Cited by 676Bacterial Genetics and BiotechnologyMicrobial Metabolic Engineering and BioproductionBiochemical and Molecular Research

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The mechanisms of carbon catabolite repression in bacteria

Deutscher, Josef·2008·Current Opinion in Microbiology

DOI 10.1016/j.mib.2008.02.007

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Abstract

Carbon catabolite repression (CCR) is the paradigm of cellular regulation. CCR happens when bacteria are exposed to two or more carbon sources and one of them is preferentially utilised (frequently glucose). CCR is often mediated by several mechanisms, which can either affect the synthesis of catabolic enzymes via global or specific regulators or inhibit the uptake of a carbon source and thus the formation of the corresponding inducer. The major CCR mechanisms operative in Enterobacteriaceae and Firmicutes are quite different, but in both types of organisms components of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) and protein phosphorylation play a major role. PTS-independent CCR mechanisms are operative in several other bacteria.

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Authors: Deutscher, J.
Affiliations: Centre National de la Recherche Scientifique (FR)
Corresponding author: Deutscher, Josef
ORCID: Deutscher, Josef
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2008-04
Volume: 11
Issue: 2
Pages: 87-93
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2008.02.007
OpenAlex: W2038683612
Cited by: 676
References: 52
Citations by year: 2026: 30 · 2025: 32 · 2024: 28 · 2023: 32 · 2022: 37 · 2021: 48 · 2020: 45 · 2019: 38 · 2018: 47 · 2017: 46 · 2016: 28 · 2015: 40 · 2014: 33 · 2013: 43 · 2012: 48
FWCI: 3.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: Fonds De La Recherche Scientifique - FNRS
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Molecular Research
Keywords: catabolite repression, glucose repression, phosphoenolpyruvate:carbohydrate phosphotransferase system, protein phosphorylation, Enterobacteriaceae, Firmicutes
MeSH terms: Bacteria, Bacterial Proteins, Carbon, Enterobacteriaceae, Phosphoenolpyruvate Sugar Phosphotransferase System, Transcription, Genetic, Signal Transduction, Gene Expression Regulation, Bacterial

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The mechanisms of carbon catabolite repression in bacteria

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