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Cited by 47Adipokines, Inflammation, and Metabolic DiseasesCardiovascular Disease and AdiposityPeripheral Artery Disease Management

Close association of hypoadiponectinemia with arteriosclerosis obliterans and ischemic heart disease

Kawano, Takahisa, Saito, Takako, Yasu, Takanori, Saito, Tomoyuki, Nakamura, Tomohiro, Namai, Kazuyuki, Tamemoto, Hiroyuki, Kawakami, Masanobu +2 more·2005·Metabolism
DOI 10.1016/j.metabol.2004.12.009
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Abstract

Adiponectin is an adipose-derived cytokine, and it is suggested that hypoadiponectinemia increases the prevalence of ischemic heart disease (IHD). The present study was undertaken to determine serum adiponectin levels in patients with arteriosclerosis obliterans (ASO) and IHD. Forty-nine patients with ASO and 49 age-, sex-, and body mass index-matched control subjects were examined. The diagnosis of ASO was derived from an ankle brachial index of less than 0.90 and stenotic or obstructive change in angiogram. Ischemic heart disease was diagnosed by ischemic or stenotic change in ECG, treadmill, or coronary angiogram. Serum adiponectin level was 8.6 +/- 0.9 microg/mL in the patients with ASO, a value significantly less than that of 12.4 +/- 1.0 microg/mL in the control subjects ( P < .01). Next, we subgrouped the subjects into 4 groups according to the presence of ASO and IHD. Serum adiponectin levels were 9.4 +/- 1.5 and 10.2 +/- 1.6 microg/mL in the subjects with ASO (n =23) and those with IHD (n = 13), respectively. It was further reduced to 7.9 +/- 1.2 microg/mL in the subjects having both ASO and IHD (n = 26), a value significantly less than that of 13.2 +/- 1.4 microg/mL in the control subjects (n = 36; P < .05). Serum high-density lipoprotein cholesterol was significantly less in the subjects with ASO than in the control subjects (42.1 +/- 1.7 vs 48.5 +/- 2.0 mg/dL; P < .05), but there were no differences in blood pressure, total cholesterol, low-density lipoprotein cholesterol, triglyceride, and uric acid levels. The present results indicate that a reduction in serum adiponectin level is associated with the prevalence and magnitude of systemic atherosclerosis including IHD and ASO.

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  • Clinical studies have established correlations between plasma adiponectin levels and various aspects and severity of heart failure.

    “First, an important pathophysiological contribution was suggested by the recent explosion in the number of clinical studies that have established correlations between plasma adiponectin levels and various aspects and severity of heart failure (107, 113, 143, 166, 172, 183, 198, 209, 251, 275, 282, 286, 303, 312, 366).”

    From Cardiac remodeling in obesity (2008) · cites this paper as [172]

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Authors
Kawano, T., Saito, T., Yasu, T., Saito, T., Nakamura, T., Namai, K., Tamemoto, H., Kawakami, M., Saito, M., & Ishikawa, S.-E.
Affiliations
Jichi Medical University (JP)
Corresponding author
Ishikawa, San-e
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2005-05
Volume
54
Issue
5
Pages
653-656
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2004.12.009
OpenAlex
W2097707283
Cited by
47
References
19
Citations by year
2023: 3 · 2017: 1 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 7 · 2012: 5
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
  • Health Sciences › Medicine › Surgery › Peripheral Artery Disease Management
Keywords
hypoadiponectinemia, adiponectin, arteriosclerosis obliterans, ischemic heart disease, systemic atherosclerosis, HDL cholesterol, serum adiponectin levels, peripheral arterial disease
MeSH terms
Adult, Aged, Aged, 80 and over, Arteriosclerosis Obliterans, Female, Humans, Cholesterol, HDL, Male, Middle Aged, Case-Control Studies, Myocardial Ischemia, Intercellular Signaling Peptides and Proteins, Adiponectin

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