Vibrio cholerae O1 lineages driving cholera outbreaks during seventh cholera pandemic in Ghana
Open accessAbstract
In recent years, the frequency of cholera epidemics across Africa has increased significantly with thousands of people dying each year. However, there still exists a lack of information concerning the Vibrio cholerae O1 lineages driving early and contemporary epidemics since the seventh cholera pandemic started in the continent. This compromises the understanding of the forces determining the epidemiology of cholera in Africa and its control. This study aimed to analyze a collection of V. cholerae O1 strains from the beginning of the seventh cholera pandemic in Ghana and to compare them with recent isolates to understand the evolution of the cholera epidemic in Ghana. V. cholerae O1 strains were characterized by means of Multilocus Sequence Analysis (MLSA), genes from the virulence core genome (VCG), and genes related to the choleragenic phenotype. Our results revealed two major clusters of Ghanaian V. cholerae O1 strains, El Tor and Amazonia/Ghana. Concerning the virulence genes, all strains harbored the set of VCG and most were positive for VSP-II genomic island. The ctxB gene of the contemporary strains was characterized as Altered El Tor. The strains from 1970 to 1980 were susceptible to all antibiotics tested, except for the Amazonia/Ghana cluster that was resistant to aminoglycosides and carried the class 2 integron with the sat2-aadA1 arrangement. This study showed that distinct V. cholerae O1 were the determinants of cholera outbreaks in Ghana. Thus, in endemic region…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the past decade, Vibrio cholerae isolates have become resistant to penicillins, aminoglycosides and sulfonamides, quinolones, tetracycline, macrolides, and phenicols.
“In the past decade, V. cholerae isolates have become resistant to penicillins, aminoglycosides and sulfonamides, quinolones, tetracycline, macrolides, and phenicols”
From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [56]
Cited by
Sorted by citations
Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?
Kariuki, S., Kering, K., Wairimu, C., Onsare, R., & Mbae, C. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s342753 · Cited by 231 · see citing works
Danso, E. K., Asare, P., Otchere, I. D., Akyeh, L. M., Asante-Poku, A., Aboagye, S. Y., Osei-Wusu, S., Opare, D., Ntoumi, F., Zumla, A., et al. (2020) · PLOS ONE · doi:10.1371/journal.pone.0236016 · Cited by 28 · see citing works
- Authors
- Thompson, C. C., Freitas, F. S., Marin, M. A., Fonseca, E. L., Okeke, I. N., & Vicente, A. C. P.
- Affiliations
- Instituto Oswaldo Cruz (BR)
- Haverford College (US)
- Corresponding author
- Vicente, Ana Carolina P.
- Venue
- Infection, Genetics and Evolution
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 11
- Issue
- 8
- Pages
- 1951-1956
- ISSN
- 1567-1348 (ISSN-L)
- OpenAlex
- W2079796452
- Cited by
- 29
- References
- 0
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 2 · 2017: 1 · 2016: 3 · 2015: 4 · 2014: 3 · 2013: 3 · 2012: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Infection Genetics and Evolution (publishedVersion)
- PubMed (publishedVersion)
- Arca - Repositório Institucional da Fiocruz (submittedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Vibrio bacteria research studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Vibrio cholerae O1, seventh cholera pandemic, cholera outbreak, Ghana, El Tor, multilocus sequence analysis, ctxB gene, antibiotic resistance, aminoglycoside resistance, class 2 integron, bacterial evolution
- MeSH terms
- Base Sequence, Cholera, DNA, Bacterial, Multigene Family, Ghana, Humans, Molecular Sequence Data, Phylogeny, Vibrio cholerae O1, Pandemics
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
