Deferoxamine mesylate enhances virulence of community-associated methicillin resistant Staphylococcus aureus
Open accessAbstract
Staphylococcus aureus is a leading cause of bacterial infections. Strains of community-associated methicillin-resistant S. aureus (CA-MRSA), such as USA300, display enhanced virulence and fitness. Patients suffering from iron overload diseases often undergo iron chelation therapy with deferoxamine mesylate (DFO). Here, we show that USA300 uses this drug to acquire iron. We further demonstrate that mice administered DFO I.P., versus those not administered DFO, had significantly higher bacterial burden in livers and kidneys after I.V. challenge with USA300, associated with increased abscess formation and tissue destruction. The virulence of USA300 mutants defective for DFO uptake was not affected by DFO treatment.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Deferoxamine has been associated with promoting bacterial growth in multiple studies.
“Deferoxamine has been associated with promoting bacterial growth in multiple studies,29,30 whereas deferiprone at lower concentrations (data not shown) stimulated Y enterocolitica growth in vitro.”
From Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron (2017) · cites this paper as [29]
Cites
Iron in infection and immunity
Cassat, J. E., & Skaar, E. P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.04.010 · Cited by 1,214 · see citing works
Nutrition and the immune system from birth to old age
Chandra, R. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601492 · Cited by 369 · cited 1× · see citing works
“Hosts with low iron are at a higher risk of opportunistic infections, most likely due to impaired immunity [12].”
BackgroundSevere infections in thalassaemic patients: prevalence and predisposing factors
Rahav, G., Volach, V., Shapiro, M., Rund, D., Rachmilewitz, E. A., & Goldfarb, A. (2006) · British Journal of Haematology · doi:10.1111/j.1365-2141.2006.06082.x · Cited by 79 · see citing works
Sheldon, J. R., Marolda, C. L., & Heinrichs, D. E. (2014) · Molecular Microbiology · doi:10.1111/mmi.12593 · Cited by 62 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Iron acquisition strategies of bacterial pathogens
Sheldon, J. R., Laakso, H. A., & Heinrichs, D. E. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.vmbf-0010-2015 · Cited by 219 · see citing works
Stefanova, D., Raychev, A., Arezes, J., Ruchala, P., Gabayan, V., Skurnik, M., Dillon, B. J., Horwitz, M. A., Ganz, T., Bulut, Y., et al. (2017) · Blood · doi:10.1182/blood-2017-03-772715 · Cited by 145 · see citing works
Iron Acquisition Strategies of Bacterial Pathogens
Sheldon, J. R., Laakso, H. A., & Heinrichs, D. E. (2016) · Virulence Mechanisms of Bacterial Pathogens · doi:10.1128/9781555819286.ch3 · Cited by 25 · see citing works
Self-citationBatko, I. Z., Flannagan, R. S., Guariglia-Oropeza, V., Sheldon, J. R., & Heinrichs, D. E. (2021) · Journal of Bacteriology · doi:10.1128/jb.00458-21 · Cited by 19 · see citing works
Self-citation
- Authors
- Arifin, A. J., Hannauer, M., Welch, I., & Heinrichs, D. E.
- Affiliations
- Western University (CA)
- Corresponding author
- Heinrichs, David E.
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2014-11
- Volume
- 16
- Issue
- 11
- Pages
- 967-972
- ISSN
- 1286-4579 (ISSN-L)
- OpenAlex
- W2028512317
- Cited by
- 26
- References
- 4
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 2 · 2023: 1 · 2022: 3 · 2021: 1 · 2017: 5 · 2016: 6 · 2015: 3
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (MOP-38002)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antimicrobial Resistance in Staphylococcus
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Keywords
- deferoxamine mesylate, community-associated methicillin-resistant Staphylococcus aureus, USA300, bacterial virulence, iron acquisition, iron chelation therapy, iron overload, bacterial fitness, abscess formation, tissue destruction, bacterial load
- MeSH terms
- Abscess, Animals, Animal Structures, Deferoxamine, Disease Models, Animal, Female, Iron, Kidney, Liver, Mice, Inbred BALB C, Staphylococcal Infections, Virulence, Siderophores, Methicillin-Resistant Staphylococcus aureus, Bacterial Load
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
