Carbon catabolite repression in bacteria: many ways to make the most out of nutrients
Abstract
Most bacteria can selectively use substrates from a mixture of different carbon sources. The presence of preferred carbon sources prevents the expression, and often also the activity, of catabolic systems that enable the use of secondary substrates. This regulation, called carbon catabolite repression (CCR), can be achieved by different regulatory mechanisms, including transcription activation and repression and control of translation by an RNA-binding protein, in different bacteria. Moreover, CCR regulates the expression of virulence factors in many pathogenic bacteria. In this Review, we discuss the most recent findings on the different mechanisms that have evolved to allow bacteria to use carbon sources in a hierarchical manner.
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Oils could act as an antifoam, preventing formation of foam in the media that may impede gas exchange and negatively affect bacteria growth.
“Other than preventing carbon catabolite regulation, these oils could act as an antifoam, preventing the formation of foam in the media that may impede gas exchange and negatively affect bacteria growth (Friberg et al., 1989; Görke and Stülke, 2008).”
From Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review (2016) · cites this paper as Görke and Stülke, 2008
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“Proteins from each of these families play a role in carbon catabolite repression, a process known to be regulated by the presence or absence of environmental carbon sources [26,27,28].”
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- Authors
- Görke, B., & Stülke, J.
- Affiliations
- University of Göttingen (DE)
- Corresponding author
- Stülke, Jörg
- Venue
- Nature Reviews Microbiology
- Published
- 2008-08
- Volume
- 6
- Issue
- 8
- Pages
- 613-624
- ISSN
- 1740-1526 (ISSN-L)
- 1740-1534
- OpenAlex
- W2036449301
- Cited by
- 1,701
- References
- 3
- Citations by year
- 2026: 111 · 2025: 125 · 2024: 83 · 2023: 95 · 2022: 100 · 2021: 126 · 2020: 106 · 2019: 100 · 2018: 100 · 2017: 99 · 2016: 96 · 2015: 122 · 2014: 89 · 2013: 86 · 2012: 72
- FWCI
- 5.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- catabolite repression, bacterial carbon source utilization, carbon source preference, transcriptional regulation, translational regulation, RNA-binding proteins, virulence regulation, pathogenic bacteria, catabolic gene expression, bacterial growth
- MeSH terms
- Bacteria, Bacterial Proteins, Carbon, Enzyme Repression, Transcription, Genetic, Gene Expression Regulation, Bacterial
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