Limitation of the validity of the homeostasis model assessment as an index of insulin resistance in Korea
Open accessAbstract
Homeostasis model assessment of insulin resistance (HOMA-IR) is a less invasive, inexpensive, and less labor-intensive method to measure insulin resistance (IR) as compared with the glucose clamp test. The aim of this study was to evaluate the validity of HOMA-IR by comparing it with the euglycemic clamp test in determining IR. We assessed the validity of HOMA-IR by comparing it with the total glucose disposal rate measured by the 3-hour euglycemic-hyperinsulinemic clamp in subjects with type 2 diabetes (n = 47), impaired glucose tolerance (n = 21), and normal glucose tolerance (n = 22). There was a strong inverse correlation (r = -0.558; P or =25.0 kg/m2 , r = -0.615; P = .032), a lower HOMA-beta cell function (HOMA- beta or =60.0, r = -0.686; P = .016), and higher fasting glucose levels (fasting glucose 5.66 mmol/L, r = -0.520; P = .039). The limitation of the validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, a lower beta cell function, and high fasting glucose levels such as lean type 2 diabetes mellitus with insulin secretory defects.
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The validity of HOMA-IR should be carefully considered in subjects with a lower BMI, lower beta cell function, and high fasting plasma glucose such as in T2DM with the insulin secretory defect.
“The validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, lower beta cell function, and high FPG such as in T2DM with the insulin secretory defect [21].”
From Optimal Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) Cut-Offs: A Cross-Sectional Study in the Czech Population (2019) · cites this paper as [21]
Cites
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Disproportionately Elevated Proinsulin in Pima Indians with Noninsulin-Dependent Diabetes Mellitus*
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Limitations in the Use of Indices Using Glucose and Insulin Levels to Predict Insulin Sensitivity
Pisprasert, V., Ingram, K. H., Lopez-Davila, M. F., Munoz, A. J., & Garvey, W. T. (2013) · Diabetes Care · doi:10.2337/dc12-0840 · Cited by 302 · see citing works
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“This may be due to the limitations of the validity of the HOMAIR in patients with lower BMI, lower beta-cell function, and higher fasting glucose levels [32].”
Self-citationHoráková, D., Štěpánek, L., Janout, V., Janoutová, J., Pastucha, D., Kollárová, H., Petráková, A., Štěpánek, L., Husár, R., & Martiník, K. (2019) · Medicina · doi:10.3390/medicina55050158 · Cited by 87 · see citing works
“The validity of the HOMA-IR should be carefully considered in subjects with a lower BMI, lower beta cell function, and high FPG such as in T2DM with the insulin secretory defect [21].”
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- Authors
- Kang, E. S., Yun, Y. S., Park, S. W., Kim, H. J., Ahn, C. W., Song, Y. D., Cha, B. S., Lim, S. K., Kim, K. R., & Lee, H. C.
- Affiliations
- Yonsei University (KR)
- University of Pittsburgh (US)
- Catholic Kwandong University (KR)
- National Health Insurance Service Ilsan Hospital (KR)
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2005-02
- Volume
- 54
- Issue
- 2
- Pages
- 206-211
- ISSN
- 0026-0495 (ISSN-L)
- OpenAlex
- W2003398096
- Cited by
- 161
- References
- 5
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 14 · 2023: 9 · 2022: 6 · 2021: 11 · 2020: 8 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 10 · 2015: 6 · 2014: 3 · 2013: 9 · 2012: 9
- FWCI
- 5.60
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Yonsei University College of Medicine
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- HOMA-IR, insulin resistance, hyperinsulinemic-euglycemic clamp, glucose disposal rate, type 2 diabetes, impaired glucose tolerance, body mass index, beta-cell function, fasting blood glucose, method validation, Korean population
- MeSH terms
- Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Homeostasis, Humans, Insulin, Insulin Resistance, Islets of Langerhans, Kinetics, Korea, Male, Middle Aged, Models, Biological, Pancreatic Function Tests, Reproducibility of Results, Glucose Clamp Technique, Body Mass Index, Glucose Intolerance
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