s Disease

Alzheimer's Disease and Senile Dementia: Loss of Neurons in the Basal Forebrain

Whitehouse, P., Price, D., Struble, R., Clark, A., Coyle, J., & DeLong, M. R. (1982) · Science · doi:10.1126/science.7058341 · Cited by 3,627 · see citing works

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

Nakagawa, T., Zhu, H., Morishima, N., Li, E., Xu, J., Yankner, B. A., & Yuan, J. (2000) · Nature · doi:10.1038/47513 · Cited by 3,262 · see citing works

Pathways towards and Away from Alzheimer’s Disease

Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052 · see citing works

Equal numbers of neuronal and nonneuronal cells make the human brain an isometrically scaled-up primate brain

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Learning enhances adult neurogenesis in the hippocampal formation

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Amyloid Precursor Protein Processing and Alzheimer's Disease

O'Brien, R. J., & Wong, P. C. (2011) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-061010-113613 · Cited by 2,061 · see citing works

Dynamics of hippocampal neurogenesis in adult humans

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Profound Loss of Layer II Entorhinal Cortex Neurons Occurs in Very Mild Alzheimer’s Disease

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Alzheimer disease: Evidence for selective loss of cholinergic neurons in the nucleus basalis

Whitehouse, P. J., Price, D. L., Clark, A. W., Coyle, J. T., & DeLong, M. R. (1981) · Annals of Neurology · doi:10.1002/ana.410100203 · Cited by 1,736 · see citing works

APP Processing and Synaptic Function

Kamenetz, F., Tomita, T., Hsieh, H., Seabrook, G., Borchelt, D., Iwatsubo, T., Sisodia, S., & Malinow, R. (2003) · Neuron · doi:10.1016/s0896-6273(03)00124-7 · Cited by 1,644 · see citing works

beta-Amyloid peptides destabilize calcium homeostasis and render human cortical neurons vulnerable to excitotoxicity

Mattson, M. P., Cheng, B., Davis, D. G., Bryant, K., Lieberburg, I. M., & Rydel, R. E. (1992) · Journal of Neuroscience · doi:10.1523/jneurosci.12-02-00376.1992 · Cited by 1,627 · see citing works

Life and Death of Neurons in the Aging Brain

Morrison, J. H., & Hof, P. R. (1997) · Science · doi:10.1126/science.278.5337.412 · Cited by 1,344 · see citing works

Synaptic Activity Regulates Interstitial Fluid Amyloid-β Levels In Vivo

Cirrito, J. R., Yamada, K. A., Finn, M. B., Sloviter, R. S., Bales, K. R., May, P. C., Schoepp, D. D., Paul, S. M., Mennerick, S., & Holtzman, D. M. (2005) · Neuron · doi:10.1016/j.neuron.2005.10.028 · Cited by 1,265 · see citing works

Unbiased stereological estimation of the number of neurons in the human hippocampus

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Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

Giannakopoulos, P., Herrmann, F. R., Bussière, T., Bouras, C., Kövari, E., Perl, D. P., Morrison, J. H., Gold, G., & Hof, P. R. (2003) · Neurology · doi:10.1212/01.wnl.0000063311.58879.01 · Cited by 1,118 · see citing works

Mitochondria are a direct site of Aβ accumulation in Alzheimer's disease neurons: implications for free radical generation and oxidative damage in disease progression

Manczak, M., Anekonda, T. S., Henson, E., Park, B. S., Quinn, J., & Reddy, P. H. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl066 · Cited by 1,104 · see citing works

Structural Brain Changes in Aging: Courses, Causes and Cognitive Consequences

Fjell, A. M., & Walhovd, K. B. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.3.187 · Cited by 1,085 · see citing works

Neuronal Loss Is Greater in the Locus Coeruleus Than Nucleus Basalis and Substantia Nigra in Alzheimer and Parkinson Diseases

Zarow, C., Lyness, S. A., Mortimer, J. A., & Chui, H. C. (2003) · Archives of Neurology · doi:10.1001/archneur.60.3.337 · Cited by 1,003 · see citing works

Intraneuronal Aβ42 Accumulation in Human Brain

Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., et al. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64700-1 · Cited by 991 · see citing works

Amyloid ion channels: A common structural link for protein-misfolding disease

Quist, A. P., Doudevski, I., Lin, H., Azimova, R., Ng, D., Frangione, B., Kagan, B. L., Ghiso, J. A., & Lal, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502066102 · Cited by 982 · see citing works

Increased hippocampal neurogenesis in Alzheimer's disease

Jin, K., Peel, A. L., Mao, X. O., Xie, L., Cottrell, B. A., Henshall, D. C., & Greenberg, D. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2634794100 · Cited by 971 · see citing works

Mitochondria take center stage in aging and neurodegeneration

Beal, M. F. (2005) · Annals of Neurology · doi:10.1002/ana.20624 · Cited by 957 · see citing works

Neurogenesis in the striatum of the adult human brain

Ernst, A., Alkass, K., Bernard, S., Salehpour, M., Perl, S., Tisdale, J., Possnert, G., Druid, H., & Frisén, J. (2014) · Cell · doi:10.1016/j.cell.2014.01.044 · Cited by 937 · see citing works

GSK-3β Regulates Phosphorylation of CRMP-2 and Neuronal Polarity

Yoshimura, T., Kawano, Y., Arimura, N., Kawabata, S., Kikuchi, A., & Kaibuchi, K. (2005) · Cell · doi:10.1016/j.cell.2004.11.012 · Cited by 877 · see citing works

Neurogenesis may relate to some but not all types of hippocampal‐dependent learning

Shors, T. J., Townsend, D. A., Zhao, M., Kozorovitskiy, Y., & Gould, E. (2002) · Hippocampus · doi:10.1002/hipo.10103 · Cited by 853 · see citing works

Corridors of migrating neurons in the human brain and their decline during infancy

Sanai, N., Nguyen, T., Ihrie, R. A., Mirzadeh, Z., Tsai, H.-H., Wong, M., Gupta, N., Berger, M. S., Huang, E., Garcia-Verdugo, J.-M., et al. (2011) · Nature · doi:10.1038/nature10487 · Cited by 849 · see citing works

GSK3 signalling in neural development

Hur, E., & Zhou, F. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2870 · Cited by 828 · see citing works

Loss of neurons in the nucleus basalis of Meynert in Alzheimer's disease, paralysis agitans and Korsakoff's disease

Arendt, T., Bigl, V., Arendt, A., & Tennstedt, A. (1983) · Acta Neuropathologica · doi:10.1007/bf00697388 · Cited by 817 · see citing works

The secretases: enzymes with therapeutic potential in Alzheimer disease

De Strooper, B., Vassar, R., & Golde, T. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2009.218 · Cited by 799 · see citing works

Neuron numbers and dendritic extent in normal aging and Alzheimer’s disease

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CRMP-2 binds to tubulin heterodimers to promote microtubule assembly

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Mitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease

Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works

Evidence that amyloid beta-peptide-induced lipid peroxidation and its sequelae in Alzheimer’s disease brain contribute to neuronal death1

Allanbutterfield, D., Castegna, A., Lauderback, C. M., & Drake, J. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00340-2 · Cited by 715 · see citing works

Loss of neurons of origin of the adrenergic projection to cerebral cortex (nucleus locus ceruleus) in senile dementia

Bondareff, W., Mountjoy, C. Q., & Roth, M. (1982) · Neurology · doi:10.1212/wnl.32.2.164 · Cited by 693 · see citing works

Neocortical cell counts in normal human adult aging

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Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years

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Potential role for adult neurogenesis in the encoding of time in new memories

Aimone, J. B., Wiles, J., & Gage, F. H. (2006) · Nature Neuroscience · doi:10.1038/nn1707 · Cited by 644 · see citing works

Neuronal loss, neurofibrillary tangles and granulovacuolar degeneration in the hippocampus with ageing and dementia: A quantitative study

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Cell death in the nervous system

Bredesen, D. E., Rao, R. V., & Mehlen, P. (2006) · Nature · doi:10.1038/nature05293 · Cited by 638 · see citing works

Autophagy failure in Alzheimer's disease—locating the primary defect

Nixon, R. A., & Yang, D. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.01.021 · Cited by 634 · see citing works

Tau phosphorylation in neuronal cell function and dysfunction

Johnson, G. V. W., & Stoothoff, W. H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01558 · Cited by 624 · see citing works

Neocortical glial cell numbers in human brains

Pelvig, D. P., Pakkenberg, H., Stark, A. K., & Pakkenberg, B. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.04.013 · Cited by 601 · see citing works

Neuron Number in the Entorhinal Cortex and CA1 in Preclinical Alzheimer Disease

Price, J. L., Ko, A. I., Wade, M. J., Tsou, S. K., McKeel, D. W., & Morris, J. C. (2001) · Archives of Neurology · doi:10.1001/archneur.58.9.1395 · Cited by 596 · see citing works

The Control of Neuron Number

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The unfolded protein response is activated in Alzheimer’s disease

Hoozemans, J. J. M., Veerhuis, R., van Haastert, E. S., Rozemüller, A. J. M., Baas, F., Eikelenboom, P., & Scheper, W. (2005) · Acta Neuropathologica · doi:10.1007/s00401-005-1038-0 · Cited by 549 · see citing works

Serotonin in Aging, Late-Life Depression, and Alzheimer's Disease: The Emerging Role of Functional Imaging

MELTZER, C. C. (1998) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00194-2 · Cited by 517 · see citing works

Both the Establishment and the Maintenance of Neuronal Polarity Require Active Mechanisms

Jiang, H., Guo, W., Liang, X., & Rao, Y. (2005) · Cell · doi:10.1016/j.cell.2004.12.033 · Cited by 494 · see citing works

Adult-Born Hippocampal Dentate Granule Cells Undergoing Maturation Modulate Learning and Memory in the Brain

Deng, W., Saxe, M. D., Gallina, I. S., & Gage, F. H. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3362-09.2009 · Cited by 493 · see citing works

Evidence for Apoptotic Cell Death in Alzheimer's Disease

Smale, G., Nichols, N. R., Brady, D. R., Finch, C. E., & Horton, W. E. (1995) · Experimental Neurology · doi:10.1006/exnr.1995.1025 · Cited by 488 · see citing works

Aging and the human neocortex

Pakkenberg, B. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00151-1 · Cited by 485 · see citing works

Disruption of neurogenesis by amyloid β‐peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

Haughey, N. J., Nath, A., Chan, S. L., Borchard, A. C., Rao, M. S., & Mattson, M. P. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01267.x · Cited by 466 · see citing works

β-Amyloid Activates the Mitogen-Activated Protein Kinase Cascade via Hippocampal α7 Nicotinic Acetylcholine Receptors:<i>In Vitro</i>and<i>In Vivo</i>Mechanisms Related to Alzheimer's Disease

Dineley, K. T., Westerman, M., Bui, D., Bell, K., Ashe, K. H., & Sweatt, J. D. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-12-04125.2001 · Cited by 462 · see citing works

Distribution of Active Glycogen Synthase Kinase 3β (GSK-3β) in Brains Staged for Alzheimer Disease Neurofibrillary Changes

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Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3β phosphorylation

Zumbrunn, J., Kinoshita, K., Hyman, A. A., & Näthke, I. S. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00002-1 · Cited by 438 · see citing works

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

Magnusson, J. P., Göritz, C., Tatarishvili, J., Dias, D. O., Smith, E. M. K., Lindvall, O., Kokaia, Z., & Frisén, J. (2014) · Science · doi:10.1126/science.346.6206.237 · Cited by 433 · see citing works

Increased level of active GSK‐3β in Alzheimer’s disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration

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The Age of Olfactory Bulb Neurons in Humans

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Amyloid beta from axons and dendrites reduces local spine number and plasticity

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Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid

Troy, C. M., Rabacchi, S. A., Friedman, W., Frappier, T. F., Brown, K. R., & Shelanski, M. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-04-01386.2000 · Cited by 354 · see citing works

Increased proliferation reflects glial and vascular-associated changes, but not neurogenesis in the presenile Alzheimer hippocampus.

Boekhoorn, K., Joëls, M., & Lucassen, P. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.04.017 · Cited by 342 · see citing works

Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

Sevrioukova, I. F. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3445 · Cited by 338 · see citing works

Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

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The dysregulation of intracellular calcium in Alzheimer disease

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Mitochondrial Dysfunctions in Neurodegenerative Diseases: Relevance to Alzheimer’s Disease

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A functional hypothesis for adult hippocampal neurogenesis: Avoidance of catastrophic interference in the dentate gyrus

Wiskott, L., Rasch, M. J., & Kempermann, G. (2006) · Hippocampus · doi:10.1002/hipo.20167 · Cited by 292 · see citing works

A quantitative study of the human cerebellum with unbiased stereological techniques

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β‐Amyloid neurotoxicity is mediated by a glutamate‐triggered excitotoxic cascade in rat nucleus basalis

Harkany, T., Ábrahám, I. M., Timmerman, W., Laskay, G., Tóth, B., Sasvári, M., Kónya, C., Sebens, J. B., Korf, J., Nyakas, C. J., et al. (2000) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2000.00164.x · Cited by 275 · see citing works

A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP

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GSK-3 Phosphorylation of the Alzheimer Epitope within Collapsin Response Mediator Proteins Regulates Axon Elongation in Primary Neurons

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Allopregnanolone reverses neurogenic and cognitive deficits in mouse model of Alzheimer's disease

Wang, J. M., Singh, C., Liu, L., Irwin, R. W., Chen, S., Chung, E. J., Thompson, R. F., & Brinton, R. D. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001422107 · Cited by 263 · see citing works

Mitochondria-associated ER membranes in Alzheimer disease

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The Neurosteroid Allopregnanolone Promotes Proliferation of Rodent and Human Neural Progenitor Cells and Regulates Cell-Cycle Gene and Protein Expression

Wang, J. M., Johnston, P. B., Ball, B. G., & Brinton, R. D. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4520-04.2005 · Cited by 261 · see citing works

APC and GSK-3β Are Involved in mPar3 Targeting to the Nascent Axon and Establishment of Neuronal Polarity

Shi, S., Cheng, T., Jan, L. Y., & Jan, Y. N. (2004) · Current Biology · doi:10.1016/j.cub.2004.11.009 · Cited by 259 · see citing works

Decreased neurogenesis after cholinergic forebrain lesion in the adult rat

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Amyloid-β as a Modulator of Synaptic Plasticity

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GSK-3: A Bifunctional Role in Cell Death Pathways

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Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

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The amyloid precursor protein intracellular domain (AICD) as modulator of gene expression, apoptosis, and cytoskeletal dynamics—Relevance for Alzheimer's disease

Müller, T., Meyer, H. E., Egensperger, R., & Marcus, K. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.05.002 · Cited by 242 · see citing works

Failure of Neuronal Maturation in Alzheimer Disease Dentate Gyrus

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Age, Alzheimer disease, and brain structure

Raji, C. A., López, O. L., Kuller, L. H., Carmichael, O. T., & Becker, J. T. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c3f293 · Cited by 230 · see citing works

New Nerve Cells for the Adult Brain

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Caspase-3 activation as a bifurcation point between plasticity and cell death

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Aβ-Mediated NMDA Receptor Endocytosis in Alzheimer's Disease Involves Ubiquitination of the Tyrosine Phosphatase STEP 61

Kurup, P. K., Zhang, Y., Xu, J., Venkitaramani, D. V., Haroutunian, V. H., Greengard, P., Nairn, A. C., & Lombroso, P. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0157-10.2010 · Cited by 222 · see citing works

G Protein-Mediated Neuronal DNA Fragmentation Induced by Familial Alzheimer's Disease-Associated Mutants of APP

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Programmed Cell Death of Adult-Generated Hippocampal Neurons Is Mediated by the Proapoptotic Gene Bax

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Biomarkers of lipid peroxidation in Alzheimer disease (AD): an update

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Mature neurons: equipped for survival

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Functional Consequences of Locus Coeruleus Degeneration in Alzheimers Disease

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Altered neurogenesis in Alzheimer's disease

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?-amyloid Ca2+-channel hypothesis for neuronal death in Alzheimer Disease

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In vivo cellular and molecular mechanisms of neuronal apoptosis in the mammalian CNS

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Neurogenesis in Alzheimer’s disease

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