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Cited by 477Bacteriophages and microbial interactionsAntimicrobial agents and applicationsBacterial Genetics and Biotechnology

Bacteriophage lysins as effective antibacterials

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Fischetti, Vincent A·2008·Current Opinion in Microbiology
DOI 10.1016/j.mib.2008.09.012PMC PMC2597892
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Abstract

Lysins are highly evolved enzymes produced by bacteriophage (phage for short) to digest the bacterial cell wall for phage progeny release. In Gram-positive bacteria, small quantities of purified recombinant lysin added externally results in immediate lysis causing log-fold death of the target bacterium. Lysins have been used successfully in a variety of animal models to control pathogenic antibiotic resistant bacteria found on mucosal surfaces and infected tissues. The advantages over antibiotics are their specificity for the pathogen without disturbing the normal flora, the low chance of bacterial resistance to lysins, and their ability to kill colonizing pathogens on mucosal surfaces, a capacity previously unavailable. Thus, lysins may be a much needed anti-infective in an age of mounting antibiotic resistance.

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  • Banana residue has higher phenolic content than avocado, pineapple, papaya, passion fruit, watermelon and melon.

    “Banana residue has high phenolic content than avocado, pineapple, papaya, passion fruit, watermelon and melon [23].”

    From Functional, nutritional and medicinal potential of banana peel (2023) · cites this paper as [23]

    The Structure and Antibiotic and Lysin Synergy sections discuss bacteriophage lysins, not fruit residues or phenolic content; page numbers are unavailable in our copy. Searches for banana residue, the named comparison fruits, and fruit-waste phenolics found no passage addressing the claim. (LLM, conf=0.78)

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Authors
Fischetti, V. A.
Affiliations
Rockefeller University (US)
Corresponding author
Fischetti, Vincent A
ORCID
Fischetti, Vincent A
Venue
Current Opinion in Microbiology
Publisher
Elsevier BV
Published
2008-10
Volume
11
Issue
5
Pages
393-400
ISSN
1369-5274 (ISSN-L)
DOI
10.1016/j.mib.2008.09.012
PMC
PMC2597892
OpenAlex
W2063524891
Cited by
477
References
0
Citations by year
2026: 25 · 2025: 32 · 2024: 26 · 2023: 31 · 2022: 30 · 2021: 32 · 2020: 23 · 2019: 26 · 2018: 25 · 2017: 24 · 2016: 20 · 2015: 42 · 2014: 23 · 2013: 31 · 2012: 30
FWCI
1.79
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Current Opinion in Microbiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI057472, AI-11822, AI 057472, R01AI011822, R37AI011822)
Topics
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
  • Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords
bacteriophage lysin, antibacterial agents, Gram-positive bacteria, antibiotic resistance, mucosal infection, phage therapy, pathogen specificity
MeSH terms
Animals, Anti-Bacterial Agents, Bacterial Infections, Bacteriolysis, Bacteriophages, Drug Resistance, Microbial, Gram-Positive Bacteria, Humans, Viral Proteins, Microbial Viability

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