A molecular and epidemiological study of Vibrio cholerae isolates from cholera outbreaks in southern Ghana
Open accessAbstract
Cholera remains a major global public health threat and continuous emergence of new Vibrio cholerae strains is of major concern. We conducted a molecular epidemiological study to detect virulence markers and antimicrobial resistance patterns of V. cholerae isolates obtained from the 2012-2015 cholera outbreaks in Ghana. Archived clinical isolates obtained from the 2012, 2014 and 2015 cholera outbreaks in Ghana were revived by culture and subjected to microscopy, biochemical identification, serotyping, antibiotic susceptibility testing, molecular detection of distinct virulence factors and Multi-Locus Variable-Number of Tandem-Repeat Analysis (MLVA). Of 277 isolates analysed, 168 (60.6%) were confirmed to be V. cholerae and 109 (39.4%) isolates constituted other bacteria (Escherichia coli, Aeromonas sobria, Pseudomonas aeruginosa, Enterobacter cloacae and Enterococci faecalis). Serotyping the V. cholerae isolates identified 151 (89.9%) as Ogawa, 3 (1.8%) as Inaba and 14 (8.3%) as non-O1/O139 serogroup. The O1 serogroup isolates (154/168, 91.7%) carried the cholera toxin ctxB gene as detected by PCR. Additional virulence genes detected include zot, tcpA, ace, rtxC, toxR, rtxA, tcpP, hlyA and tagA. The most common and rare virulence factors detected among the isolates were rtxC (165 isolates) and tcpP (50 isolates) respectively. All isolates from 2014 and 2015 were multidrug resistant against the selected antibiotics. MLVA differentiated the isolates into 2 large unique clones A and B, with each predominating in a particular year. Spatial analysis showed clustering of most isolates at Ablekuma sub-district. Identification of several virulence genes among the two different genotypes of V. cholerae isolates and resistance to first- and second-line antibiotics, calls for scaleup of preventive strategies to reduce transmission, and strengthening of public health laboratories for rapid antimicrobial susceptibility testing to guide accurate treatment. Our findings support the current WHO licensed cholera vaccines which include both O1 Inaba and Ogawa serotypes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the past decade, Vibrio cholerae isolates have become resistant to penicillins, aminoglycosides and sulfonamides, quinolones, tetracycline, macrolides, and phenicols.
“In the past decade, V. cholerae isolates have become resistant to penicillins, aminoglycosides and sulfonamides, quinolones, tetracycline, macrolides, and phenicols”
From Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now? (2022) · cites this paper as [57]
The Results (§3.2; page unavailable) report increasing resistance among V. cholerae isolates from southern Ghana’s 2012, 2014 and 2015 outbreaks. The Discussion (§4; page unavailable) identifies resistance to a sulfonamide combination, a quinolone, erythromycin, doxycycline and chloramphenicol. The paper does not establish the claimed resistance to aminoglycosides or a general trend across the past decade; testing a drug, as described in Methods (§2.2), does not itself show resistance to it. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Yu, G., Smith, D. K., Zhu, H., Guan, Y., & Lam, T. T. (2016) · Methods in Ecology and Evolution · doi:10.1111/2041-210x.12628 · Cited by 4,821 · see citing works
Kaper, J. B., Morris, J. G., & Levine, M. M. (1995) · Clinical Microbiology Reviews · doi:10.1128/cmr.8.1.48 · Cited by 1,245 · see citing works
Staden, R., Beal, K. F., & Bonfield, J. (2003) · Humana Press eBooks · doi:10.1385/1-59259-192-2:115 · Cited by 1,097 · see citing works
Nandi, B., Nandy, R. K., Mukhopadhyay, S., Nair, G. B., Shimada, T., & Ghose, A. C. (2000) · Journal of Clinical Microbiology · doi:10.1128/jcm.38.11.4145-4151.2000 · Cited by 359 · see citing works
Genomic history of the seventh pandemic of cholera in Africa
Weill, F., Domman, D., Njamkepo, E., Tarr, C. L., Rauzier, J., Fawal, N., Keddy, K. H., Salje, H., Moore, S., Mukhopadhyay, A. K., et al. (2017) · Science · doi:10.1126/science.aad5901 · Cited by 337 · see citing works
Mengel, M. A., Delrieu, I., Heyerdahl, L. W., & Gessner, B. D. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_369 · Cited by 149 · see citing works
Poulou, A., Grivakou, E., Vrioni, G., Koumaki, V., Pittaras, T., Pournaras, S., & Tsakris, A. (2014) · Journal of Clinical Microbiology · doi:10.1128/jcm.03361-13 · Cited by 134 · see citing works
Marin, M. F. A., Thompson, C. C., Freitas, F. S., da Fonseca, E. L., Aboderin, A. O., Zailani, S. B., Quartey, N. K. E., Okeke, I. N., & Vicente, A. C. P. (2013) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0002049 · Cited by 121 · see citing works
Vibrio choleraeNon-O1, Non-O139 Serogroups and Cholera-like Diarrhea, Kolkata, India
Dutta, D., Chowdhury, G., Pazhani, G. P., Guin, S., Dutta, S., Ghosh, S., Rajendran, K., Nandy, R. K., Mukhopadhyay, A. K., Bhattacharya, M. K., et al. (2013) · Emerging infectious diseases · doi:10.3201/eid1903.121156 · Cited by 112 · see citing works
Ahmed, H. A., Bayomi, R. M. E., Hussein, M. A., Khedr, M. H. E., Remela, E. M. A., & El‐Ashram, A. (2018) · International Journal of Food Microbiology · doi:10.1016/j.ijfoodmicro.2018.03.013 · Cited by 104 · see citing works
Kumar, P., Jain, M., Goel, A. K., Bhadauria, S., Sharma, S., Kamboj, D. V., Singh, L., Ramamurthy, T., & Nair, G. B. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.002089-0 · Cited by 98 · see citing works
Diagnostic Limitations to Accurate Diagnosis of Cholera
Alam, M., Hasan, N. A., Sultana, M., Nair, G. B., Sadique, A., Faruque, A. S. G., Endtz, H. P., Sack, R. B., Huq, A., Colwell, R. R., et al. (2010) · Journal of Clinical Microbiology · doi:10.1128/jcm.00616-10 · Cited by 97 · see citing works
Cholera in Coastal Africa: A Systematic Review of Its Heterogeneous Environmental Determinants
Rebaudet, S., Súdre, B., Faucher, B., & Piarroux, R. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit202 · Cited by 85 · see citing works
Vibrio cholerae Strain Typing and Phylogeny Study Based on Simple Sequence Repeats
Danin‐Poleg, Y., Cohen, L. A., Gancz, H., Broza, Y. Y., Goldshmidt, H., Malul, E., Valinsky, L., Lerner, L., Broza, M., & Kashi, Y. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.01895-06 · Cited by 80 · see citing works
Baloi, L. D., Baltazar, C. S., Manhique-Coutinho, L. V., Chitio, J. J. E., Inguane, D., & Langa, J. P. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181496 · Cited by 71 · see citing works
Nguyen, V. D., Sreenivasan, N., Lam, E., Ayers, T., Kargbo, D., Dafae, F. M., Jambai, A., Alemu, W., Kamara, A., Islam, M. S., et al. (2014) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.13-0567 · Cited by 63 · see citing works
Molecular analysis of non-O1/non-O139 Vibrio choleraeisolated from hospitalised patients in China
Luo, Y., Ye, J., Jin, D., Ding, G., Zhang, Z., Mei, L., Octavia, S., & Lan, R. (2013) · BMC Microbiology · doi:10.1186/1471-2180-13-52 · Cited by 60 · see citing works
The tide of antimicrobial resistance and selection
Wilcox, M. H. (2009) · International Journal of Antimicrobial Agents · doi:10.1016/s0924-8579(09)70550-3 · Cited by 55 · see citing works
Emergence of multiple drug resistance Vibrio cholerae O1 in East Delhi
Das, S., Choudhry, S., Saha, R., Ramachandran, V. G., Kaur, K., & Sarkar, B. L. (2011) · The Journal of Infection in Developing Countries · doi:10.3855/jidc.1251 · Cited by 46 · see citing works
Sarkar, A., Nandy, R. K., Nair, G. B., & Ghose, A. C. (2002) · Infection and Immunity · doi:10.1128/iai.70.8.4735-4742.2002 · Cited by 45 · see citing works
Eibach, D., Herrera-León, S., Gil, H., Hogan, B., Ehlkes, L., Adjabeng, M. J., Kreuels, B., Nagel, M., Opare, D. A., Fobil, J. N., et al. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0004751 · Cited by 44 · see citing works
Self-citationAbana, D., Gyamfi, E., Dogbe, M., Opoku, G., Opare, D., Boateng, G., & Mosi, L. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-3714-z · Cited by 42 · see citing works
Self-citationCholera Epidemiology in Mozambique Using National Surveillance Data
Gujral, L., Sema, C., Rebaudet, S., Taibo, C. L. A., Manjate, A. A., Piarroux, R., Gessner, B. D., & Jani, I. V. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit212 · Cited by 41 · see citing works
Morita, M., Ohnishi, M., Arakawa, E., Yamamoto, S., Nair, G. B., MATSUSHITA, S., Yokoyama, K., Akemi, K. A. I., Seto, K., Watanabe, H., et al. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.017624-0 · Cited by 30 · see citing works
Dynamics of cholera epidemics from Benin to Mauritania
Moore, S., Dongdem, A. Z., Opare, D. A., Cottavoz, P., Fookes, M. C., Sadji, A. Y., Dzotsi, E. K., Dogbe, M., Jeddi, F., Bidjada, B., et al. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006379 · Cited by 29 · see citing works
Self-citationVibrio cholerae O1 lineages driving cholera outbreaks during seventh cholera pandemic in Ghana
Thompson, C. C., Freitas, F. S., Marin, M. A., Fonseca, E. L., Okeke, I. N., & Vicente, A. C. P. (2011) · Infection, Genetics and Evolution · doi:10.1016/j.meegid.2011.08.020 · Cited by 29 · see citing works
Large cholera outbreak in Brong Ahafo Region, Ghana
Noora, C. L., Issah, K., Kenu, E., Bachan, E. G., Nuoh, R. D., Nyarko, K. M., Appiah, P. C., & Letsa, T. S. (2017) · BMC Research Notes · doi:10.1186/s13104-017-2728-0 · Cited by 27 · see citing works
Garrine, M., Mandomando, I., Vubil, D. C., Nhampossa, T., Acácio, S., Li, S., Paulson, J. N., Almeida, M., Domman, D., Thomson, N. R., et al. (2017) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005671 · Cited by 27 · see citing works
Alam, M. T., Ray, S. S., Chun, C. N., Chowdhury, Z. G., Rashid, M. H., de Rochars, V. E. M. B., & Ali, A. (2016) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0005045 · Cited by 26 · see citing works
Ngandjio, A., Tejiokem, M. C., Wouafo, M., Ndome, I., Yonga, M. G. W., Guénolé, A., Lemée, L., Quilici, M., & Fonkoua, M. (2008) · Foodborne Pathogens and Disease · doi:10.1089/fpd.2008.0127 · Cited by 24 · see citing works
Das, S. K., Chisti, M. J., Huq, S., Malek, M. A., Vanderlee, L., Kaur, G., Salam, M. A., Ahmed, T., Faruque, A. S. G., & Mamun, A. A. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070402 · Cited by 23 · see citing works
Feglo, P. K., & Sewurah, M. (2018) · BMC Research Notes · doi:10.1186/s13104-017-2923-z · Cited by 23 · see citing works
Oyedeji, K. S., Niemogha, M.-T., Nwaokorie, F. O., Bamidele, T. A., Ochogo, M., Akinsinde, K. A., Brai, B. I. C., Oladele, D. A., Omonigbehin, E. A., Bamidele, M., et al. (2013) · Journal of Health Population and Nutrition · doi:10.3329/jhpn.v31i2.16381 · Cited by 22 · see citing works
Sk, R., Islam, A., Ali, R., Islam, K. E., Khan, R., Ara, S. H., Saifuddin, N. M., & Fuchs, G. J. (1998) · Transactions of the Royal Society of Tropical Medicine and Hygiene · doi:10.1016/s0035-9203(98)91094-x · Cited by 20 · see citing works
Bhattacharya, D., Dey, S., Pazhani, G. P., Ramamurthy, T., Parande, M. V., Kholkute, S. D., & Roy, S. (2015) · Medical Microbiology and Immunology · doi:10.1007/s00430-015-0433-y · Cited by 19 · see citing works
Genetic diversity of toxigenic Vibrio cholerae O1 from Sabah, Malaysia 2015
Zaw, M. T., Emran, N. A., Ibrahim, M. Y., Suleiman, M., Mohd, T. A. A., Yusuff, A. S. M., Naing, K. S., Myint, T., Jikal, M., Salleh, M. A., et al. (2018) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2018.01.003 · Cited by 15 · see citing works
Bhowmick, T. S., Das, M., Ruppitsch, W., Stoeger, A., Pietzka, A. T., Allerberger, F. J., Rodrigues, D. P., & Sarkar, B. L. (2009) · Journal of Medical Microbiology · doi:10.1099/jmm.0.008466-0 · Cited by 14 · see citing works
Goulart, C. L., dos Santos, G. G., Barbosa, L. C., Lery, L. M. S., Bisch, P. M., & von Krüger, W. M. A. (2010) · Microbiology · doi:10.1099/mic.0.043117-0 · Cited by 12 · see citing works
Characterization of Vibrio cholerae Strains Isolated from the Nigerian Cholera Outbreak in 2010
Dupke, S., Akinsinde, K. A., Grunow, R., Iwalokun, B. A., Olukoya, D. K., Oluwadun, A., Velavan, T. P., & Jacob, D. (2016) · Journal of Clinical Microbiology · doi:10.1128/jcm.01467-16 · Cited by 9 · see citing works
Antibiotic resistance patterns amongst clinical Vibrio cholerae O1 isolates from Accra, Ghana
Kuma, G. K., Opintan, J. A., Sackey, S. O., Nyarko, K. M., Opare, D. A., Aryee, E. A. N., Dongdem, A. Z., Antwi, L., Ofosu-Appiah, L. H., Owusu-Okyere, G., et al. (2014) · International journal of infection control · doi:10.3396/ijic.v10i3.13152 · Cited by 7 · see citing works
Self-citationYeboah‐Manu, D. (2013) · Mycobacterial Diseases · doi:10.4172/2161-1068.1000107 · Cited by 4 · see citing works
Self-citationLessons from Vibrio Pathogen and the Comparative Study of Vaccines Developed
Rahman, T., Seraj, M. F., & Buroni, S. (2018) · Advances in Microbiology · doi:10.4236/aim.2018.812064 · Cited by 2 · see citing works
Moaddab, A. R. S. R. (2012) · Mycobacterial Diseases · doi:10.4172/2161-1068.1000119 · Cited by 1 · see citing works
Flagged first, then by citations
1 of the 44 references couldn’t be matched to a known paper.
Research works printed but not linked: 3
- Ghana weekly epidemiological bulletin [Internet]. 2015 [cited 2018/11/2]. http://www.ghanahealthservice.org/downloads/Weekly_Epid_Bulletin_Week_1_2015.pdf.
- Y Luo, 2013, Molecular analysis of non-O1/non-O139 Vibrio cholerae isolated from hospitalised patients in China, BMC Microbiol, 13, 52, 10.1186/1471-2180-13-52 · DOI
- Acolatse CRY. Occurrence Of Cholera In Some Parts Of The Ablekuma Sub-Metro District Of Accra, Ghana, And Its Socio-Economic Impact On The People Of The Community. University of Ghana Thesis Collection. 2007.
Cited by
Sorted by citations
Antimicrobial Resistance Rates and Surveillance in Sub-Saharan Africa: Where Are We Now?
Kariuki, S., Kering, K., Wairimu, C., Onsare, R., & Mbae, C. (2022) · Infection and Drug Resistance · doi:10.2147/idr.s342753 · Cited by 231 · see citing works
Afum, T., Asandem, D. A., Asare, P., Asante-Poku, A., Mensah, G. I., Musah, A. B., Opare, D., Taniguchi, K., Guinko, N. M., Aphour, T., et al. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.894319 · Cited by 32 · see citing works
Self-citationBitew, A., Gelaw, A., Wondimeneh, Y., Ayenew, Z., Getie, M., Tafere, W., eyesus, T. G., Yimer, M., Beyene, G. T., Bitew, M., et al. (2024) · BMC Public Health · doi:10.1186/s12889-024-19621-4 · Cited by 18 · see citing works
Chen, D., Li, X., Ni, L., Xu, D., Xu, Y., Ding, Y., Xie, L., & Chen, L. (2021) · Antibiotics · doi:10.3390/antibiotics10040412 · Cited by 16 · see citing works
Mavhungu, M., Digban, T. O., & Nwodo, U. U. (2023) · Microorganisms · doi:10.3390/microorganisms11102449 · Cited by 14 · see citing works
Advances in phage display based nano immunosensors for cholera toxin
Li, Y., Yang, K., Kong, D.-C., & Ye, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1224397 · Cited by 13 · see citing works
Liu, C., Wang, Y., Azizian, K., Omidi, N., Kaviar, V. H., Kouhsari, E., & Maleki, A. (2022) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2022.2098114 · Cited by 10 · see citing works
Outbreak of Cholera in Ghana: A Systematic Review from 2010 to 2020
Apenteng, J. A., Korsah, S., Tagoe, M., Nortey, N. N. D., Korsah, J., Wobetsey, B. D., & Owusu, F. W. A. (2023) · Asian Journal of Research in Infectious Diseases · doi:10.9734/ajrid/2023/v13i2261 · Cited by 8 · see citing works
Alhassan, J., Appiah, D. O., Iddrisu, S., Ofosu, A., & Tetteh, J. (2024) · Cogent Social Sciences · doi:10.1080/23311886.2024.2433691 · Cited by 8 · see citing works
Maji, S., Ghotekar, B. K., & Kulkarni, S. S. (2024) · Organic Letters · doi:10.1021/acs.orglett.3c04225 · Cited by 8 · see citing works
Toxigenic Vibrio cholerae strains in South-East Queensland, Australian river waterways
Bhandari, M., Rathnayake, I. U., Ariotti, L., Heron, B. A., Huygens, F., Sullivan, M., & Jennison, A. V. (2023) · Applied and Environmental Microbiology · doi:10.1128/aem.00472-23 · Cited by 7 · see citing works
Kungu, F., Yartey, S. N.-A., Asantewaa, A. A., & Donkor, E. S. (2025) · International Health · doi:10.1093/inthealth/ihaf069 · Cited by 6 · see citing works
Phylogenetic and antimicrobial drug resistance analysis of Vibrio cholerae O1 isolates from Ghana
Opintan, J. A., Will, R. C., Kuma, G. K., Osei, M., Akumwena, A., Boateng, G., Owusu-Okyere, G., Antwi, L., Opare, D. A., Pragasam, A. K., et al. (2021) · Microbial Genomics · doi:10.1099/mgen.0.000668 · Cited by 6 · see citing works
Self-citationIribarren, C., Plaza, N., Ramírez-Araya, S., Pérez-Reytor, D., Urrutia, Í. M., Suffredini, E., Vicenza, T., Ulloa, S., Fernández, J., Navarrete, P., et al. (2024) · Microorganisms · doi:10.3390/microorganisms12030504 · Cited by 5 · see citing works
Anas, A., Vikraman, H. K., Raj, D., Menon, N. R., George, G., Soman, R., Deepulal, P. M., Ann, M., Krishna, K. S., Raju, G. K. T., et al. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-30565-x · Cited by 4 · see citing works
Abdulmughni, G. T., Al-Moyed, K. A., Al-gunaid, E. A., Al-Shami, H. Z., Al-Haidary, N. M., Al-Madhaji, A. G., & Al-Shamahy, H. A. (2024) · Universal Journal of Pharmaceutical Research · doi:10.22270/ujpr.v9i2.1083 · Cited by 3 · see citing works
Mideksa, G., Botore, A., & Abdo, B. (2024) · Research Square · doi:10.21203/rs.3.rs-4483047/v1 · Cited by 3 · see citing works
Akpo, E., Dougnon, V. T., Agbankpe, A. J., & Bankole, H. S. (2021) · Journal of Microbiology and Antimicrobials · doi:10.5897/jma2020.0440 · Cited by 1 · see citing works
Ali, J. H., Bekele, M., Botore, A., Mannekulih, E., Kenate, B., Kibebew, T., Bafikadu, C., Zewdie, A., Worku, D., Shumi, G., et al. (2026) · BMC Infectious Diseases · doi:10.1186/s12879-026-13580-4 · Cited by 1 · see citing works
Jaiswal, S., Panja, A. K., & Haldar, S. (2024) · Environmental Science and Pollution Research · doi:10.1007/s11356-024-34391-7 · Cited by 1 · see citing works
Genomic and virulence studies of Vibrio cholerae O1 and Non-O1, Non-O139 in Queensland Australia
Bhandari, M. (2023) · Queensland University of Technology · doi:10.5204/thesis.eprints.242763 · Cited by 1 · see citing works
Denon, Y. E., Désirée, M., Odoun, M., Agbankpe, A. J., Dougnon, V. T., Assogba, R., Pascaline, M., Germaine, W., & Bankole, H. S. (2021) · African Journal of Microbiology Research · doi:10.5897/ajmr2020.9474
Duodu, S., Ansa, G., & Opintan, J. A. (2025) · Cambridge University Press eBooks · doi:10.1017/9781009052733.039
Self-citationChataa, P., Naandam, S. M., Oduro, B., & Ameko, F. (2026) · Mathematical Methods in the Applied Sciences · doi:10.1002/mma.70738
A One-Health Perspective on Enterococcus in Ghana: A Review and Meta-Analysis
Aglomasa, B. C., Sarkodie-Addo, P., Semevor, G. O., & Donkor, E. S. (2026) · Environmental Health Insights · doi:10.1177/11786302261455118
Recent Advances in Synthesis and Applications of Fluorinated Sugars: A Mini Review
Maji, S., Dcosta, C., & Kulkarni, S. S. (2026) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.70235
Senga, R. K. K., Mukuku, O. K., Iyombe, J.-P. E., Lufulwabo, J. K., Kakongo, D. K., Tsongo, Z. K., & Wembonyama, S. O. (2026) · Tropical Medicine and Health · doi:10.1186/s41182-026-01019-0
Shirsat, A. A., Behera, S., & Kulkarni, S. S. (2026) · Chemistry - A European Journal · doi:10.1002/chem.71718
- Authors
- Danso, E. K., Asare, P., Otchere, I. D., Akyeh, L. M., Asante-Poku, A., Aboagye, S. Y., Osei-Wusu, S., Opare, D., Ntoumi, F., Zumla, A., Duodu, S., & Yeboah-Manu, D.
- Affiliations
- University of Ghana (GH)
- Fondation Congolaise Pour La Recherche Médicale (CG)
- UCL Biomedical Research Centre (GB)
- ORCID
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2020-07-10
- Volume
- 15
- Issue
- 7
- Pages
- e0236016
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC7351161
- OpenAlex
- W3042118802
- Cited by
- 28
- References
- 44
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 3 · 2021: 4
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- PANDORA-ID-NET funded EDCTP (RIA2016E-1609)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Vibrio bacteria research studies
- Life Sciences › Agricultural and Biological Sciences › Food Science › Salmonella and Campylobacter epidemiology
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Vibrio cholerae, cholera outbreak, virulence genes, antimicrobial resistance, MLVA genotyping, serotyping, ctxB, TCPP, multidrug resistance, spatial clustering, outbreak clone, cholera vaccine, southern Ghana
- MeSH terms
- Anti-Bacterial Agents, Cholera, Cholera Toxin, Disease Outbreaks, Ghana, Humans, Microbial Sensitivity Tests, Phylogeny, Vibrio cholerae, Virulence, Tandem Repeat Sequences, Drug Resistance, Multiple, Bacterial, Serogroup
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
