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GLP-1 promotes angiogenesis in human endothelial cells in a dose-dependent manner, through the Akt, Src and PKC pathways
Open accessAbstract
Introduction Novel anti-diabetic medications that mimic or augment the physiological actions of GLP-1 improve cardiovascular risk factors in diabetics and GLP-1 has been proposed to have a beneficial role in the cardiovascular system. GLP-1 may have a direct cardioprotective role by decreasing infarct size and protecting from ischemia-reperfusion injury while prolonging survival in rodent models. The mechanisms underlying these observations remain largely unknown. In vitro studies suggest that GLP-1 may promote endothelial cell proliferation, but no study to date has evaluated a potential direct effect of GLP-1 on angiogenesis.Specific aim To evaluate whether GLP-1 affects angiogenesis in humans and to elucidate underlying molecular mechanisms.Material and methods We utilized a 3D culture system where spherules of human umbilical vein endothelial cells (HUVECs) embedded in a collagen scaffold were treated with escalating doses of human recombinant GLP-1 (50-2000 nmol/L) and the formation of new vessels was observed and quantified. Signaling inhibitors were utilized to identify molecular pathways through which GLP-1 promotes angiogenesis.Results We demonstrate that GLP-1 promotes angiogenesis in a dose-dependent manner. The maximum effect on angiogenesis was observed at a GLP-1 dose of 500 nmol/L, while increased angiogenesis occurred in response to doses ranging from 200 nmol/L to 1000 nmol/L. Pre-treatment of the system with Akt inhibitor IV, Bisindolylmaleimide (PKC inhibitor) and src inhibitor I resulted in a significant decrease of the GLP-1 induced angiogenesis.Conclusions This is the first study to demonstrate that GLP-1 promotes angiogenesis in a HUVEC three dimensional in vitro model. This effect requires pharmacological doses and is mediated through the Akt, PKC and src pathways.
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“GLP-1RA-induced angiogenesis appears to be mediated through the PI3K/Akt, PKA, and Src pathways [68].”
From Protection against stroke with glucagon-like peptide-1 receptor agonists: a comprehensive review of potential mechanisms (2022) · cites this paper as [68]
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Cites
Role of angiogenesis in tumor growth and metastasis
Folkman, J. (2002) · Seminars in Oncology · doi:10.1016/s0093-7754(02)70065-1 · Cited by 2,904
Role of angiogenesis in tumor growth and metastasis
Folkman, J. (2002) · Seminars in Oncology · doi:10.1053/sonc.2002.37263 · Cited by 2,424
Nitric oxide synthase modulates angiogenesis in response to tissue ischemia.
Murohara, T., Asahara, T., Silver, M., Bauters, C., Masuda, H., Kalka, C., Kearney, M., Chen, D., Symes, J. F., Fishman, M. C., et al. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1560 · Cited by 1,186
Ban, K., Noyan-Ashraf, M. H., Hoefer, J., Bolz, S.-S., Drucker, D. J., & Husain, M. (2008) · Circulation · doi:10.1161/circulationaha.107.739938 · Cited by 1,057
Fukumura, D., Gohongi, T., Kadambi, A., Izumi, Y., Ang, J., Yun, C., Buerk, D. G., Huang, P. L., & Jain, R. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.041359198 · Cited by 1,027
Nikolaidis, L. A., Mankad, S., Sokos, G. G., Miske, G., Shah, A., Elahi, D., & Shannon, R. P. (2004) · Circulation · doi:10.1161/01.cir.0000120505.91348.58 · Cited by 901
Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability
Eliceiri, B. P., Paul, R., Schwartzberg, P. L., Hood, J. D., Leng, J., & Cheresh, D. A. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80221-x · Cited by 823
Klonoff, D. C., Buse, J. B., Nielsen, L. L., Guan, X., Bowlus, C. L., Holcombe, J. H., Wintle, M. E., & Maggs, D. G. (2008) · Current Medical Research and Opinion · doi:10.1185/030079908x253870 · Cited by 699
Nyström, T., Gutniak, M. K., Zhang, Q., Zhang, F., Holst, J. J., Ahrén, B., & Sjöholm, Å. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00237.2004 · Cited by 680
Sokos, G. G., Nikolaidis, L. A., Mankad, S. V., Elahi, D., & Shannon, R. P. (2006) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2006.08.211 · Cited by 654
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Nauck, M. A., Quast, D. R., Wefers, J., & Pfeiffer, A. F. H. (2021) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.14496 · Cited by 388
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Goldney, J., Sargeant, J. A., & Davies, M. J. (2023) · Diabetologia · doi:10.1007/s00125-023-05988-3 · Cited by 100
Gaborit, B., Julla, J.-B., Besbes, S., Proust, M., Vincentelli, C., Alos, B., Ancel, P., Alzaid, F., Garcia, R., Mailly, P., et al. (2020) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz069 · Cited by 95
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Simó, R., & Hernández, C. (2017) · Diabetes · doi:10.2337/db16-1364 · Cited by 86
Posadino, A. M., Giordo, R., Cossu, A., Nasrallah, G. K., Shaito, A. A., Abou-Saleh, H., Eid, A. H., & Pintus, G. (2019) · Biomolecules · doi:10.3390/biom9060209 · Cited by 82
Vergès, B., Aboyans, V., Angoulvant, D., Boutouyrie, P., Cariou, B., Hyafil, F., Mohammedi, K., & Amarenco, P. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01686-3 · Cited by 72
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Sáez, T., Salsoso, R., Leiva, A., Toledo, F., de Vos, P., Faas, M. M., & Sobrevía, L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.010 · Cited by 66
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Chai, W., Fu, Z., Aylor, K. W., Barrett, E. J., & Liu, Z. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00205.2016 · Cited by 51
Chade, A. (2017) · Hypertension · doi:10.1161/hypertensionaha.116.08319 · Cited by 48
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Subiabre, M., Silva, L., Villalobos-Labra, R., Toledo, F., Mario Paublo, M., López, M. A., Salsoso, R., Pardo, F., Leiva, A., & Sobrevía, L. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.07.022 · Cited by 43
Garczorz, W., Gallego-Colón, E., Kosowska, A., Kłych‐Ratuszny, A., Woźniak, M., Marcol, W., Niesner, K. J., & Francuz, T. (2017) · Cardiovascular Therapeutics · doi:10.1111/1755-5922.12317 · Cited by 43
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Zhang, H., Meng, J., Zhou, S., Liu, Y., Qu, D., Wang, L., Li, X., Wang, N., Luo, X., & Ma, X. (2015) · The AAPS Journal · doi:10.1208/s12248-015-9854-1 · Cited by 43
Shao, S., Zhang, X., Xu, Q., Pan, R., & Chen, Y. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108270 · Cited by 42
Lei, Y., Hu, L., Yang, G., Piao, L., Jin, M., & Cheng, X. W. (2017) · Circulation Journal · doi:10.1253/circj.cj-16-1326 · Cited by 42
Xu, M., Liu, L., Wu, M., Jiang, M., Shou, L., Wang, W., Wu, J., Zhang, Y., Gong, F.-R., Chen, K., et al. (2018) · Oncogenesis · doi:10.1038/s41389-018-0102-2 · Cited by 42
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Rodrigues, T., Borges, P. D. N., Mar, L. A., Marques, D., Albano, M. N., Eickhoff, H., Carrêlo, C., Almeida, B., Pires, S., Abrantes, A. M., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105198 · Cited by 41
Love, K. M., Liu, J., Regensteiner, J. G., Reusch, J. E. B., & Liu, Z. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13045 · Cited by 40
Li, P., Chen, D., Cui, Y., Zhang, W., Weng, J., Yu, L., Chen, L., Chen, Z., Su, H., Yu, S., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00765 · Cited by 40
Li, N., Zhao, Y., Yue, Y., Chen, L., Yao, Z., & Niu, W. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.07.095 · Cited by 37
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Yoshino, Y., Ishisaka, M., Tsujii, S., Shimazawa, M., & Hara, H. (2015) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2015.01.098 · Cited by 34
Liao, P.-Z., Yang, D., Liu, D., & Zheng, Y. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485820 · Cited by 36
Tate, M., Chong, A., Robinson, E., Green, B. D., & Grieve, D. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.12943 · Cited by 33
Yin, W., Jiang, Y., Xu, S., Wang, Z., Peng, L., Fang, Q., Deng, T., Zhao, W., Zhang, W., & Lou, J. (2018) · Journal of Diabetes Investigation · doi:10.1111/jdi.12956 · Cited by 32
Chen, Y., Zhang, X., He, J., Xie, Y., & Yang, Y. (2018) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2017.12.015 · Cited by 32
Lewis, J. E., Omenge, D. K., Patterson, A., Anwaegbu, O. S., Tabukum, N. N., Lewis, J. E., & Lee, W. (2025) · Diabetes and Vascular Disease Research · doi:10.1177/14791641251322909 · Cited by 33
Wang, F., Zhang, X., Zhang, J., Xu, Q., Yu, X., Xu, A., Yi, C., Bian, X., & Shao, S. (2024) · Medicinal Research Reviews · doi:10.1002/med.22020 · Cited by 31
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Chaudagar, K. K., & Mehta, A. A. (2014) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2013-0391 · Cited by 10
Chaudagar, K. K., & Mehta, A. A. (2014) · Clinical and Experimental Hypertension · doi:10.3109/10641963.2014.881842 · Cited by 10
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Li, T., Ling, Z., Xie, K., Wang, Y., Miao, Z., Ji, X., Li, J., Hou, W., Tang, Q., Yuan, X., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94801-5 · Cited by 9
Machida, A., Suzuki, K., Nakayama, T., Miyagi, S., Maekawa, Y., Murakami, R., Uematsu, M., Kitaoka, T., & Oishi, A. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.5.15 · Cited by 11
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Li, J., Zhang, Y., Sun, X., Guan, H., Wang, J., Zhao, S., Tian, C., Han, M., Ma, K., & Li, M. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1742296 · Cited by 6
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Lee, Y., Tukei, K. L., Fang, Y., Kuila, S., Liu, X., & Imoukhuede, P. I. (2025) · FASEB BioAdvances · doi:10.1096/fba.2025-00027 · Cited by 8
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Kolloli, A., Singh, P., & Subbian, S. (2018) · Springer eBooks · doi:10.1007/978-3-319-97367-8_3 · Cited by 5
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Lenasi, H. (2016) · InTech eBooks · doi:10.5772/64680 · Cited by 5
Drewa, J., Lazar-Juszczak, K., Adamowicz, J., & Juszczak, K. (2025) · Cancers · doi:10.3390/cancers17091576 · Cited by 5
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Muir, K. C., Stone, C. R., Harris, D. D., Kanuparthy, M., Broadwin, M., Hamze, J., Feng, J., & Sellke, F. W. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00828.2025 · Cited by 4
Kim, M. T., Lee, S., Goh, G. S.-H., & Riew, K. D. (2026) · Global Spine Journal · doi:10.1177/21925682261419753 · Cited by 5
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Gupta, N., Uwawah, T. D., Singh, K., Madan, H., Kumar, S., Midha, B., Soni, K., Singh, A., Bhogal, A., & Jain, A. (2024) · Cureus · doi:10.7759/cureus.64668 · Cited by 2
Kotb, S. M., Farid, M. M., Al-Karmalawy, A. A., Zahran, M. A. H., Mohamed, B. S., Gadallah, A.-N. A.-A., & El‐Aarag, B. (2025) · Fitoterapia · doi:10.1016/j.fitote.2025.106939 · Cited by 2
Hsu, J., Ho, B., Sayed, R., Patel, N. T. P., & Dardik, A. (2026) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2026.02.003 · Cited by 1
Lin, M.-P., Xue, B.-J., & Bai, X. (2026) · Journal of Cardiovascular Translational Research · doi:10.1007/s12265-026-10759-7 · Cited by 1
Mylavarapu, M., Obi, O. S., Abarca, Y. A., Fatima, H., Roshni, P., Huda, N. U., Lysak, Y., Gandapur, A., Vazquez, S. A. C., Siddiqui, M. A., et al. (2026) · World Journal of Cardiology · doi:10.4330/wjc.v18.i3.112189 · Cited by 1
Muir, K. C., Harris, D. D., Stone, C. R., Kanuparthy, M., Hamze, J., Feng, J., & Sellke, F. W. (2026) · Microvascular Research · doi:10.1016/j.mvr.2026.104956 · Cited by 1
Zeraatian, S., Aghdam, R. M., & Hossein, A. S. (2015) · Cardiovascular Pharmacology Open Access · doi:10.4172/2329-6607.1000159 · Cited by 1
The Skeletal Muscle Microvasculature and Its Effects on Metabolism
Kolka, C. M. (2016) · InTech eBooks · doi:10.5772/63535 · Cited by 8
Wu, J., Guo, P., He, T., & Cai, F. (2017) · Turkish Journal of Biochemistry · doi:10.1515/tjb-2017-0013
Kiaei, N., & Aghdam, R. M. (2020) · Research Square · doi:10.21203/rs.3.rs-102352/v1
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Chen, Y., Shao, S., Zhang, X., Xu, Q., & Pan, R. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4161722
Dao, M. Q., Kim, A. Y., Wang, S., Won, P., Laspro, M., Gillenwater, T. J., Yenikomshian, H. A., & Johnson, M. B. (2025) · Burns · doi:10.1016/j.burns.2025.107848
Zhao, Z., Yue, H., Xu, W., Gong, S., & Shao, S. (2026) · Journal of Diabetes Research · doi:10.1155/jdr/6683809
Metadata
- Authors
- Aronis, K. N., Chamberland, J. P., & Mantzoros, C. S.
- Affiliations
- Boston University (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Aronis, Konstantinos N.
- Venue
- Metabolism
- Publisher
- Elsevier BV
- Published
- 2013-09
- Volume
- 62
- Issue
- 9
- Pages
- 1279-1286
- ISSN
- 0026-0495 (ISSN-L)
- PMC
- PMC3755020
- OpenAlex
- W1989453119
- Cited by
- 104
- References
- 51
- Citations by year
- 2026: 13 · 2025: 13 · 2024: 11 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 4 · 2019: 5 · 2018: 10 · 2017: 13 · 2016: 9 · 2015: 6 · 2014: 8 · 2013: 1
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- U.S. Department of Veterans Affairs (I01 CX000422)
- National Institute on Aging (R01AG032030, AG032030.)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK079929, DK-081913, R01DK058785, R56DK058785, DK079929, DK058785, K24DK081913)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Keywords
- glucagon-like peptide-1, angiogenesis, human umbilical vein endothelial cells, Akt signaling, Src kinase, protein kinase C, dose-dependent effects, endothelial cell proliferation, cardioprotection, diabetes mellitus
- MeSH terms
- Cells, Cultured, Humans, Protein Kinase C, Neovascularization, Physiologic, src-Family Kinases, Endothelial Cells, Proto-Oncogene Proteins c-akt, Glucagon-Like Peptide 1, Human Umbilical Vein Endothelial Cells
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