Cited by 2,113Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityAdipose Tissue and Metabolism

Adipose Tissue, Inflammation, and Cardiovascular Disease

Berg, Anders H., Scherer, Philipp E.·2005·Circulation Research

Abstract

Mounting evidence highlights the role of adipose tissue in the development of a systemic inflammatory state that contributes to obesity-associated vasculopathy and cardiovascular risk. Circulating mediators of inflammation participate in the mechanisms of vascular insult and atheromatous change, and many of these inflammatory proteins are secreted directly from adipocytes and adipose tissue–derived macrophages. Several factors linking obesity with an increased cardiovascular risk have been identified. The adipocyte-specific secretory protein adiponectin is a particularly promising candidate in this context. Its levels are decreased in obesity. Adiponectin may mediate some of its demonstrated cardioprotective effects through its anti-inflammatory properties. In addition to decreased expression of beneficial adipokines, secretion of a host of inflammatory factors from visceral adipose tissue may contribute to the increased cardiovascular risk associated with obesity. The cardioprotective effects of many of the most popular drug regimens corroborate these conclusions, demonstrating that along with improvements in other therapeutic end points, they mediate improvements in systemic inflammation. In some cases, these improvements are attributable to direct suppression of inflammatory signaling in adipocytes. The targeted suppression of various proinflammatory cascades in adipocytes specifically represents an exciting new therapeutic opportunity for the cardiovascular disease area.

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  1. [64]64. Steensberg A. The role of IL-6 in exercise-induced immune changes and metabolism. Exerc Immunol Rev. 2003;9:40 -47.
  2. [70]70. Emanueli C, Madeddu P. Renin-angiotensin and kallikrein-kinin systems coordinately modulate angiogenesis. Hypertension. 2002; 39:e29.

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Authors
Berg, A. H., & Scherer, P. E.
Affiliations
Brigham and Women's Hospital (US)
Venue
Circulation Research
Published
2005-05-13
Volume
96
Issue
9
Pages
939-949
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
OpenAlex
W2133481218
Cited by
2,113
References
134
Citations by year
2026: 30 · 2025: 70 · 2024: 48 · 2023: 63 · 2022: 86 · 2021: 106 · 2020: 103 · 2019: 79 · 2018: 83 · 2017: 114 · 2016: 140 · 2015: 121 · 2014: 153 · 2013: 154 · 2012: 126
FWCI
13.68
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • American Diabetes Association
  • National Institutes of Health
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK 55758, R01DK055758)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords
adipose tissue, systemic inflammation, obesity, cardiovascular risk, adiponectin, adipocytes, adipokines, atherosclerosis, vascular dysfunction, cardioprotection, anti-inflammatory therapy, pro-inflammatory signaling
MeSH terms
Adipose Tissue, Cardiovascular Diseases, Humans, Immunity, Innate, Inflammation, Insulin Resistance, Obesity, Weight Loss, Panniculitis, Cytokines, Metabolic Syndrome

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