NuClick: A deep learning framework for interactive segmentation of microscopic images
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The human-in-the-loop approach has been demonstrated for simple ROI such as nuclei and round cells, but not for cells with complex morphologies that require full cytoplasmic segmentation.
“This approach has been demonstrated for simple ROI such as nuclei and round cells, which allow for weak annotations such as clicks and squiggles18,19, but not for cells with complex morphologies that require full cytoplasmic segmentation.”
From Cellpose 2.0: how to train your own model (2022) · cites this paper as [18]
The Abstract and §2.3 describe interactive segmentation of nuclei and cells using clicks and glands using squiggles. The paper does not establish the claimed limitation for cells with complex morphologies requiring full cytoplasmic segmentation; it also reports segmentation of whole white blood cells (§4.5). (LLM, conf=0.87)
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“For example, [23] encodes users’ clicks and scribbles as binary maps (in case of clicks) or as binarized distance transform maps (for scribbles), which are used as additional input channels of the image to segment.”
BackgroundMethodTian, Z., He, Y., Sun, L., Li, Y., & Du, S. (2024) · Neurocomputing · doi:10.1016/j.neucom.2024.128184 · Cited by 5 · see citing works
- Authors
- Alemi Koohbanani, N., Jahanifar, M., Zamani Tajadin, N., & Rajpoot, N.
- Affiliations
- University of Warwick (GB)
- Venue
- Medical Image Analysis
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 65
- Pages
- 101771
- ISSN
- 1361-8415 (ISSN-L)
- OpenAlex
- W3040784645
- Cited by
- 147
- References
- 5
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 34 · 2023: 29 · 2022: 29 · 2021: 22 · 2020: 1
- FWCI
- 7.96
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Medical Image Analysis (publishedVersion)
- PubMed (publishedVersion)
- Warwick Research Archive Portal (University of Warwick) (acceptedVersion)
- Funders
- Medical Research Council
- Innovate UK
- Alan Turing Institute
- Topics
- Physical Sciences › Computer Science › Artificial Intelligence › AI in cancer detection
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Cell Image Analysis Techniques
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- interactive segmentation, nuclei segmentation, cell segmentation, gland segmentation, histological images, computational pathology, instance segmentation, blood smear images
- MeSH terms
- Deep Learning, Histological Techniques, Humans, Image Processing, Computer-Assisted
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