The DOI matches its Crossref record; 71 of the 71 references it cites were found in a registry or an index.
Role of reactive oxygen species in antibiotic action and resistance
Open accessAbstract
The alarming spread of bacterial strains exhibiting resistance to current antibiotic therapies necessitates that we elucidate the specific genetic and biochemical responses underlying drug-mediated cell killing, so as to increase the efficacy of available treatments and develop new antibacterials. Recent research aimed at identifying such cellular contributions has revealed that antibiotics induce changes in metabolism that promote the formation of reactive oxygen species, which play a role in cell death. Here we discuss the relationship between drug-induced oxidative stress, the SOS response and their potential combined contribution to resistance development. Additionally, we describe ways in which these responses are being taken advantage of to combat bacterial infections and arrest the rise of resistant strains.
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Cites
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A Common Mechanism of Cellular Death Induced by Bactericidal Antibiotics
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Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli
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Toxic DNA damage by hydrogen peroxide through the Fenton reaction in vivo and in vitro
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The antibiotic resistome: the nexus of chemical and genetic diversity
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Cited by
Graves, D. B. (2012) · Journal of Physics D: Applied Physics · doi:10.1088/0022-3727/45/26/263001 · Cited by 1,518
Rudrapal, M., Khairnar, S. J., Khan, J., Dukhyil, A. B., Ansari, M. A., Alomary, M. N., Alshabrmi, F. M., Palai, S., Deb, P. K., & Devi, R. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.806470 · Cited by 1,084
Sublethal Antibiotic Treatment Leads to Multidrug Resistance via Radical-Induced Mutagenesis
Kohanski, M. A., DePristo, M. A., & Collins, J. J. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.003 · Cited by 985
Self-citationBiofilm-Specific Antibiotic Resistance
Mah, T.-F. (2012) · Future Microbiology · doi:10.2217/fmb.12.76 · Cited by 504
Kell, D. B. (2010) · Archives of Toxicology · doi:10.1007/s00204-010-0577-x · Cited by 361
Metadata
- Authors
- Dwyer, D. J., Kohanski, M. A., & Collins, J. J.
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2009-10
- Volume
- 12
- Issue
- 5
- Pages
- 482-489
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2038779898
- Cited by
- 484
- References
- 71
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- green
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- Dwyer, D. J., Kohanski, M. A., & Collins, J. J. (2009). Role of reactive oxygen species in antibiotic action and resistance. Current Opinion in Microbiology. https://doi.org/10.1016/j.mib.2009.06.018
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
