Can suicide behavior and seasonality of suicide be predicted from inflammatory parameters in adolescents?
Abstract
According to the 2017 data of World Health organization approximately 800 million individuals commit suicide annually. After understanding that psychiatric disorders start the inflammation process by suppressing the brain, a number of studies using neutrophil/lymphocyte ratio, platelet/lymphocyte ratio and monocyte/lymphocyte ratio have been conducted. Platelet/lymphocyte ratio, neutrophil/lymphocyte ratio, monocyte/lymphocyte ratio and other hemogram parameters may be a marker in predicting suicide. In addition, the determination of the relationship between these inflammatory markers and the cyclicity/seasonality of suicide can provide a basis for preventive mental health measures. This hypothesis was performed on 193 patients who attempted suicide and the control group consisted of 109 healthy children and adolescents between 2014 and 2019. Data were evaluated by SPSS software version 22 and a value of p < 0.05 was accepted to be significant in all tests. In our study, we found that hemogram parameters showing inflammation were significantly higher in the patients who committed suicide. Another finding of this study is that inflammation is directly related to suicide attempt rather than seasonality in adolescents who commit suicide. Rigorous testing of this medical hypothesis with other research will have major clinical and policy implications for preventive mental health.
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MLR was significantly higher in adolescents with suicide attempt than in healthy controls.
“MLR was significantly higher in adolescents with SA than in HC [23].”
Regarding PLR, two studies reported that PLR was higher in depressed patients (including SA, SI, and nSI) vs HC.
“Regarding the PLR index, two studies reported that PLR was higher in depressed patients (including SA, SI, and nSI) vs HC [23, 30].”
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Brain-immune communication pathways
Quan, N., & Banks, W. A. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.05.005 · Cited by 626 · see citing works
The role of cytokines in the pathophysiology of suicidal behavior
Ganança, L., Oquendo, M. A., Tyrka, A. R., Cisneros-Trujillo, S., Mann, J. J., & Sublette, M. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.008 · Cited by 217 · see citing works
Özdin, S., Sarisoy, G., & Böke, Ö. (2017) · Nordic Journal of Psychiatry · doi:10.1080/08039488.2017.1340517 · Cited by 148 · see citing works
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Velasco, A., Lengvenyte, A., Rodriguez-Revuelta, J., Jimenez-Treviño, L., Courtet, P., Garcia-Portilla, M., Bobes, J., & Sáiz, P. (2024) · European Psychiatry · doi:10.1192/j.eurpsy.2023.18 · Cited by 34 · see citing works
Child and Adolescent Psychiatry, U. O. H. S., Önen, Ö., Erkuran, H. Ö., Child and Adolescent Psychiatry, U. O. H. S., Bağ, Ö., Department of Social Pediatrics, U. O. H. S., Abacıgil, F., & Department of Public Health, A. A. M. U. F. O. M. (2021) · Psychiatry and Clinical Psychopharmacology · doi:10.5152/pcp.2021.21137 · Cited by 13 · see citing works
- Authors
- Ucuz, İ., & Kayhan Tetik, B.
- Affiliations
- Inonu University (TR)
- ORCID
- Ucuz, İlknur
- Venue
- Medical Hypotheses
- Publisher
- Elsevier BV
- Published
- 2020-10
- Volume
- 143
- Pages
- 110061
- ISSN
- 0306-9877 (ISSN-L)
- OpenAlex
- W3039689618
- Cited by
- 27
- References
- 3
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 7 · 2022: 3 · 2021: 3 · 2020: 1
- FWCI
- 1.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Hypotheses (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
- Keywords
- suicide, suicide attempts, inflammatory markers, hematological parameters, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, adolescents, suicide risk prediction, mental health prevention
- MeSH terms
- Adolescent, Blood Platelets, Child, Humans, Lymphocytes, Monocytes, Neutrophils, Suicide, Attempted
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