Colonization and effector functions of innate lymphoid cells in mucosal tissues
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Innate lymphoid cells (ILCs) protect mucosal barrier tissues to fight infection and maintain tissue integrity. ILCs and their progenitors are developmentally programmed to migrate, differentiate and populate various mucosal tissues and associated lymphoid tissues. Functionally mature ILC subsets respond to diverse pathogens such as bacteria, viruses, fungi and parasites in subset-specific manners. In this review, we will discuss how ILCs populate mucosal tissues and regulate immune responses to distinct pathogens to protect the host and maintain tissue integrity.
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Recent studies have shown that AHR influences the maintenance of certain resident immune cells, such as innate lymphoid cells in the gut, while also aiding in the orchestration of immune responses such as cytokine production.
“Recent studies have expanded upon these early characterizations to show that AHR influences the maintenance of certain resident immune cells, such as innate lymphoid cells in the gut, while also aiding in the orchestration of immune responses such as cytokine production (Cella & Colonna, 2015; Eberl et al., 2015; M. Kim & Kim, 2016; Zhou, 2016).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as M. Kim & Kim, 2016
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BackgroundRequirement of Interleukin‐17A for Systemic Anti– <i>Candida albicans</i> Host Defense in Mice
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“The red arrows represent loxP sites. the orchestration of immune responses such as cytokine production (Cella and Colonna 2015; Eberl et al. 2015; Kim and Kim 2016; Zhou 2016).”
BackgroundBalakumar, A., Cox, A., & Thangamani, S. (2024) · mSphere · doi:10.1128/msphere.00734-24 · Cited by 12 · see citing works
- Authors
- Kim, M., & Kim, C. H.
- Affiliations
- Purdue University West Lafayette (US)
- Corresponding author
- Kim, Chang H.
- Venue
- Microbes and Infection
- Publisher
- Elsevier BV
- Published
- 2016-10
- Volume
- 18
- Issue
- 10
- Pages
- 604-614
- ISSN
- 1286-4579 (ISSN-L)
- PMC
- PMC5050099
- OpenAlex
- W2470752490
- Cited by
- 16
- References
- 5
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 2 · 2018: 4 · 2017: 1
- FWCI
- 0.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Microbes and Infection (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- NIH (R01AI074745, R01DK076616, 1S10RR02829, R01AI080769)
- National Multiple Sclerosis Society
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- innate lymphoid cells, mucosal immunity, mucosal colonization, tissue colonization, mucosal barrier, host defense against infection, tissue integrity
- MeSH terms
- Animals, Bacteria, Fungi, Humans, Immunity, Innate, Lymphocytes, Mucous Membrane, Parasites, Viruses, Immunity, Mucosal
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