A yeast by any other name: Candida glabrata and its interaction with the host
Abstract
Well-characterized traits important to Candida albicans virulence, such as hyphal formation or secreted proteinase activity, play no known role in Candida glabrata virulence. Likewise, some C. glabrata characteristics, such as chromatin-based regulation of the large telomeric family of lectins encoded by the EPA (epithelial adhesin) genes, have no precise parallels in C. albicans. However, similarities between the two species, for example in population structure, in the large numbers of (putative) adhesins that they encode, and in phenotypic plasticity conferred by phenotypic switching, suggest that they share general strategies in adaptation to an opportunistic lifestyle.
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C. glabrata, S. cerevisiae, C. albicans, and C. neoformans show replicative ageing, a process where mother cells progressively age, producing asymmetric mitotic divisions resulting in phenotypically distinct daughter cells.
“Candida glabrata as occur in S. cerevisiae, C. albicans, and C. neoformans show a replicative ageing, a process where original mother cells progressively age, producing asymmetric mitotic divisions resulting in phenotypically distinct daughter cells [16].”
From Candida glabrata: pathogenicity and resistance mechanisms for adaptation and survival (2021) · cites this paper as [16]
Secreted aspartyl proteases are key fungal virulence factors.
“Secreted aspartyl proteases are key fungal virulence factors [28].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [28]
The Epa sub-family I contains the PA14 ligand-binding domain, is most well studied, and consists of 17 to 23 proteins depending upon the isolate.
“The Epa (Epithelial Adhesin) sub-family I, containing the PA14 (Anthrax Protective Antigen) ligand-binding domain, is most well studied, and consists of 17 to 23 proteins depending upon the isolate [27,28].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [28]
The sequenced fecal isolate CBS 138 contains 17 Epa-encoding genes, while the vaginal isolate BG2 contains 23 Epa-encoding genes.
“The sequenced fecal isolate CBS 138 contains 17 Epa-encoding genes, while the widely used vaginal isolate BG2 contains 23 Epa-encoding genes [27,28].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [28]
Morphological switching from the yeast to the hyphal form has not been reported in C. glabrata.
“Importantly, morphological switching from the yeast to the hyphal form has not been reported [28], although C. glabrata displayed pseudohyphal structures in response to nitrogen starvation and carbon dioxide exposure [70,71].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [28]
C. glabrata can assimilate both glucose and trehalose, but lacks genes for assimilation of galactose and sucrose.
“C. glabrata can assimilate both glucose and trehalose, but lacks genes for assimilation of galactose and sucrose [17,28].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [28]
C. glabrata lacks genes involved in thiamine, pyridoxine and nicotinic acid biosynthetic pathways.
“C. glabrata also lacks genes involved in thiamine, pyridoxine and nicotinic acid biosynthetic pathways [28].”
From Candida glabrata: A Lot More Than Meets the Eye (2019) · cites this paper as [28]
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References 60 · Cited by 271
- Authors
- Kaur, R., Domergue, R., Zupancic, M. L., & Cormack, B. P.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Cormack, Brendan P
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2005-08
- Volume
- 8
- Issue
- 4
- Pages
- 378-384
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2022006512
- Semantic Scholar
- 897cae7080dbe58ae89f898e0b882014bb4738c6
- Cited by
- 271
- References
- 60
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 9 · 2023: 5 · 2022: 9 · 2021: 13 · 2020: 9 · 2019: 10 · 2018: 16 · 2017: 13 · 2016: 14 · 2015: 26 · 2014: 13 · 2013: 22 · 2012: 21
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
- Keywords
- Candida glabrata, Candida albicans, fungal virulence, host-pathogen interaction, chromatin regulation, adhesins, phenotypic switching, phenotypic plasticity, opportunistic pathogens, fungal population structure
- MeSH terms
- Candidiasis, Cell Adhesion, Fungal Proteins, Humans, Virulence, Gene Expression Regulation, Fungal, Candida glabrata
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