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TCF7L2 rs7903146 polymorphism modulates the association between adherence to a Mediterranean diet and the risk of gestational diabetes mellitus

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Barabash, Ana, Valerio, Johanna D., Garcia de la Torre, Nuria, Jimenez, Inés, del Valle, Laura, Melero, Verónica, Assaf-Balut, Carla, Fuentes, Manuel +9 more·2020·Metabolism Open
DOI 10.1016/j.metop.2020.100069PMC PMC7718167
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Abstract

OBJECTIVE: There is sparse evidence for the impact of gene-diet interaction on gestational diabetes mellitus (GDM) onset. Recent findings have shown that late first-trimester high adherence to a Mediterranean diet (MedDiet) pattern is associated with a GDM risk reduction. The aim of this study was to investigate if this effect could be modulated by TCF7L2 rs7903146 polymorphism.Research design and methods: A total of 874 pregnant women participants in the St Carlos GDM prevention study, were stratified into three groups defined as "High,5-6 on targets", "Moderate, 2-4 on targets" or "Low, 0-1 on targets" adherence to Mediterranean diet according to late first-trimester compliance with six food targets: >12 servings/week of vegetables, >12 pieces/week of fruits, <2 servings/week of juice, >3 servings/week of nuts, >6 days/week and >40 mL/day consumption of extra virgin olive oil. All patients were genotyped for rs7903146 using Taqman technology. RESULTS: Logistic regression analysis revealed that the risk of developing GDM in those with high adherence versus low adherence was significantly reduced only in carriers of the T-allele (CT + TT), with an adjusted odds ratio of 0.15 (95% CI:0.05-0.48). This effect was not observed in CC carriers. Interaction analysis yielded significant rs7903146-MedDiet interaction in GDM risk (p < 0.03). CONCLUSIONS: Women carrying the rs7903146 T-allele who highly adhere to a MedDiet early in pregnancy have lower risk of developing GDM than CC carriers. This reinforces the importance of identifying patients at risk of GDM who would be especially sensitive to nutritional interventions based on their genetic characteristics.

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  • Carriers of the gene rs7903146 T-allele who followed the Mediterranean diet in early pregnancy had a lower risk of developing GDM.

    “A study conducted in Spain showed that carriers of the gene rs7903146 T-allele who followed the Mediterranean diet in early pregnancy had a lower risk of developing GDM [55].”

    From Gestational Diabetes Mellitus—Recent Literature Review (2022) · cites this paper as [55]

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  1. [1]Ruiz-Gracia T. Duran A. Fuentes M. Rubio M.A. Runkle I. Carrera E.F. Torrejon M.J. Bordiu E. Valle L.D. Garcia de la Torre N. Bedia A.R. Montanez C. Familiar C. Calle-Pascual A.L. Lifestyle patterns in early pregnancy linked to gestational diabetes mellitus diagnoses when using IADPSG criteria. The St Carlos gestational study Clin Nutr 35 2016 699 705 25998584
  2. [2]Assaf-Balut C. Garcia de la Torre N. Duran A. Fuentes M. Bordiu E. Del Valle L. Familiar C. Ortola A. Jimenez I. Herraiz M.A. Izquierdo N. Perez N. Torrejon M.J. Ortega M.I. Illana F.J. Runkle I. de Miguel M.P. Montanez C. Barabash A. Cuesta M. Rubio M.A. Calle-Pascual A.L. A Mediterranean diet with additional extra virgin olive oil and pistachios reduces the incidence of gestational diabetes mellitus (GDM): a randomized controlled trial: the St. Carlos GDM prevention study PloS One 12 2017 e0185873 PMC5648128 29049303
  3. [4]Assaf-Balut C. Garcia de la Torre N. Fuentes M. Duran A. Bordiu E. Del Valle L. Valerio J. Jimenez I. Herraiz M.A. Izquierdo N. Torrejon M.J. de Miguel M.P. Barabash A. Cuesta M. Rubio M.A. Calle-Pascual A.L. A high adherence to six food targets of the mediterranean diet in the late first trimester is associated with a reduction in the risk of materno-foetal outcomes: the st. Carlos gestational diabetes mellitus prevention study Nutrients 11 2018 PMC6356317 30602688
  4. [5]Grant S.F. Thorleifsson G. Reynisdottir I. Benediktsson R. Manolescu A. Sainz J. Helgason A. Stefansson H. Emilsson V. Helgadottir A. Styrkarsdottir U. Magnusson K.P. Walters G.B. Palsdottir E. Jonsdottir T. Gudmundsdottir T. Gylfason A. Saemundsdottir J. Wilensky R.L. Reilly M.P. Rader D.J. Bagger Y. Christiansen C. Gudnason V. Sigurdsson G. Thorsteinsdottir U. Gulcher J.R. Kong A. Stefansson K. Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 2006 320 323 16415884
  5. [6]Ding M. Chavarro J. Olsen S. Lin Y. Ley S.H. Bao W. Rawal S. Grunnet L.G. Thuesen A.C.B. Mills J.L. Yeung E. Hinkle S.N. Zhang W. Vaag A. Liu A. Hu F.B. Zhang C. Genetic variants of gestational diabetes mellitus: a study of 112 SNPs among 8722 women in two independent populations Diabetologia 61 2018 1758 1768 29947923 PMC6701842
  6. [7]Wu L. Cui L. Tam W.H. Ma R.C. Wang C.C. Genetic variants associated with gestational diabetes mellitus: a meta-analysis and subgroup analysis Sci Rep 6 2016 30539 27468700 PMC4965817
  7. [8]Lin P.C. Lin W.T. Yeh Y.H. Wung S.F. Transcription factor 7-like 2 (TCF7L2) rs7903146 polymorphism as a risk factor for gestational diabetes mellitus: a meta-analysis PloS One 11 2016 e0153044 PMC4825985 27058589
  8. [9]Jin T. Current understanding on role of the Wnt signaling pathway effector TCF7L2 in glucose homeostasis Endocr Rev 37 2016 254 277 27159876
  9. [10]Fisher E. Boeing H. Fritsche A. Doering F. Joost H.G. Schulze M.B. Whole-grain consumption and transcription factor-7-like 2 (TCF7L2) rs7903146: gene-diet interaction in modulating type 2 diabetes risk Br J Nutr 101 2009 478 481 19149908
  10. [11]Hindy G. Sonestedt E. Ericson U. Jing X.J. Zhou Y. Hansson O. Renstrom E. Wirfalt E. Orho-Melander M. Role of TCF7L2 risk variant and dietary fibre intake on incident type 2 diabetes Diabetologia 55 2012 2646 2654 22782288 PMC3433658
  11. [12]Corella D. Carrasco P. Sorli J.V. Estruch R. Rico-Sanz J. Martinez-Gonzalez M.A. Salas-Salvado J. Covas M.I. Coltell O. Aros F. Lapetra J. Serra-Majem L. Ruiz-Gutierrez V. Warnberg J. Fiol M. Pinto X. Ortega-Azorin C. Munoz M.A. Martinez J.A. Gomez-Gracia E. Gonzalez J.I. Ros E. Ordovas J.M. Mediterranean diet reduces the adverse effect of the TCF7L2-rs7903146 polymorphism on cardiovascular risk factors and stroke incidence: a randomized controlled trial in a high-cardiovascular-risk population Diabetes Care 36 2013 3803 3811 23942586 PMC3816851
  12. [13]Sole X. Guino E. Valls J. Iniesta R. Moreno V. SNPStats: a web tool for the analysis of association studies Bioinformatics 22 2006 1928 1929 16720584
  13. [14]Dietrich S. Jacobs S. Zheng J.S. Meidtner K. Schwingshackl L. Schulze M.B. Gene-lifestyle interaction on risk of type 2 diabetes: a systematic review Obes Rev 20 2019 1557 1571 31478326 PMC8650574
  14. [15]Wang B. Xue X. Investigations of associations between seven gene polymorphisms and gestational diabetes mellitus: evidence from a meta-analysis Gynecol Obstet Invest 2020 1 8 32248196
  15. [17]Franzago M. Fraticelli F. Nicolucci A. Celentano C. Liberati M. Stuppia L. Vitacolonna E. Molecular analysis of a genetic variants panel related to nutrients and metabolism: association with susceptibility to gestational diabetes and cardiometabolic risk in affected women J Diabetes Res 2017 2017 4612623 28133617 PMC5241477
  16. [18]Fritsche L. Sarief M. Wagner R. Stefan N. Lehmann R. Haring H.U. Grallert H. Fritsche A. Lechner A. Genetic variation in TCF7L2 rs7903146 and history of GDM negatively and independently impact on diabetes-associated metabolic traits Diabetes Res Clin Pract 146 2018 251 257 30419301
  17. [19]Vcelak J. Vejrazkova D. Vankova M. Lukasova P. Bradnova O. Halkova T. Bestak J. Andelova K. Kvasnickova H. Hoskovcova P. Vondra K. Vrbikova J. Bendlova B. T2D risk haplotypes of the TCF7L2 gene in the Czech population sample: the association with free fatty acids composition Physiol Res 61 2012 229 240 22480428
  18. [20]Pagan A. Sabater-Molina M. Olza J. Prieto-Sanchez M.T. Blanco-Carnero J.E. Parrilla J.J. Gil A. Larque E. A gene variant in the transcription factor 7-like 2 (TCF7L2) is associated with an increased risk of gestational diabetes mellitus Eur J Obstet Gynecol Reprod Biol 180 2014 77 82 25048152
  19. [21]Michalak-Wojnowska M. Gorczyca-Siudak D. Gorczyca T. Mosiewicz B. Kwasniewska A. Filip A. Mosiewicz J. Association between rs7901695 and rs7903146 polymorphisms of the TCF7L2 gene and gestational diabetes in the population of Southern Poland Ginekol Pol 87 2016 745 750 27958632
  20. [22]Popova P.V. Klyushina A.A. Vasilyeva L.B. Tkachuk A.S. Bolotko Y.A. Gerasimov A.S. Pustozerov E.A. Kravchuk E.N. Predeus A. Kostareva A.A. Grineva E.N. Effect of gene-lifestyle interaction on gestational diabetes risk Oncotarget 8 2017 112024 112035 29340108 PMC5762376
  21. [23]de Melo S.F. Frigeri H.R. dos Santos-Weiss I.C. Rea R.R. de Souza E.M. Alberton D. Gomes de Moraes Rego F. Picheth G. Polymorphisms in FTO and TCF7L2 genes of Euro-Brazilian women with gestational diabetes Clin Biochem 48 2015 1064 1067 26102344
  22. [24]Reyes-Lopez R. Perez-Luque E. Malacara J.M. Metabolic, hormonal characteristics and genetic variants of TCF7L2 associated with development of gestational diabetes mellitus in Mexican women Diabetes Metab Res Rev 30 2014 701 706 24639413
  23. [25]Klein K. Haslinger P. Bancher-Todesca D. Leipold H. Knofler M. Handisurya A. Kautzky-Willer A. Worda C. Transcription factor 7-like 2 gene polymorphisms and gestational diabetes mellitus J Matern Fetal Neonatal Med 25 2012 1783 1786 22524208
  24. [26]Grotenfelt N.E. Wasenius N.S. Rono K. Laivuori H. Stach-Lempinen B. Orho-Melander M. Schulz C.A. Kautiainen H. Koivusalo S.B. Eriksson J.G. Interaction between rs10830963 polymorphism in MTNR1B and lifestyle intervention on occurrence of gestational diabetes Diabetologia 59 2016 1655 1658 27209463
  25. [27]Li S.X. Imamura F. Ye Z. Schulze M.B. Zheng J. Ardanaz E. Arriola L. Boeing H. Dow C. Fagherazzi G. Franks P.W. Agudo A. Grioni S. Kaaks R. Katzke V.A. Key T.J. Khaw K.T. Mancini F.R. Navarro C. Nilsson P.M. Onland-Moret N.C. Overvad K. Palli D. Panico S. Quiros J.R. Rolandsson O. Sacerdote C. Sanchez M.J. Slimani N. Sluijs I. Spijkerman A.M. Tjonneland A. Tumino R. Sharp S.J. Riboli E. Langenberg C. Scott R.A. Forouhi N.G. Wareham N.J. Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct Am J Clin Nutr 106 2017 263 275 28592605 PMC5486199
  26. [28]Lopez-Ortiz M.M. Garay-Sevilla M.E. Tejero M.E. Perez-Luque E.L. Analysis of the interaction between transcription factor 7-like 2 genetic variants with nopal and wholegrain fibre intake: effects on anthropometric and metabolic characteristics in type 2 diabetes patients Br J Nutr 116 2016 969 978 27480250
  27. [29]InterAct C. Investigation of gene-diet interactions in the incretin system and risk of type 2 diabetes: the EPIC-InterAct study Diabetologia 59 2016 2613 2621 27623947 PMC6518069
  28. [30]Florez J.C. Jablonski K.A. Bayley N. Pollin T.I. de Bakker P.I. Shuldiner A.R. Knowler W.C. Nathan D.M. Altshuler D. Diabetes Prevention Program Research G. TCF7L2 polymorphisms and progression to diabetes in the Diabetes Prevention Program N Engl J Med 355 2006 241 250 16855264 PMC1762036
  29. [31]Faerch K. Pilgaard K. Knop F.K. Hansen T. Pedersen O. Jorgensen T. Holst J.J. Incretin and pancreatic hormone secretion in Caucasian non-diabetic carriers of the TCF7L2 rs7903146 risk T allele Diabetes Obes Metabol 15 2013 91 95 22862926
  30. [32]Jurado-Ruiz E. Alvarez-Amor L. Varela L.M. Berna G. Parra-Camacho M.S. Oliveras-Lopez M.J. Martinez-Force E. Rojas A. Hmadcha A. Soria B. Martin F. Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice Sci Rep 9 2019 11311 31383924 PMC6683141
  31. [33]Grau K. Cauchi S. Holst C. Astrup A. Martinez J.A. Saris W.H. Blaak E.E. Oppert J.M. Arner P. Rossner S. Macdonald I.A. Klimcakova E. Langin D. Pedersen O. Froguel P. Sorensen T.I. TCF7L2 rs7903146-macronutrient interaction in obese individuals’ responses to a 10-wk randomized hypoenergetic diet Am J Clin Nutr 91 2010 472 479 20032493
  32. [34]Roswall N. Angquist L. Ahluwalia T.S. Romaguera D. Larsen S.C. Ostergaard J.N. Halkjaer J. Vimaleswaran K.S. Wareham N.J. Bendinelli B. Palli D. Boer J.M. van der A.D. Boeing H. Loos R.J. Sorensen T.I. Tjonneland A. Association between Mediterranean and Nordic diet scores and changes in weight and waist circumference: influence of FTO and TCF7L2 loci Am J Clin Nutr 100 2014 1188 1197 25099543
  33. [35]Sotos-Prieto M. Smith C.E. Lai C.Q. Tucker K.L. Ordovas J.M. Mattei J. Mediterranean diet adherence modulates anthropometric measures by TCF7L2 genotypes among Puerto Rican adults J Nutr 150 2020 167 175 31504696 PMC6946896
  34. [36]Cauchi S. Choquet H. Gutierrez-Aguilar R. Capel F. Grau K. Proenca C. Dina C. Duval A. Balkau B. Marre M. Potoczna N. Langin D. Horber F. Sorensen T.I. Charpentier G. Meyre D. Froguel P. Effects of TCF7L2 polymorphisms on obesity in European populations Obesity 16 2008 476 482 18239663
  35. [37]Corella D. Coltell O. Sorli J.V. Estruch R. Quiles L. Martinez-Gonzalez M.A. Salas-Salvado J. Castaner O. Aros F. Ortega-Calvo M. Serra-Majem L. Gomez-Gracia E. Portoles O. Fiol M. Diez Espino J. Basora J. Fito M. Ros E. Ordovas J.M. Polymorphism of the transcription factor 7-like 2 gene (TCF7L2) interacts with obesity on type-2 diabetes in the PREDIMED study emphasizing the heterogeneity of genetic variants in type-2 diabetes risk prediction: time for obesity-specific genetic risk scores Nutrients 8 2016 PMC5188448 27929407
  36. [38]Nasreddine L. Akika R. Mailhac A. Tamim H. Zgheib N.K. The interaction between genetic polymorphisms in FTO and TCF7L2 genes and dietary intake with regard to body mass and composition: an exploratory study J Personalized Med 9 2019 PMC6463113 30764585
  37. [39]Haupt A. Thamer C. Heni M. Ketterer C. Machann J. Schick F. Machicao F. Stefan N. Claussen C.D. Haring H.U. Fritsche A. Staiger H. Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes Diabetes 59 2010 747 750 20028944 PMC2828665
  38. [40]Fisher E. Meidtner K. Angquist L. Holst C. Hansen R.D. Halkjaer J. Masala G. Ostergaard J.N. Overvad K. Palli D. Vimaleswaran K.S. Tjonneland A. van der A.D. Wareham N.J. Sorensen T. Loos R.J. Boeing H. Influence of dietary protein intake and glycemic index on the association between TCF7L2 HapA and weight gain Am J Clin Nutr 95 2012 1468 1476 22552033

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Authors
Barabash, A., Valerio, J. D., Garcia de la Torre, N., Jimenez, I., del Valle, L., Melero, V., Assaf-Balut, C., Fuentes, M., Bordiu, E., Durán, A., Herraiz, M. A., Izquierdo, N., Torrejón, M. J., de Miguel, P., Runkle, I., Rubio, M. A., & Calle-Pascual, A. L.
Affiliations
  • Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas (ES)
  • Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (ES)
  • Hospital Clínico San Carlos (ES)
  • Universidad Complutense de Madrid (ES)
ORCID
Venue
Metabolism Open
Publisher
Elsevier BV
Published
2020-12
Volume
8
Pages
100069
ISSN
2589-9368 (ISSN-L)
DOI
10.1016/j.metop.2020.100069
PMC
PMC7718167
OpenAlex
W3107239958
Cited by
18
References
2
Citations by year
2025: 3 · 2024: 5 · 2023: 3 · 2022: 7
FWCI
1.53
Type
journal article
Language
en
Open access
Licence
Locations
  • Metabolism Open (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Instituto de Salud Carlos III
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Nutrition, Genetics, and Disease
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords
TCF7L2, rs7903146, Mediterranean diet, gestational diabetes mellitus, gene-diet interaction, dietary adherence, first trimester, genetic susceptibility, extra virgin olive oil, dietary intervention, pregnancy

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