Vitamin D supplementation promotes macrophages' anti-mycobacterial activity in type 2 diabetes mellitus patients with low vitamin D receptor expression
Open accessAbstract
The increasing number of people with type 2 diabetes (DM2) is alarming and if it is taken into account that the relative odds of developing tuberculosis in diabetic patients ranges from 2.44 to 8.33 compared with non-diabetic patients, thus in developing countries where these two diseases are encountering face to face, there is a need for prophylaxis strategies. The role of vitamin D has been widely implicated in growth control of Mycobacterium tuberculosis (Mtb) during primary infection mainly through the induction of certain antimicrobial peptides (AMPs). In this study we evaluated the vitamin D serum levels, CYP27B1-hydroxylase enzyme, vitamin D receptor (VDR) and AMPs gene expression in Healthy donors, DM2 and TB patients. Results showed that DM2 group has lower VDR and AMPs expression levels. When Monocytes Derived Macrophages (MDM) from DM2 patients with low VDR expression were supplemented with vitamin D, MDMs eliminate efficiently M. tuberculosis. This preliminary study suggests the use of vitamin D as prophylaxis for tuberculosis in high DM2 endemic countries.
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Macrophages from diabetic patients with low vitamin D2 levels have impaired control of M. tuberculosis infection ex vivo, which can be significantly augmented upon vitamin D supplementation.
“Accordingly, macrophages from diabetic patients with low vitamin D2 levels were shown to have an impaired control of M. tuberculosis infection ex vivo, which can be significantly augmented upon vitamin D supplementation (86).”
From Macrophage defense mechanisms against intracellular bacteria (2015) · cites this paper as [86]
Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860 · see citing works
Diagnosis and Classification of Diabetes Mellitus
American Diabetes Association (2010) · Diabetes Care · doi:10.2337/dc11-s062 · Cited by 14,019 · see citing works
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Liu, P. T., Stenger, S., Li, H., Wenzel, L., Tan, B. H., Krutzik, S. R., Ochoa, M. T., Schauber, J., Wu, K., Meinken, C., et al. (2006) · Science · doi:10.1126/science.1123933 · Cited by 3,924 · see citing works
Diagnosis and Classification of diabetes mellitus
Rossi, G. (2014) · Diapedia.org eBooks · doi:10.14496/dia..20 · Cited by 3,212 · see citing works
Tuberculosis and diabetes mellitus: convergence of two epidemics
Dooley, K. E., & Chaisson, R. E. (2009) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(09)70282-8 · Cited by 934 · see citing works
Liu, P. T., Stenger, S., Tang, D. H., & Modlin, R. L. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2060 · Cited by 773 · see citing works
Wilkinson, R. J., Llewelyn, M., Toossi, Z., Patel, P., Pasvol, G., Lalvani, A., Wright, D. J., Latif, M., & Davidson, R. N. (2000) · The Lancet · doi:10.1016/s0140-6736(99)02301-6 · Cited by 768 · see citing works
The Population Dynamics and Control of Tuberculosis
Dye, C., & Williams, B. G. (2010) · Science · doi:10.1126/science.1185449 · Cited by 604 · see citing works
Role of vitamin D in the pathogenesis of type 2 diabetes mellitus
Palomer, X., González‐Clemente, J. M., Blanco‐Vaca, F., & Mauricio, D. (2007) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2007.00710.x · Cited by 510 · see citing works
Vitamin D Signaling, Infectious Diseases, and Regulation of Innate Immunity
White, J. H. (2008) · Infection and Immunity · doi:10.1128/iai.00353-08 · Cited by 381 · see citing works
Global tuberculosis control report.
Thakur, M. (2001) · PubMed · Cited by 294 · see citing works
Impact of Diabetes Mellitus on Treatment Outcomes of Patients with Active Tuberculosis
Dooley, K. E., Tang, T., Golub, J. E., Dorman, S. E., & Cronin, W. A. (2009) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2009.80.634 · Cited by 257 · see citing works
Vitamin D and Innate and Adaptive Immunity
Hewison, M. (2011) · Vitamins and hormones · doi:10.1016/b978-0-12-386960-9.00002-2 · Cited by 239 · see citing works
Escobedo, J., Schargrodsky, H., Champagne, B. M., Silva, H., Boissonnet, C. P., Vinueza, R., Torres, M., Hernández, R. H., & Wilson, E. (2009) · Cardiovascular Diabetology · doi:10.1186/1475-2840-8-52 · Cited by 173 · see citing works
Vitamin D metabolism and innate immunity
Lagishetty, V., Liu, N. Q., & Hewison, M. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.04.015 · Cited by 156 · see citing works
Smolders, J., Schuurman, K. G., van Strien, M. E., Melief, J., Hendrickx, D. A. E., Hol, E. M., van Eden, C. G., Luchetti, S., & Huitinga, I. (2013) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e31827f4fcc · Cited by 132 · see citing works
Rivas-Santiago, B. T., Rivas-Santiago, C., Castañeda‐Delgado, J. E., León‐Contreras, J. C., Hancock, R. E. W., & Hernández‐Pando, R. (2012) · International Journal of Antimicrobial Agents · doi:10.1016/j.ijantimicag.2012.09.015 · Cited by 130 · see citing works
Self-citationWielders, J. P. M., & Wijnberg, F. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2008.117366 · Cited by 115 · see citing works
Yamshchikov, A. V., Kurbatova, E. V., Kumari, M., Blumberg, H. M., Ziegler, T. R., Ray, S. M., & Tangpricha, V. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2010.29411 · Cited by 107 · see citing works
Chun, R. F., Peercy, B. E., Adams, J. S., & Hewison, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030773 · Cited by 102 · see citing works
Mily, A., Rekha, R. S., Kamal, S. M. M., Akhtar, E., Sarker, P., Rahim, Z., Gudmundsson, G. H., Agerberth, B., & Raqib, R. (2013) · BMC Pulmonary Medicine · doi:10.1186/1471-2466-13-23 · Cited by 92 · see citing works
Campbell, G. R., & Spector, S. A. (2012) · Autophagy · doi:10.4161/auto.21154 · Cited by 89 · see citing works
High prevalence of diabetes and impaired fasting glucose in urban Latin America: the CARMELA Study
Escobedo, J., Buitrón, L. V., Velasco, M. F., Ramírez, J. C., Hernandez, R. C. D., Macchia, A., Pellegrini, F., Schargrodsky, H., Boissonnet, C. P., Champagne, B. M., et al. (2009) · Diabetic Medicine · doi:10.1111/j.1464-5491.2009.02795.x · Cited by 85 · see citing works
Gonzalez-Curiel, I. E., Castañeda‐Delgado, J. E., López‐López, N., Araujo, Z., Hernández‐Pando, R., Gándara-Jasso, B., Macías-Segura, N., Enciso‐Moreno, J. A., & Rivas-Santiago, B. T. (2011) · Human Immunology · doi:10.1016/j.humimm.2011.03.027 · Cited by 76 · see citing works
Self-citationVitamin D deficiency and severe asthma
Poon, A. H., Mahboub, B. H., & Hamid, Q. A. (2013) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2013.06.006 · Cited by 57 · see citing works
Larcombe, L., Mookherjee, N., Slater, J. J., Slivinski, C., Singer, M., Whaley, C., Denechezhe, L., Matyas, S., Turner-Brannen, E., Nickerson, P. W., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0049872 · Cited by 51 · see citing works
Vitamin D in Early Childhood and the Effect on Immunity toMycobacterium tuberculosis
Battersby, A., Kampmann, B., & Burl, S. (2012) · Clinical and Developmental Immunology · doi:10.1155/2012/430972 · Cited by 48 · see citing works
Castañeda‐Delgado, J. E., Hernández‐Pando, R., Serrano, C. J., et al. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04199.x · Cited by 40 · see citing works
Self-citationLarcombe, L., Orr, P., Turner-Brannen, E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0040692 · Cited by 37 · see citing works
Kibirige, D., Mutebi, E. I., Ssekitoleko, R., et al. (2013) · BMC Research Notes · doi:10.1186/1756-0500-6-293 · Cited by 35 · see citing works
Immunotherapy for Pulmonary Tb: Antimicrobial Peptides and their Inducers
Rivas-Santiago, C., Hernández‐Pando, R., & Rivas-Santiago, B. T. (2013) · Immunotherapy · doi:10.2217/imt.13.111 · Cited by 20 · see citing works
Self-citationBiochemical Characteristics and Risk Factors for Insulin Resistance at Different Levels of Obesity
Guerrero‐Romero, F., Aradillas-García, C., Simental‐Mendía, L. E., Torres-Rodríguez, M. L., Mendoza, E. D. L. C., Rosales-Cervantes, J., Ramírez, G. R., & Rodríguez‐Morán, M. (2013) · PEDIATRICS · doi:10.1542/peds.2012-1421 · Cited by 18 · see citing works
Coronary artery vitamin D receptor expression and plasma concentrations of 25-hydroxyvitamin D
Schnatz, P. F., Nudy, M. S., O’Sullivan, D. M., Jiang, X., Cline, J. M., Kaplan, J. R., Clarkson, T. B., & Appt, S. E. (2012) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31824cfa8f · Cited by 17 · see citing works
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Macrophage defense mechanisms against intracellular bacteria
Weiss, G., & Schaible, U. E. (2015) · Immunological Reviews · doi:10.1111/imr.12266 · Cited by 989 · see citing works
- Authors
- Lopez-Lopez, N., Gonzalez-Curiel, I., Castañeda-Delgado, J., Montoya-Rosales, A., Gandara-Jasso, B., Enciso-Moreno, J. A., & Rivas-Santiago, B.
- Affiliations
- Mexican Social Security Institute (MX)
- Corresponding author
- Rivas-Santiago, Bruno
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 16
- Issue
- 9
- Pages
- 755-761
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W1980335559
- Cited by
- 25
- References
- 33
- Citations by year
- 2024: 3 · 2022: 2 · 2021: 2 · 2020: 1 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 3 · 2015: 4
- FWCI
- 2.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mexican Institute (FIS/IMSS/PROT/G11/955)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Tuberculosis Research and Epidemiology
- Health Sciences › Medicine › Pathology and Forensic Medicine › Vitamin D Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- vitamin D supplementation, type 2 diabetes, vitamin D receptor, Mycobacterium tuberculosis, tuberculosis, monocyte-derived macrophages, antimicrobial peptides, CYP27B1, tuberculosis prophylaxis, tuberculosis-diabetes comorbidity
- MeSH terms
- Adult, Aged, Cells, Cultured, Diabetes Mellitus, Type 2, Female, Humans, Macrophages, Male, Middle Aged, Mycobacterium tuberculosis, Vitamin D, 25-Hydroxyvitamin D3 1-alpha-Hydroxylase, Receptors, Calcitriol, Antimicrobial Cationic Peptides, Young Adult
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