β-Lactam antibiotic resistance: a current structural perspective
Abstract
Bacterial resistance to beta-lactam antibiotics can be achieved by any of three strategies: the production of beta-lactam-hydrolyzing beta-lactamase enzymes, the utilization of beta-lactam-insensitive cell wall transpeptidases, and the active expulsion of beta-lactam molecules from Gram-negative cells by way of efflux pumps. In recent years, structural biology has contributed significantly to the understanding of these processes and should prove invaluable in the design of drugs to combat beta-lactam resistance in the future.
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Bacteria can resist β-lactam antibiotics by producing β-lactamase, which cleaves the β-lactam ring.
“One of the strategies deployed by this group of bacteria to survive against β-lactam antibiotics is by the production of a β-lactam-hydrolyzing enzyme – β-lactamase; which functions to neutralize these antibiotics by cleaving the β-lactam ring (Wilke et al., 2005; Toussaint and Gallagher, 2015).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Wilke et al., 2005
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References 46 · Cited by 383
- Authors
- Wilke, M. S., Lovering, A. L., & Strynadka, N. C.
- Affiliations
- University of British Columbia (CA)
- Corresponding author
- Strynadka, Natalie CJ
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2005-10
- Volume
- 8
- Issue
- 5
- Pages
- 525-533
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W1963606386
- Cited by
- 383
- References
- 46
- Citations by year
- 2026: 15 · 2025: 26 · 2024: 17 · 2023: 15 · 2022: 15 · 2021: 26 · 2020: 21 · 2019: 22 · 2018: 19 · 2017: 21 · 2016: 28 · 2015: 24 · 2014: 19 · 2013: 19 · 2012: 21
- FWCI
- 0.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Antibiotic Resistance in Bacteria
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Keywords
- beta-lactam antibiotics, antibiotic resistance, beta-lactamase, efflux pumps, Gram-negative bacteria, structural biology, drug design
- MeSH terms
- Anti-Bacterial Agents, Bacteria, beta-Lactamases, Biological Transport, Active, Models, Molecular, Drug Design, Molecular Structure, beta-Lactam Resistance, Penicillin-Binding Proteins, beta-Lactams
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