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Cited by 32Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsMicrobial Metabolism and Applications

Aureolic acids from a marine-derived Streptomyces sp. WBF16

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Lu, Jiansheng, Ma, Yihua, Liang, Jianjia, Xing, Yingying, Xi, Tao, Lu, Yuanyuan·2012·Microbiological Research
DOI 10.1016/j.micres.2012.06.001
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Abstract

A marine-derived actinomycete (Streptomyces sp. WBF16) exhibiting antitumor activities was investigated. The strain was identified using morphological, biochemical and genetic techniques. 16S rDNA sequence of the isolate indicated that it was most closely related to Streptomyces coelicolor A3 (2). Furthermore, a new aureolic acid (Chromomycin B, 1), along with Chromomycin A(2) (2) and Chromomycin A(3) (3) were isolated from its secondary metabolites. Their structures were determined by chemical and spectroscopic methods including 1D, 2D NMR and HRMS. Compounds 1-3 showed strong cytotoxicity against SGC7901, HepG2, A549, HCT116 and COC1 and HUVEC.

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  • Antitumor antibiotics include members of the anthracycline, actinomycin, and aureolic acid families.

    “Antitumor antibiotics are among the most important cancer chemotherapeutic agents and include members of the anthracycline, actinomycin, and aureolic acid families [19,34,214].”

    From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [214]

    The Introduction identifies aureolic acids as a family of antitumor antibiotics. It does not identify anthracyclines or actinomycins as antitumor-antibiotic families, so it supports only the aureolic-acid part of the attributed claim. No page number is available in our copy. (LLM, conf=0.88)

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Research works printed but not linked: 5

  1. Gottlieb D. An evolution of criteria and procedures used in the description and char- acterization of Streptomyces, a co-operative study. Appl Microbiol 1961;9:55-60.
  2. Hu YC, Ewpindola PDM, Stewart NA, Wei SG, Posner BA, Macmillan JB. Chro- momycin SA analogs from marine-derived Streptomyces sp. Bioorg Med Chem 2011;19:5183-9.
  3. Remers WA. The chemistry of antitumor antibiotics, vol. 1. Wiley-Interscience; 1979b, 1133-41.
  4. Skarbek JD, Speedie MK. In antitumor compounds of natural origin. Chem Biochem 1981;1:191-235.
  5. Staneck JL, Roberts GD. Simplified approach to identification of aerobic actino- mycetes by thinlayer chromatography. Appl Microbiol 1974;28:226-31.

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Authors
Lu, J., Ma, Y., Liang, J., Xing, Y., Xi, T., & Lu, Y.
Affiliations
China Pharmaceutical University (CN)
Corresponding author
  • Xi, Tao
  • Lu, Yuanyuan
ORCID
Venue
Microbiological Research
Publisher
Elsevier BV
Published
2012-12
Volume
167
Issue
10
Pages
590-595
ISSN
0944-5013 (ISSN-L)
DOI
10.1016/j.micres.2012.06.001
OpenAlex
W1993945753
Cited by
32
References
42
Citations by year
2026: 1 · 2023: 2 · 2022: 5 · 2020: 2 · 2019: 5 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 2
FWCI
1.87
Type
journal article
Language
en
Open access
Licence
Locations
  • Microbiological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Project Program of State Key Laboratory of Natural Medicines, China Pharmaceutical University (JKGQ201102)
  • National Nature Science Foundation of China for Young Scientists (81001395)
Topics
  • Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Microbial Metabolism and Applications
Keywords
Streptomyces, marine actinomycetes, secondary metabolites, anticancer activity, cytotoxicity, Streptomyces coelicolor, structure elucidation
MeSH terms
Cell Line, Chromomycins, Drug Screening Assays, Antitumor, Humans, Marine Biology, Plicamycin, Magnetic Resonance Spectroscopy, Streptomyces, HCT116 Cells, Cell Line, Tumor, Hep G2 Cells, Human Umbilical Vein Endothelial Cells

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