The role of mitochondria in fungal aging
Abstract
Time-dependent impairments of mitochondrial function play a key role in biological aging. Work on fungal aging models has been instrumental in unraveling basic mechanisms leading to mitochondrial dysfunction and the identification of different pathways active in keeping mitochondria 'healthy' over time. Pathways including those involved in reactive oxygen scavenging, repair of damage, proteostasis, mitochondrial dynamics, and biogenesis, are interconnected and part of a complex quality control system. The individual components of this network are limited in capacity. However, if the capacity of one pathway is overwhelmed, another one may be activated. The mechanisms controlling the underlying cross-talk are poorly understood and subject of intensive investigation.
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The pro-apoptotic role of ROS, mitochondrial DNA rearrangements and release of pro-apoptotic factors from permeabilized mitochondria suggests that a failure in mitochondrial maintenance may contribute to the increased sensitivity to PCD during fungal aging.
“The pro-apoptotic role of ROS, mitochondrial DNA rearrangements and release of pro-apoptotic factors from permeabilized mitochondria suggests that a failure in mitochondrial maintenance may contribute to the increased sensitivity to PCD during fungal aging(Bernhardt et al., 2014), similar to the situation in mammals.”
From Programmed cell death in aging (2015) · cites this paper as Bernhardt et al., 2014
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References 52 · Cited by 23
- Authors
- Bernhardt, D., Hamann, A., & Osiewacz, H. D.
- Affiliations
- Goethe University Frankfurt (DE)
- Corresponding author
- Osiewacz, Heinz D
- ORCID
- Osiewacz, Heinz D
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 22
- Pages
- 1-7
- ISSN
- 1369-5274 (ISSN-L)
- OpenAlex
- W2043843825
- Cited by
- 23
- References
- 52
- Citations by year
- 2025: 1 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 3
- FWCI
- 0.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- German Ministry of Education and Research (FKZ0315584A)
- Deutsche Forschungsgemeinschaft (Os75/15-1)
- Frankfurt Autophagy Network
- Center of Membrane Proteomics (CMP)
- Cluster of Excellence Frankfurt ‘Macromolecular Complexes’
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Keywords
- mitochondrial dysfunction, fungal aging, biological aging, reactive oxygen species scavenging, proteostasis, mitochondrial dynamics, mitochondrial biogenesis, mitochondrial quality control
- MeSH terms
- DNA, Mitochondrial, Energy Metabolism, Fungi, Mitochondria, Oxygen Consumption, Protein Processing, Post-Translational, Apoptosis, Mitochondrial Dynamics
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