Cited by 1,136Gut microbiota and healthImmune Response and InflammationT-cell and B-cell Immunology

Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut

Artis, David·2008·Nature reviews. Immunology

Abstract

Mucosal surfaces such as the intestinal tract are continuously exposed to both potential pathogens and beneficial commensal microorganisms. This creates a requirement for a homeostatic balance between tolerance and immunity that represents a unique regulatory challenge to the mucosal immune system. Recent findings suggest that intestinal epithelial cells, although once considered a simple physical barrier, are a crucial cell lineage for maintaining intestinal immune homeostasis. This Review discusses recent findings that identify a cardinal role for epithelial cells in sampling the intestinal microenvironment, discriminating pathogenic and commensal microorganisms and influencing the function of antigen-presenting cells and lymphocytes.

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Crossref · 10.1038/nri2316

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  • The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.

    “The host-microbiota relationship has been defined as the synergistic effect of microbial metabolites on host immunity, health and disease, energy metabolism, and cellular communication.59, 60, 61, 62, 63,64”

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Authors
Artis, D.
Affiliations
University of Pennsylvania (US)
Corresponding author
Artis, David
Venue
Nature reviews. Immunology
Published
2008-06
Volume
8
Issue
6
Pages
411-420
ISSN
  • 1474-1733 (ISSN-L)
  • 1474-1741
OpenAlex
W2025114863
Cited by
1,136
References
167
Citations by year
2026: 27 · 2025: 33 · 2024: 38 · 2023: 55 · 2022: 61 · 2021: 54 · 2020: 51 · 2019: 52 · 2018: 60 · 2017: 56 · 2016: 58 · 2015: 63 · 2014: 92 · 2013: 85 · 2012: 81
FWCI
6.91
Type
journal article
Language
en
Open access
closed
Locations
  • Nature reviews. Immunology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Cancer Institute (T32CA009140, T32-CA09140-30)
  • National Institute of General Medical Sciences (F31-GM82187, F31GM082187)
  • National Institute of Allergy and Infectious Diseases (AI74878, T32AI007532, R01AI074878, F32-AI72943, F32AI072943, R01AI061570, AI 61570)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
intestinal epithelial cells, commensal bacteria, immune homeostasis, mucosal immunity, host-microbe interactions, epithelial barrier function, antigen presentation, lymphocytes, pathogen discrimination, gut microbiota
MeSH terms
Animals, Bacteria, Gastric Mucosa, Homeostasis, Humans, Intestinal Mucosa

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