A microfluidic gradient generator to simulate the oxygen microenvironment in cancer cell culture
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Through precise microfluidic designs, microfluidic devices can reconstruct physiological dynamic characteristics in tissues, such as physiological flow, shear stress, nutrient delivery, and drug action, in a controllable environment.
“Through precise microfluidic designs, microfluidic devices can reconstruct physiological dynamic characteristics in tissues, such as physiological flow, shear stress, nutrient delivery, and drug action, in a controllable environment, providing a platform for cell culture, microenvironment creation, and organ simulation or in vitro assessment of organ tissue60–67.”
From Tumor-on-a-chip: from bioinspired design to biomedical application (2021) · cites this paper as [60]
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- Authors
- Orcheston-Findlay, L., Hashemi, A., Garrill, A., & Nock, V.
- Affiliations
- University of Canterbury (NZ)
- Corresponding author
- Orcheston-Findlay, Louise
- Venue
- Microelectronic Engineering
- Publisher
- Elsevier BV
- Published
- 2018-08
- Volume
- 195
- Pages
- 107-113
- ISSN
- 0167-9317 (ISSN-L)
- OpenAlex
- W2795730083
- Cited by
- 32
- References
- 21
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 3
- FWCI
- 1.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Microelectronic Engineering (publishedVersion)
- UC Research Repository (University of Canterbury) (submittedVersion)
- Funders
- Biomolecular Interaction Centre
- MacDiarmid Institute for Advanced Materials and Nanotechnology
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- dissolved oxygen gradient, hypoxia, tumor microenvironment, 2D cell culture, Ishikawa cells, anticancer drug screening
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