Cited by 104Antifungal resistance and susceptibilityFungal and yeast genetics researchFungal Infections and Studies

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Candida albicans specializations for iron homeostasis: from commensalism to virulence

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Noble, Suzanne M·2013·Current Opinion in Microbiology

DOI 10.1016/j.mib.2013.09.006PMC PMC3855070

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Abstract

Candida albicans is a fungal commensal-pathogen that persistently associates with its mammalian hosts. Between the commensal and pathogenic lifestyles, this microorganism inhabits host niches that differ markedly in the levels of bioavailable iron. A number of recent studies have exposed C. albicans specializations for acquiring iron from specific host molecules in regions where iron is scarce, while also defending against iron-related toxicity in regions where iron occurs in surfeit. Together, these results point to a central role for iron homeostasis in the evolution of this important human pathogen.

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“They regulate hyphal development and morphological transitions by modulating key transcription factors, including Sef1 , Hap43 , and Sfu1 (Noble 2013; Singh et al. 2011).”
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Authors: Noble, S. M.
Affiliations: University of California, San Francisco (US)
Corresponding author: Noble, Suzanne M
ORCID: Noble, Suzanne M
Venue: Current Opinion in Microbiology
Publisher: Elsevier BV
Published: 2013-12
Volume: 16
Issue: 6
Pages: 708-715
ISSN: 1369-5274 (ISSN-L)
DOI: 10.1016/j.mib.2013.09.006
PMC: PMC3855070
OpenAlex: W2093869242
Cited by: 104
References: 83
Citations by year: 2026: 5 · 2025: 10 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 7 · 2014: 4 · 2013: 1
FWCI: 0.89
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Microbiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: Burroughs Wellcome Fund
Pew Charitable Trusts
National Institutes of Health (R21AI099659-01)
Topics: Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
Keywords: Candida albicans, iron homeostasis, iron acquisition, iron toxicity, commensalism, fungal virulence, host-pathogen interaction, iron starvation
MeSH terms: Candida albicans, Homeostasis, Iron, Symbiosis, Virulence

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Candida albicans specializations for iron homeostasis: from commensalism to virulence

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