Cited by 147AI in cancer detectionCell Image Analysis TechniquesMedical Image Segmentation Techniques

NuClick: A deep learning framework for interactive segmentation of microscopic images

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Alemi Koohbanani, Navid, Jahanifar, Mostafa, Zamani Tajadin, Neda, Rajpoot, Nasir·2020·Medical Image Analysis

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  • The human-in-the-loop approach has been demonstrated for simple ROI such as nuclei and round cells, but not for cells with complex morphologies that require full cytoplasmic segmentation.

    “This approach has been demonstrated for simple ROI such as nuclei and round cells, which allow for weak annotations such as clicks and squiggles18,19, but not for cells with complex morphologies that require full cytoplasmic segmentation.”

    From Cellpose 2.0: how to train your own model (2022) · cites this paper as [18]

    The Abstract and §2.3 describe interactive segmentation of nuclei and cells using clicks and glands using squiggles. The paper does not establish the claimed limitation for cells with complex morphologies requiring full cytoplasmic segmentation; it also reports segmentation of whole white blood cells (§4.5). (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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Research works printed but not linked: 62

  1. O. Russakovsky, J. Deng, H. Su, J. Krause, S. Satheesh, S. Ma, Z. Huang, A. Karpathy, A. Khosla, M. Bernstein, et al., Imagenet large scale visual recognition challenge, International journal of computer vision 115 (2015) 211-252.
  2. S. A. Taghanaki, K. Abhishek, J. P. Cohen, J. Cohen-Adad, G. Hamarneh, Deep semantic segmentation of natural and medical images: A review, accepted to appear in Springer Artificial Intelligence Review (2020).
  3. N. Kumar, R. Verma, D. Anand, Y. Zhou, O. F. Onder, E. Tsougenis, H. Chen, P. A. Heng, J. Li, Z. Hu, et al., A multi-organ nucleus segmentation chal- lenge, IEEE transactions on medical imaging (2019).
  4. N. A. Koohbanani, M. Jahanifar, A. Gooya, N. Rajpoot, Nuclear instance seg- mentation using a proposal-free spatially aware deep learning framework, in: International Conference on Medical Image Computing and Computer- Assisted Intervention, Springer, 2019, pp. 622-630.
  5. H. Pinckaers, G. Litjens, Neural ordinary differential equations for semantic segmentation of individual colon glands, arXiv preprint arXiv:1910.10470 (2019). · arXiv
  6. H. Chen, X. Qi, L. Yu, P.-A. Heng, Dcan: deep contour-aware networks for accurate gland segmentation, in: Proceedings of the IEEE conference on Computer Vision and Pattern Recognition, 2016, pp. 2487-2496.
  7. J. Gamper, N. A. Koohbanani, S. Graham, M. Jahanifar, S. A. Khurram, A. Azam, K. Hewitt, N. Rajpoot, Pannuke dataset extension, insights and baselines, arXiv preprint arXiv:2003.10778 (2020). · arXiv
  8. Y. Zhou, O. F. Onder, Q. Dou, E. Tsougenis, H. Chen, P.-A. Heng, Cia-net: Robust nuclei instance segmentation with contour-aware information aggre- gation, in: International Conference on Information Processing in Medical Imaging, Springer, 2019, pp. 682-693.
  9. I. Yoo, D. Yoo, K. Paeng, Pseudoedgenet: Nuclei segmentation only with point annotations, in: International Conference on Medical Image Computing and Computer-Assisted Intervention, Springer, 2019, pp. 731-739.
  10. H. Qu, P. Wu, Q. Huang, J. Yi, G. M. Riedlinger, S. De, D. N. Metaxas, Weakly supervised deep nuclei segmentation using points annotation in histopathol- ogy images, in: International Conference on Medical Imaging with Deep Learning, 2019, pp. 390-400.
  11. D. Pathak, E. Shelhamer, J. Long, T. Darrell, Fully convolutional multi-class multiple instance learning, arXiv preprint arXiv:1412.7144 (2014). · arXiv
  12. A. Kolesnikov, C. H. Lampert, Seed, expand and constrain: Three principles for weakly-supervised image segmentation, in: European Conference on Computer Vision, Springer, 2016, pp. 695-711.
  13. D. Pathak, P. Krahenbuhl, T. Darrell, Constrained convolutional neural net- works for weakly supervised segmentation, in: Proceedings of the IEEE international conference on computer vision, 2015, pp. 1796-1804.
  14. Y. Wei, H. Xiao, H. Shi, Z. Jie, J. Feng, T. S. Huang, Revisiting dilated con- volution: A simple approach for weakly-and semi-supervised semantic seg- mentation, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2018, pp. 7268-7277.
  15. A. Khoreva, R. Benenson, J. Hosang, M. Hein, B. Schiele, Simple does it: Weakly supervised instance and semantic segmentation, in: Proceedings of the IEEE conference on computer vision and pattern recognition, 2017, pp. 876-885.
  16. B. Jin, M. V. Ortiz Segovia, S. Susstrunk, Webly supervised semantic segmen- tation, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2017, pp. 3626-3635.
  17. E. Ahmed, S. Cohen, B. Price, Semantic object selection, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2014, pp. 3150-3157.
  18. A. Bearman, O. Russakovsky, V. Ferrari, L. Fei-Fei, What's the point: Semantic segmentation with point supervision, in: European conference on computer vision, Springer, 2016, pp. 549-565.
  19. S. Bell, P. Upchurch, N. Snavely, K. Bala, Material recognition in the wild with the materials in context database, in: Proceedings of the IEEE conference on computer vision and pattern recognition, 2015, pp. 3479-3487.
  20. D.-J. Chen, J.-T. Chien, H.-T. Chen, L.-W. Chang, Tap and shoot segmentation, in: Thirty-Second AAAI Conference on Artificial Intelligence, 2018.
  21. D. Lin, J. Dai, J. Jia, K. He, J. Sun, Scribblesup: Scribble-supervised convo- lutional networks for semantic segmentation, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2016, pp. 3159- 3167.
  22. J. Xu, A. G. Schwing, R. Urtasun, Learning to segment under various forms of weak supervision, in: Proceedings of the IEEE conference on computer vision and pattern recognition, 2015, pp. 3781-3790.
  23. X. Bai, G. Sapiro, Geodesic matting: A framework for fast interactive im- age and video segmentation and matting, International journal of computer vision 82 (2009) 113-132.
  24. D. Batra, A. Kowdle, D. Parikh, J. Luo, T. Chen, Interactively co-segmentating topically related images with intelligent scribble guidance, International journal of computer vision 93 (2011) 273-292.
  25. Y. Y. Boykov, M.-P. Jolly, Interactive graph cuts for optimal boundary & region segmentation of objects in nd images, in: Proceedings eighth IEEE interna- tional conference on computer vision. ICCV 2001, volume 1, IEEE, 2001, pp. 105-112.
  26. C. Rother, V. Kolmogorov, A. Blake, Grabcut: Interactive foreground extrac- tion using iterated graph cuts, in: ACM transactions on graphics (TOG), volume 23, ACM, 2004, pp. 309-314.
  27. M.-M. Cheng, V. A. Prisacariu, S. Zheng, P. H. Torr, C. Rother, Densecut: Densely connected crfs for realtime grabcut, in: Computer Graphics Forum, volume 34, Wiley Online Library, 2015, pp. 193-201.
  28. V. Gulshan, C. Rother, A. Criminisi, A. Blake, A. Zisserman, Geodesic star convexity for interactive image segmentation, in: 2010 IEEE Computer So- ciety Conference on Computer Vision and Pattern Recognition, IEEE, 2010, pp. 3129-3136.
  29. N. Shankar Nagaraja, F. R. Schmidt, T. Brox, Video segmentation with just a few strokes, in: Proceedings of the IEEE International Conference on Computer Vision, 2015, pp. 3235-3243.
  30. Z. Li, Q. Chen, V. Koltun, Interactive image segmentation with latent diversity, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2018, pp. 577-585.
  31. D. P. Papadopoulos, J. R. Uijlings, F. Keller, V. Ferrari, Extreme clicking for efficient object annotation, in: Proceedings of the IEEE International Con- ference on Computer Vision, 2017, pp. 4930-4939.
  32. V. Kwatra, A. Schödl, I. Essa, G. Turk, A. Bobick, Graphcut textures: image and video synthesis using graph cuts, in: ACM Transactions on Graphics (ToG), volume 22, ACM, 2003, pp. 277-286.
  33. N. Xu, B. Price, S. Cohen, J. Yang, T. Huang, Deep grabcut for object selection, arXiv preprint arXiv:1707.00243 (2017). · arXiv
  34. N. Xu, B. Price, S. Cohen, J. Yang, T. S. Huang, Deep interactive object se- lection, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2016, pp. 373-381.
  35. E. Agustsson, J. R. Uijlings, V. Ferrari, Interactive full image segmentation by considering all regions jointly, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2019, pp. 11622-11631.
  36. K.-K. Maninis, S. Caelles, J. Pont-Tuset, L. Van Gool, Deep extreme cut: From extreme points to object segmentation, in: Proceedings of the IEEE Confer- ence on Computer Vision and Pattern Recognition, 2018, pp. 616-625.
  37. H. Ling, J. Gao, A. Kar, W. Chen, S. Fidler, Fast interactive object annota- tion with curve-gcn, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2019, pp. 5257-5266.
  38. L. Castrejon, K. Kundu, R. Urtasun, S. Fidler, Annotating object instances with a polygon-rnn, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2017, pp. 5230-5238.
  39. D. Acuna, H. Ling, A. Kar, S. Fidler, Efficient interactive annotation of seg- mentation datasets with polygon-rnn++, in: Proceedings of the IEEE Con- ference on Computer Vision and Pattern Recognition, 2018, pp. 859-868.
  40. Z. Wang, D. Acuna, H. Ling, A. Kar, S. Fidler, Object instance annotation with deep extreme level set evolution, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2019, pp. 7500-7508.
  41. V. Caselles, R. Kimmel, G. Sapiro, Geodesic active contours, International journal of computer vision 22 (1997) 61-79.
  42. D. Acuna, A. Kar, S. Fidler, Devil is in the edges: Learning semantic bound- aries from noisy annotations, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2019, pp. 11075-11083.
  43. T. Sakinis, F. Milletari, H. Roth, P. Korfiatis, P. Kostandy, K. Philbrick, Z. Akkus, Z. Xu, D. Xu, B. J. Erickson, Interactive segmentation of med- ical images through fully convolutional neural networks, arXiv preprint arXiv:1903.08205 (2019). · arXiv
  44. M. Andriluka, J. R. Uijlings, V. Ferrari, Fluid annotation: a human-machine collaboration interface for full image annotation, in: Proceedings of the 26th ACM international conference on Multimedia, 2018, pp. 1957-1966.
  45. K. He, G. Gkioxari, P. Dollár, R. Girshick, Mask r-cnn, in: Proceedings of the IEEE international conference on computer vision, 2017, pp. 2961-2969.
  46. C. Nieuwenhuis, D. Cremers, Spatially varying color distributions for inter- active multilabel segmentation, IEEE transactions on pattern analysis and machine intelligence 35 (2012) 1234-1247.
  47. C. Nieuwenhuis, S. Hawe, M. Kleinsteuber, D. Cremers, Co-sparse textural similarity for interactive segmentation, in: European conference on com- puter vision, Springer, 2014, pp. 285-301.
  48. J. Santner, T. Pock, H. Bischof, Interactive multi-label segmentation, in: Asian Conference on Computer Vision, Springer, 2010, pp. 397-410.
  49. V. Vezhnevets, V. Konouchine, Growcut: Interactive multi-label nd image seg- mentation by cellular automata, in: proc. of Graphicon, volume 1, Citeseer, 2005, pp. 150-156.
  50. M. Jahanifar, N. A. Koohbanani, N. Rajpoot, Nuclick: From clicks in the nuclei to nuclear boundaries, arXiv preprint arXiv:1909.03253 (2019). · arXiv
  51. J. Wu, Y. Zhao, J.-Y. Zhu, S. Luo, Z. Tu, Milcut: A sweeping line multiple instance learning paradigm for interactive image segmentation, in: Proceed- ings of the IEEE Conference on Computer Vision and Pattern Recognition, 2014, pp. 256-263.
  52. C. Rother, V. Kolmogorov, A. Blake, Interactive foreground extraction using iterated graph cuts, ACM Transactions on Graphics 23 (2012)
  53. M. H. Hesamian, W. Jia, X. He, P. Kennedy, Deep learning techniques for med- ical image segmentation: Achievements and challenges, Journal of digital imaging 32 (2019) 582-596.
  54. A. Garcia-Garcia, S. Orts-Escolano, S. Oprea, V. Villena-Martinez, J. Garcia- Rodriguez, A review on deep learning techniques applied to semantic seg- mentation, arXiv preprint arXiv:1704.06857 (2017). · arXiv
  55. M. Jahanifar, N. Z. Tajeddin, N. A. Koohbanani, A. Gooya, N. Rajpoot, Seg- mentation of skin lesions and their attributes using multi-scale convolu- tional neural networks and domain specific augmentations, arXiv preprint arXiv:1809.10243 (2018). · arXiv
  56. L.-C. Chen, G. Papandreou, F. Schroff, H. Adam, Rethinking atrous convo- lution for semantic image segmentation, arXiv preprint arXiv:1706.05587 (2017). · arXiv
  57. J. Serra, Image analysis and mathematical morphology, Academic Press, Inc., 1983.
  58. N. Kumar, R. Verma, S. Sharma, S. Bhargava, A. Vahadane, A. Sethi, A dataset and a technique for generalized nuclear segmentation for compu- tational pathology, IEEE transactions on medical imaging 36 (2017) 1550- 1560.
  59. A. Kirillov, K. He, R. Girshick, C. Rother, P. Dollár, Panoptic segmentation, in: Proceedings of the IEEE conference on computer vision and pattern recog- nition, 2019, pp. 9404-9413.
  60. J. Long, E. Shelhamer, T. Darrell, Fully convolutional networks for semantic segmentation, in: Proceedings of the IEEE conference on computer vision and pattern recognition, 2015, pp. 3431-3440.
  61. R. Adams, L. Bischof, Seeded region growing, IEEE Transactions on pattern analysis and machine intelligence 16 (1994) 641-647.
  62. T. F. Chan, L. A. Vese, Active contours without edges, IEEE Transactions on image processing 10 (2001) 266-277.

Cited by

Sorted by citations

Authors
Alemi Koohbanani, N., Jahanifar, M., Zamani Tajadin, N., & Rajpoot, N.
Affiliations
University of Warwick (GB)
Venue
Medical Image Analysis
Publisher
Elsevier BV
Published
2020-10
Volume
65
Pages
101771
ISSN
1361-8415 (ISSN-L)
OpenAlex
W3040784645
Cited by
147
References
5
Citations by year
2026: 8 · 2025: 24 · 2024: 34 · 2023: 29 · 2022: 29 · 2021: 22 · 2020: 1
FWCI
7.96
Type
journal article
Language
en
Open access
Locations
  • Medical Image Analysis (publishedVersion)
  • PubMed (publishedVersion)
  • Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
Funders
  • Medical Research Council
  • Innovate UK
  • Alan Turing Institute
Topics
  • Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
Keywords
interactive segmentation, nuclei segmentation, cell segmentation, gland segmentation, histological images, computational pathology, instance segmentation, blood smear images
MeSH terms
Deep Learning, Histological Techniques, Humans, Image Processing, Computer-Assisted

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