CoChat
Sign Up
Cited by 232Chronic Kidney Disease and DiabetesDiabetes Treatment and ManagementNitric Oxide and Endothelin Effects

The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.

GLP-1 analog liraglutide protects against oxidative stress and albuminuria in streptozotocin-induced diabetic rats via protein kinase A-mediated inhibition of renal NAD(P)H oxidases

Open access
Hendarto, Hari, Inoguchi, Toyoshi, Maeda, Yasutaka, Ikeda, Noriko, Zheng, Jing, Takei, Ryoko, Yokomizo, Hisashi, Hirata, Eiichi, Sonoda, Noriyuki, Takayanagi, Ryoichi·2012·Metabolism
DOI 10.1016/j.metabol.2012.03.002
Open this paper in CoChat — free account

Abstract

Accumulating evidence has implicated that GLP-1 may have a beneficial effect on cardiovascular and renal diseases but the mechanism is not fully understood. Here we show that GLP-1 analog, liraglutide, inhibits oxidative stress and albuminuria in streptozotocin (STZ)-induced type 1 diabetes mellitus rats, via a protein kinase A (PKA)-mediated inhibition of renal NAD(P)H oxidases. Diabetic rats were randomly treated with subcutaneous injections of liraglutide (0.3 mg/kg/12 h) for 4 weeks. Oxidative stress markers (urinary 8-hydroxy-2'-deoxyguanosine and renal dihydroethidium staining), expression of renal NAD(P)H oxidase components, transforming growth factor-β (TGF-β), fibronectin and urinary albumin excretion were measured. In vitro effect of liraglutide was evaluated using cultured renal mesangial cells. Administration of liraglutide did not affect plasma glucose levels or body weights in STZ diabetic rats, but normalized oxidative stress markers, expression of NAD(P)H oxidase components, TGF-β, fibronectin in renal tissues and urinary albumin excretion, all of which were significantly increased in diabetic rats. In addition, in cultured renal mesangial cells, incubation with liraglutide for 48 h inhibited NAD(P)H-dependent superoxide production evaluated by lucigenin chemiluminescence in a dose-dependent manner. This effect was reversed by both PKA inhibitor H89 and adenylate cyclase inhibitor SQ22536, but not by Epac2 inhibition via its small interfering RNA. Liraglutide may have a direct beneficial effect on oxidative stress and diabetic nephropathy via a PKA-mediated inhibition of renal NAD(P)H oxidase, independently of a glucose-lowering effect.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.metabol.2012.03.002

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Show all 43 references

Cited by

Sorted by citations

Items 201–232 of 232

Related

See all

Metadata

Authors
Hendarto, H., Inoguchi, T., Maeda, Y., Ikeda, N., Zheng, J., Takei, R., Yokomizo, H., Hirata, E., Sonoda, N., & Takayanagi, R.
Affiliations
Kyushu University (JP)
Corresponding author
Inoguchi, Toyoshi
ORCID
Venue
Metabolism
Publisher
Elsevier BV
Published
2012-10
Volume
61
Issue
10
Pages
1422-1434
ISSN
0026-0495 (ISSN-L)
DOI
10.1016/j.metabol.2012.03.002
OpenAlex
W1983883248
Cited by
232
References
43
Citations by year
2026: 7 · 2025: 17 · 2024: 20 · 2023: 16 · 2022: 8 · 2021: 17 · 2020: 21 · 2019: 21 · 2018: 18 · 2017: 15 · 2016: 16 · 2015: 19 · 2014: 14 · 2013: 18 · 2012: 4
FWCI
13.96
Type
journal article
Language
en
Open access
Licence
Locations
  • Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Universitas Islam Negeri Syarif Hidayatullah Institutional Repository (Universitas Islam Negeri Syarif Hidayatullah Jakarta) (submittedVersion, cc-by-nc)
Funders
Japan Society for the Promotion of Science (23390247)
Topics
  • Health Sciences › Medicine › Nephrology › Chronic Kidney Disease and Diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
  • Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords
liraglutide, GLP-1 analogues, diabetic nephropathy, oxidative stress, albuminuria, protein kinase A, NADPH oxidase, type 1 diabetes, streptozotocin-induced diabetes, renal mesangial cells, superoxide production, TGF-beta, fibronectin, Epac2, renal fibrosis
MeSH terms
Liraglutide, Adenine, Albuminuria, Animals, Cells, Cultured, Diabetes Mellitus, Experimental, Diabetic Nephropathies, Humans, Isoquinolines, Kidney, Male, Multienzyme Complexes, NADH, NADPH Oxidoreductases, Streptozocin, Sulfonamides, Rats, Wistar, Cyclic AMP-Dependent Protein Kinases, Oxidative Stress, Rats, Glucagon-Like Peptide 1

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review