Free radicals and diabetes

Oberley, Larry W.

doi:10.1016/0891-5849(88)90036-6

Cited by 1,105Antioxidant Activity and Oxidative StressRedox biology and oxidative stressNitric Oxide and Endothelin Effects

Free radicals and diabetes

Oberley, Larry W.·1988·Free Radical Biology and Medicine

DOI 10.1016/0891-5849(88)90036-6

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Abstract

The role of active oxygen species in diabetes is discussed in this review. Type I diabetes is caused by destruction of the pancreatic beta cells responsible for producing insulin. In humans, the diabetogenic process appears to be caused by immune destruction of the beta cells; part of this process is apparently mediated by white cell production of active oxygen species. Diabetes can be produced in animals by the drugs alloxan and streptozotocin; the mechanism of action of these two drugs is different, but both result in the production of active oxygen species. Scavengers of oxygen radicals are effective in preventing diabetes in these animal models. Not only are oxygen radicals involved in the cause of diabetes, they also appear to play a role in some of the complications seen in long-term treatment of diabetes. Changes in antioxidants in the diabetic state and their consequences are discussed.

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Iron excess is a known feature of gestational diabetes and a clear risk factor for diabetes even in normal populations; diabetes is a classical consequence of iron overloading in hereditary haemochromatosis.
“Iron 'excess' is also a known feature of gestational diabetes [591-593], and is a clear risk factor for the disease even in 'normal' populations [594-603], and indeed diabetes is a classical consequence of iron overloading as seen in hereditary haemochromatosis [604].”
From Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases (2009) · cites this paper as [594]

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Authors: Oberley, L. W.
Affiliations: University of Iowa (US)
Corresponding author: Oberley, Larry W.
Venue: Free Radical Biology and Medicine
Publisher: Elsevier BV
Published: 1988-01
Volume: 5
Issue: 2
Pages: 113-124
ISSN: 0891-5849 (ISSN-L)
DOI: 10.1016/0891-5849(88)90036-6
OpenAlex: W2161849974
Cited by: 1,105
References: 111
Citations by year: 2026: 2 · 2025: 6 · 2024: 16 · 2023: 17 · 2022: 28 · 2021: 22 · 2020: 24 · 2019: 21 · 2018: 20 · 2017: 24 · 2016: 26 · 2015: 51 · 2014: 39 · 2013: 55 · 2012: 55
FWCI: 8.24
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Free Radical Biology and Medicine (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (2r01ca041267-04a3)
National Cancer Institute (R01 CA 41267)
Topics: Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Keywords: free radicals, reactive oxygen species, diabetes mellitus, type 1 diabetes, beta cell destruction, autoimmunity, alloxan, streptozotocin, oxygen radical scavengers, antioxidant status, diabetes complications
MeSH terms: Animals, Diabetes Mellitus, Diabetes Mellitus, Experimental, Free Radicals, Humans, Peroxidases

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