The DOI matches its Crossref record; 80 of the 83 references it cites were found in a registry or an index.
Candida albicans specializations for iron homeostasis: from commensalism to virulence
Open accessAbstract
Candida albicans is a fungal commensal-pathogen that persistently associates with its mammalian hosts. Between the commensal and pathogenic lifestyles, this microorganism inhabits host niches that differ markedly in the levels of bioavailable iron. A number of recent studies have exposed C. albicans specializations for acquiring iron from specific host molecules in regions where iron is scarce, while also defending against iron-related toxicity in regions where iron occurs in surfeit. Together, these results point to a central role for iron homeostasis in the evolution of this important human pathogen.
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“Elevated concentrations of hepcidin increase iron sequestration by macrophages and decrease duodenal iron absorption during inflammatory reactions and thus reduces plasma iron levels (Cassat and Skaar, 2013; Noble, 2013).”
From Iron at the Centre of Candida albicans Interactions (2018) · cites this paper as Noble, 2013
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“They regulate hyphal development and morphological transitions by modulating key transcription factors, including Sef1, Hap43, and Sfu1 (Noble 2013; Singh et al. 2011).”
From Aloe emodin disrupts Candida albicans mitochondrial iron homeostasis against its hyphal development and oral candidiasis (2026) · cites this paper as Noble 2013
Experimental — accuracy not yet measuredIn the citing paper
“Thus, C. albicans has evolved an intricate transcriptional program to regulate iron acquisition during commensal or pathogenic states [91].”
From Buried Treasure: Evolutionary Perspectives on Microbial Iron Piracy (2015) · cites this paper as [91]
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Cites
Wisplinghoff, H., Bischoff, T., Tallent, S. M., Seifert, H., Wenzel, R. P., & Edmond, M. B. (2004) · Clinical Infectious Diseases · doi:10.1086/421946 · Cited by 4,496
Andrews, N. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412607 · Cited by 2,130
Nosocomial Bloodstream Infections in United States Hospitals: A Three‐Year Analysis
Edmond, M. B., Wallace, S. E., McClish, D. K., Pfaller, M. A., Jones, R. N., & Wenzel, R. P. (1999) · Clinical Infectious Diseases · doi:10.1086/520192 · Cited by 1,387
Enterobactin: an archetype for microbial iron transport.
Raymond, K. N., Dertz, E. A., & Kim, S. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0630018100 · Cited by 933
Chemistry and biology of eukaryotic iron metabolism
Aisen, P. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00063-2 · Cited by 804
Genetics and Assembly Line Enzymology of Siderophore Biosynthesis in Bacteria
Crosa, J. H., & Walsh, C. T. (2002) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.66.2.223-249.2002 · Cited by 797
The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts
Skaar, E. P. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000949 · Cited by 796
Zaoutis, T. E., Argon, J., Chu, J., Berlin, J. A., Walsh, T. J., & Feudtner, C. (2005) · Clinical Infectious Diseases · doi:10.1086/496922 · Cited by 784
Blumberg, H. M., Jarvis, W. R., Soucie, J. M., Edwards, J. E., Patterson, J. E., Pfaller, M. A., Rangel‐Frausto, M. S., Rinaldi, M. G., Saiman, L., Wiblin, R. T., et al. (2001) · Clinical Infectious Diseases · doi:10.1086/321811 · Cited by 661
Hajjeh, R. A., Sofair, A. N., Harrison, L. H., Lyon, G. M., Arthington-Skaggs, B. A., Mirza, S. A., Phelan, M., Morgan, J., Lee-Yang, W., Ciblak, M. A., et al. (2004) · Journal of Clinical Microbiology · doi:10.1128/jcm.42.4.1519-1527.2004 · Cited by 649
Flagged first, then by citations
3 of the 83 references couldn’t be matched to a known paper.
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Items 101–104 of 104
Assessment of the metabolome in genomically diverse Candida albicans isolates
Alaban, L. R. (2022) · theses.fr (ABES) · doi:10.70675/6127ebd7z2b67z4728z960dzdc64762b4c70
zhang, Y., Yang, Q., Zhang, X., Dhanasekaran, S., Bai, X., Sun, P., Zhang, W., Chen, X., Asanda, M., & Zhang, H. (2026) · Food Microbiology · doi:10.1016/j.fm.2026.105173
He, J., Yang, Y., Hongxia, Y., Niu, J., Zhang, D., Chen, F., Zhang, Q., Liang, J., Wu, Z., Yao, K., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2026.103003
Iron acquisition mechanisms of human skin-associated fungi
Jeon, J., Shin, J., & Jung, W. H. (2026) · FEMS Yeast Research · doi:10.1093/femsyr/foag045
Metadata
- Authors
- Noble, S. M.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Noble, Suzanne M
- ORCID
- Noble, Suzanne M
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2013-12
- Volume
- 16
- Issue
- 6
- Pages
- 708-715
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC3855070
- OpenAlex
- W2093869242
- Cited by
- 104
- References
- 83
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 17 · 2016: 9 · 2015: 7 · 2014: 4 · 2013: 1
- FWCI
- 0.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Burroughs Wellcome Fund
- Pew Charitable Trusts
- National Institutes of Health (R21AI099659-01)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Health Sciences › Medicine › Infectious Diseases › Fungal Infections and Studies
- Keywords
- Candida albicans, iron homeostasis, iron acquisition, iron toxicity, commensalism, fungal virulence, host-pathogen interaction, iron starvation
- MeSH terms
- Candida albicans, Homeostasis, Iron, Symbiosis, Virulence
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