Cited by 32Microfluidic and Capillary Electrophoresis ApplicationsMicrofluidic and Bio-sensing Technologies3D Printing in Biomedical Research

A microfluidic gradient generator to simulate the oxygen microenvironment in cancer cell culture

Orcheston-Findlay, Louise, Hashemi, Azadeh, Garrill, Ashley, Nock, Volker·2018·Microelectronic Engineering

Integrity signals

Registry

Crossref · 10.1016/j.mee.2018.04.011

Cites

21 of 21 references verified0 citation errors · 0 not checkable

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  • Through precise microfluidic designs, microfluidic devices can reconstruct physiological dynamic characteristics in tissues, such as physiological flow, shear stress, nutrient delivery, and drug action, in a controllable environment.

    “Through precise microfluidic designs, microfluidic devices can reconstruct physiological dynamic characteristics in tissues, such as physiological flow, shear stress, nutrient delivery, and drug action, in a controllable environment, providing a platform for cell culture, microenvironment creation, and organ simulation or in vitro assessment of organ tissue60–67.”

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Authors
Orcheston-Findlay, L., Hashemi, A., Garrill, A., & Nock, V.
Affiliations
University of Canterbury (NZ)
Corresponding author
Orcheston-Findlay, Louise
Venue
Microelectronic Engineering
Publisher
Elsevier BV
Published
2018-08
Volume
195
Pages
107-113
ISSN
0167-9317 (ISSN-L)
OpenAlex
W2795730083
Cited by
32
References
21
Citations by year
2026: 4 · 2025: 1 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 5 · 2020: 2 · 2019: 3
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Locations
  • Microelectronic Engineering (publishedVersion)
  • UC Research Repository (University of Canterbury) (submittedVersion)
Funders
  • Biomolecular Interaction Centre
  • MacDiarmid Institute for Advanced Materials and Nanotechnology
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
  • Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Bio-sensing Technologies
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords
dissolved oxygen gradient, hypoxia, tumor microenvironment, 2D cell culture, Ishikawa cells, anticancer drug screening

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