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Cited by 153Adipokines, Inflammation, and Metabolic DiseasesDiabetes, Cardiovascular Risks, and LipoproteinsInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.

Low-grade inflammation may play a role in the etiology of the metabolic syndrome in patients with coronary heart disease: the HIFMECH study

Yudkin, J.S, Juhan-Vague, I, Hawe, E, Humphries, S.E, di Minno, G, Margaglione, M, Tremoli, E, Kooistra, T, Morange, P.E, Lundman, P, Mohamed-Ali, V, Hamsten, A·2004·Metabolism
DOI 10.1016/j.metabol.2004.02.004
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Abstract

Risk of coronary heart disease has been related to insulin resistance, but the mechanism for this is incompletely understood. Variables attributed to insulin resistance are associated with low-grade inflammation. A case-control study was performed of 469 male myocardial infarction (MI) survivors aged < 60 years and 575 control subjects recruited from centers in northern and southern Europe. Principal factor analysis was used to explore correlations between insulin resistance and inflammatory variables. Three factors resulted: (a) "Metabolic Syndrome" (insulin/proinsulin/ triglyceride/body mass index [BMI]); (b) "Inflammation" (fibrinogen/C-reactive protein [CRP]/interleukin-6 [IL-6]); and (c) "Blood Pressure" (systolic and diastolic blood pressure). The "Metabolic Syndrome" factor was related to the "Inflammation" factor (largely independently of obesity), the "Blood Pressure" factor, smoking, and south location (all P < or = .0002). There were significant relationships between all 3 factors and case status (P < or = .0002). Markers of low-grade inflammation are strongly related to metabolic syndrome variables independently of obesity. This raises the possibility that links between insulin resistance and cardiovascular disease could, in part, represent common consequences of low-grade inflammation.

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Authors
Yudkin, J. S., Juhan-Vague, I., Hawe, E., Humphries, S. E., di Minno, G., Margaglione, M., Tremoli, E., Kooistra, T., Morange, P. E., Lundman, P., Mohamed-Ali, V, & Hamsten, A.
Affiliations
  • University College London (GB)
  • The Royal Free Hospital (GB)
  • Casa Sollievo della Sofferenza (IT)
  • University of Milan (IT)
  • Netherlands Organisation for Applied Scientific Research (NL)
  • Hôpital de la Timone (FR)
  • Karolinska University Hospital (SE)
Corresponding author
Yudkin, J.S
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2004-07
Volume
53
Issue
7
Pages
852-857
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2004.02.004
OpenAlex
W2123585924
Cited by
153
References
40
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 7 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 4 · 2015: 7 · 2014: 8 · 2013: 9 · 2012: 4
FWCI
11.69
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
low-grade inflammation, metabolic syndrome, coronary artery disease, insulin resistance, myocardial infarction survivors, C-reactive protein, fibrinogen, interleukin-6, blood pressure, obesity
MeSH terms
Aged, Blood Pressure, Coronary Disease, Europe, Factor Analysis, Statistical, Fibrinolysis, Humans, Inflammation, Male, Middle Aged, Myocardial Infarction, Risk Factors, Cohort Studies, Body Mass Index, Cluster Analysis, Survivors, Thrombophilia, Metabolic Syndrome

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