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Biofilm-Specific Antibiotic Resistance

Mah, Thien-Fah·2012·Future Microbiology
DOI 10.2217/fmb.12.76
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Abstract

Bacterial biofilms are the basis of many persistent diseases. The persistence of these infections is primarily attributed to the increased antibiotic resistance exhibited by the cells within the biofilms. This resistance is multifactorial; there are multiple mechanisms of resistance that act together in order to provide an increased overall level of resistance to the biofilm. These mechanisms are based on the function of wild-type genes and are not the result of mutations. This article reviews the known mechanisms of resistance, including the ability of the biofilm matrix to prevent antibiotics from reaching the cells and the function of individual genes that are preferentially expressed in biofilms. Evidence suggests that these mechanisms have been developed as a general stress response of biofilms that enables the cells in the biofilm to respond to all of the changes in the environment that they may encounter.

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Research works printed but not linked: 103

  1. 10.1146/annurev.mi.49.100195.003431 · DOI
  2. 10.1038/nrmicro1838 · DOI · Paper page
  3. 10.1128/JB.183.22.6579-6589.2001 · DOI
  4. 10.1128/JB.181.19.5993-6002.1999 · DOI
  5. 10.1186/1471-2164-7-162 · DOI
  6. 10.1128/JB.187.18.6571-6576.2005 · DOI
  7. 10.1007/978-3-0348-7139-6_2 · DOI
  8. 10.1128/JCM.43.10.5085-5090.2005 · DOI
  9. 10.1111/j.1574-6968.2006.00547.x · DOI
  10. 10.1128/AEM.69.4.2313-2320.2003 · DOI
  11. 10.1128/JCM.37.6.1771-1776.1999 · DOI · Paper page
  12. 10.1016/S0140-6736(01)05321-1 · DOI
  13. 10.1016/S0966-842X(00)01913-2 · DOI · Paper page
  14. 10.1146/annurev.micro.54.1.49 · DOI · Paper page
  15. 10.1016/j.cell.2007.03.004 · DOI
  16. 10.1007/978-3-540-75418-3_6 · DOI
  17. 10.1146/annurev.micro.57.030502.090720 · DOI
  18. 10.1111/j.1574-695X.2010.00690.x · DOI
  19. 10.1002/ppul.21011 · DOI
  20. 10.1038/35037627 · DOI
  21. 10.1007/s12016-008-8079-9 · DOI
  22. 10.1097/MOP.0b013e3280123a5d · DOI
  23. 10.1371/journal.pone.0022702 · DOI
  24. 10.1073/pnas.0804326105 · DOI
  25. 10.4161/viru.19763 · DOI
  26. 10.1126/science.1084550 · DOI
  27. 10.1016/j.tim.2004.07.005 · DOI
  28. 10.1016/j.micinf.2004.05.023 · DOI
  29. 10.1128/IAI.70.12.7042-7049.2002 · DOI
  30. 10.1128/AAC.00014-10 · DOI
  31. 10.4161/viru.2.5.17724 · DOI
  32. 10.1038/nrmicro2182 · DOI
  33. 10.1016/j.ijmm.2006.01.042 · DOI
  34. 10.1128/JB.186.6.1838-1850.2004 · DOI
  35. 10.1128/JB.187.1.37-44.2005 · DOI
  36. 10.1099/mic.0.2006/004911-0 · DOI
  37. 10.1128/JB.185.15.4585-4592.2003 · DOI
  38. 10.1111/j.1365-2958.2009.06934.x · DOI
  39. 10.1128/AEM.00710-08 · DOI
  40. 10.1128/JB.00022-12 · DOI
  41. 10.1126/science.295.5559.1487 · DOI · Paper page
  42. 10.1111/j.1574-6976.2011.00322.x · DOI
  43. 10.1128/AAC.47.1.317-323.2003 · DOI
  44. 10.1128/AAC.38.9.2125 · DOI
  45. 10.1128/AEM.00637-11 · DOI
  46. Khan W , BernierSP, KuchmaSL, HammondJH, HasanF, O‘TooleGA. Aminoglycoside resistance of Pseudomonas aeruginosa biofilms modulated by extracellular polysaccharide. Int. Microbiol.13(4) , 207–212 (2010).
  47. 10.1371/journal.ppat.1001264 · DOI
  48. 10.1073/pnas.1231792100 · DOI
  49. 10.1128/JB.183.18.5395-5401.2001 · DOI
  50. 10.4049/jimmunol.175.11.7512 · DOI
  51. 10.1007/978-3-540-75418-3_10 · DOI
  52. 10.1016/j.tim.2005.01.003 · DOI
  53. 10.1371/journal.ppat.0030057 · DOI
  54. 10.1111/j.1365-2958.2005.05008.x · DOI
  55. 10.1371/journal.ppat.1000213 · DOI
  56. 10.1371/journal.pone.0029276 · DOI
  57. 10.1099/jmm.0.05069-0 · DOI · Paper page
  58. 10.1128/JB.00119-09 · DOI
  59. 10.1186/1471-2180-6-53 · DOI
  60. 10.1038/nrmicro1147 · DOI
  61. 10.1128/AEM.05068-11 · DOI
  62. 10.1046/j.1365-2958.2003.03512.x · DOI
  63. 10.1128/AAC.00043-09 · DOI
  64. 10.1016/j.bbrc.2011.08.063 · DOI
  65. 10.1016/j.cell.2007.06.049 · DOI · Paper page
  66. 10.1016/j.mib.2009.06.018 · DOI
  67. 10.1038/nature02122 · DOI
  68. 10.1128/JB.01655-07 · DOI
  69. 10.1128/JB.00268-11 · DOI
  70. 10.1128/jb.178.15.4635-4642.1996 · DOI
  71. Bhagwat AA , TullyRE, KeisterDL. Identification and cloning of a cyclic beta-(1-->3), beta-(1-->6)-D-glucan synthesis locus from Bradyrhizobium japonicum.FEMS Microbiol. Lett.114(2) , 139–144. (1993).
  72. 10.1093/glycob/cwq047 · DOI
  73. 10.1038/ni1202 · DOI
  74. 10.1128/AAC.01638-09 · DOI · Paper page
  75. 10.1128/JB.06178-11 · DOI
  76. 10.1093/nar/gkq869 · DOI
  77. 10.1006/jmbi.2001.5038 · DOI
  78. 10.2165/11317030-000000000-00000 · DOI
  79. 10.1073/pnas.0510322103 · DOI
  80. 10.1016/j.mib.2008.11.010 · DOI
  81. 10.1016/j.mib.2008.01.006 · DOI
  82. 10.1099/mic.0.2008/016840-0 · DOI
  83. 10.1016/j.chom.2010.06.012 · DOI
  84. 10.1016/j.tim.2010.09.001 · DOI
  85. 10.1371/journal.ppat.1001068 · DOI
  86. 10.1126/science.1128393 · DOI
  87. 10.1038/emboj.2008.269 · DOI
  88. 10.1016/j.tim.2012.02.004 · DOI
  89. 10.1038/35101627 · DOI
  90. 10.1186/1471-2180-10-294 · DOI
  91. 10.1128/AAC.45.6.1761-1770.2001 · DOI
  92. 10.1128/AAC.49.9.3858-3867.2005 · DOI
  93. 10.1128/AAC.00601-07 · DOI
  94. 10.1046/j.1365-2958.2003.03677.x · DOI
  95. 10.1128/JB.00720-06 · DOI
  96. 10.1111/j.1365-2958.2008.06152.x · DOI
  97. 10.1128/AAC.00617-11 · DOI
  98. 10.1111/j.1462-2920.2008.01747.x · DOI
  99. 10.1111/j.1365-2958.2008.06132.x · DOI
  100. 10.5301/ijao.5000027 · DOI
  101. 10.1038/nature03912 · DOI
  102. 10.1126/science.1211037 · DOI
  103. 10.1098/rstb.2007.2044 · DOI

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Metadata

Authors
Mah, T.-F.
Venue
Future Microbiology
Publisher
Informa UK Limited
Published
2012-09
Volume
7
Issue
9
Pages
1061-1072
ISSN
  • 1746-0913
  • 1746-0921
DOI
10.2217/fmb.12.76
Cited by
504
References
5
Language
en
Funders
  • Natural Sciences and Engineering Research Council of Canada
  • Cystic Fibrosis Canada

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CoChat. (2026). Citation check: Biofilm-Specific Antibiotic Resistance. https://app.cochat.ai/papers/10.2217/fmb.12.76
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Mah, T.-F. (2012). Biofilm-Specific Antibiotic Resistance. Future Microbiology. https://doi.org/10.2217/fmb.12.76