Cited by 72Gestational Diabetes Research and ManagementGenetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Genetic Determinants for Gestational Diabetes Mellitus and Related Metabolic Traits in Mexican Women

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Huerta-Chagoya, Alicia, Vázquez-Cárdenas, Paola, Moreno-Macías, Hortensia, Tapia-Maruri, Leonardo, Rodríguez-Guillén, Rosario, López-Vite, Erika, García-Escalante, Guadalupe, Escobedo-Aguirre, Fernando +7 more·2015·PLOS ONE

Abstract

Epidemiological and physiological similarities among Gestational Diabetes Mellitus (GDM) and Type 2 Diabetes (T2D) suggest that both diseases, share a common genetic background. T2D risk variants have been associated to GDM susceptibility. However, the genetic architecture of GDM is not yet completely understood. We analyzed 176 SNPs for 115 loci previously associated to T2D, GDM and body mass index (BMI), as well as a set of 118 Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women. Association with GDM was found for two of the most frequently replicated T2D loci: a TCF7L2 haplotype (CTTC: rs7901695, rs4506565, rs7903146, rs12243326; P=2.16 x 10(-06); OR=2.95) and a KCNQ1 haplotype (TTT: rs2237892, rs163184, rs2237897; P=1.98 x 10(-05); OR=0.55). In addition, we found two loci associated to glycemic traits: CENTD2 (60' OGTT glycemia: rs1552224, P=0.03727) and MTNR1B (HOMA B: rs1387153, P=0.05358). Remarkably, a major susceptibility SLC16A11 locus for T2D in Mexicans was not shown to play a role in GDM risk. The fact that two of the main T2D associated loci also contribute to the risk of developing GDM in Mexicans, confirm that both diseases share a common genetic background. However, lack of association with a Native American contribution T2D risk haplotype, SLC16A11, suggests that other genetic mechanisms may be in play for GDM.

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  • A growing trend of gestational diabetes mellitus prevalence has been observed in Mexico.

    “A growing trend of GDM prevalence has been observed [56,57,58,59,60,61].”

    From Evolution of Gestational Diabetes Mellitus across Continents in 21st Century (2022) · cites this paper as [61]

    The Introduction reports one Mexican GDM prevalence estimate, 12.9%, and says no nationwide prevalence has been reported. The Results describe a case-control sample, not prevalence over time. Searches for an increasing prevalence or temporal trend found no passage establishing that GDM prevalence has grown in Mexico. (LLM, conf=0.75)

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Research works printed but not linked: 1

  1. [3]Jimenez-Corona AA-S, Rojas-Martínez R, Hernandez-Avila M. Diaberes Mellitus tipo 2 y frecuencia de acciones. Salud Publica Mex. 2013; 3(35): S137– S42. 24626689

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Authors
Huerta-Chagoya, A., Vázquez-Cárdenas, P., Moreno-Macías, H., Tapia-Maruri, L., Rodríguez-Guillén, R., López-Vite, E., García-Escalante, G., Escobedo-Aguirre, F., Parra-Covarrubias, A., Cordero-Brieño, R., Manzo-Carrillo, L., Zacarías-Castillo, R., Vargas-García, C., Aguilar-Salinas, C., & Tusié-Luna, T.
Affiliations
  • Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
  • Universidad Autónoma Metropolitana (MX)
  • Instituto Nacional de Perinatología (MX)
  • Hospital General Dr. Manuel Gea Gonzalez (MX)
Venue
PLOS ONE
Published
2015-05-14
Volume
10
Issue
5
Pages
e0126408
ISSN
1932-6203 (ISSN-L)
OpenAlex
W340488163
Cited by
72
References
85
Citations by year
2026: 2 · 2025: 3 · 2024: 11 · 2023: 5 · 2022: 12 · 2021: 7 · 2020: 7 · 2019: 8 · 2018: 2 · 2017: 9 · 2016: 6
FWCI
6.45
Type
journal article
Language
en
Open access
Locations
  • PLoS ONE (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • Figshare (submittedVersion, cc-by)
  • Greater South Information System
Funders
  • Consejo Nacional de Ciencia y Tecnología
  • Instituto Carlos Slim de la Salud
Topics
  • Health Sciences › Medicine › Obstetrics and Gynecology › Gestational Diabetes Research and Management
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
Keywords
gestational diabetes mellitus, type 2 diabetes, genetic susceptibility, TCF7L2, KCNQ1, MTNR1B, ancestry informative markers, Mexican women, glycemic traits, body mass index, Native American ancestry
MeSH terms
Adult, Carrier Proteins, Diabetes Mellitus, Type 2, Female, Humans, Mexico, Pregnancy, Diabetes, Gestational, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, GTPase-Activating Proteins, Monocarboxylic Acid Transporters, Receptor, Melatonin, MT2, KCNQ1 Potassium Channel, Young Adult, Genetic Association Studies, Transcription Factor 7-Like 2 Protein

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