A titanic drug resistance threat in Cryptococcus neoformans
Open accessAbstract
Increasing resistance to frontline antifungals is a growing threat to global health. In the face of high rates of relapse for patients with cryptococcal meningitis and frequent drug resistance in clinical isolates, recent insights into Cryptococcus neoformans morphogenesis and genome plasticity take on new and urgent meaning. Here we review the state of the understanding of mechanisms of drug resistance in the context of host-relevant changes in Cryptococcus morphology and cell ploidy.
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Titan cells exhibit numerous alterations that likely contribute to drug resistance.
“the formation of Cryptococcus titan cells, which exhibit numerous alterations that likely contribute to drug resistance43 (Box 2).”
From Treatment strategies for cryptococcal infection: challenges, advances and future outlook (2021) · cites this paper as [43]
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References 84 · Cited by 76
Research works printed but not linked: 1
- [1]O’Neill J Tackling Drug-Resistance Infections Globally: A Final Report and Recommendations InReview on Antimicrobial Resistance 2016 Wellcome Trust, London, UK https://amr-review.org/.
- Authors
- Zafar, H., Altamirano, S., Ballou, E. R., & Nielsen, K.
- Affiliations
- University of Birmingham (GB)
- University of Minnesota (US)
- Corresponding author
- Ballou, Elizabeth R
- Nielsen, Kirsten
- Venue
- Current Opinion in Microbiology
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 52
- Pages
- 158-164
- ISSN
- 1369-5274 (ISSN-L)
- PMC
- PMC6941473
- OpenAlex
- W2991039487
- Cited by
- 76
- References
- 84
- Citations by year
- 2026: 11 · 2025: 15 · 2024: 13 · 2023: 14 · 2022: 11 · 2021: 7 · 2020: 4
- FWCI
- 0.80
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (R01AI134636, K12GM119955)
- Royal Society (R01AI134636)
- Foundation for the National Institutes of Health (K12GM119955)
- Society of Interventional Radiology
- Wellcome Trust (211241/Z/18/Z)
- National Centre for the Replacement Refinement and Reduction of Animals in Research (NC/R001472/1)
- Topics
- Health Sciences › Medicine › Epidemiology › Fungal Infections and Studies
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Immunology and Microbiology › Microbiology › Bacterial Infections and Vaccines
- Keywords
- Cryptococcus neoformans, antifungal resistance, cryptococcal meningitis, morphogenesis, genome plasticity, cell ploidy, relapse, host-pathogen interaction
- MeSH terms
- Antifungal Agents, Cryptococcosis, Cryptococcus neoformans, Humans, Microbial Sensitivity Tests, Respiratory Tract Infections, Meningitis, Cryptococcal, Drug Resistance, Multiple, Fungal
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