Characterization of retinoid-X receptor genes rxra, rxrba, rxrbb and rxrg during zebrafish development
Abstract
During development of vertebrate embryos, retinoic acid plays a variety of roles that are mediated by binding to retinoic acid receptors (Rars) and their heterodimerization partners, the retinoid receptors (Rxrs). Here, we characterize the expression patterns of four zebrafish rxr genes during development and provide an analysis of the phylogenetic relationships between zebrafish and tetrapod Rxr genes based on sequence similarities and conserved syntenies. This analysis prompted the renaming of several of the zebrafish rxr genes to match their tetrapod orthologs. Understanding phylogenetic relationships among Rxr genes and their expression patterns during development provides a foundation for future studies of Rxr functions.
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rxrga was previously reported to be expressed in neural crest tissues.
“previously reported to be expressed in neural crest tissues [64]–[67].”
rxrga is included in the co-enrichment list of melanocytes and iridophores.
“We also find a retinoic acid nuclear receptor subfamily member (rxrga) previously reported to be expressed in neural crest tissues [64]–[67].”
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Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
Hernandez, R. E., Putzke, A. P., Myers, J. P., Margaretha, L., & Moens, C. B. (2007) · Development · doi:10.1242/dev.02706 · Cited by 245 · see citing works
Higdon, C. W., Mitra, R. D., & Johnson, S. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067801 · Cited by 125 · see citing works
- Authors
- Tallafuss, A., Hale, L. A., Yan, Y.-L., Dudley, L., Eisen, J. S., & Postlethwait, J. H.
- Affiliations
- University of Oregon (US)
- Corresponding author
- Postlethwait, John H.
- Venue
- Gene Expression Patterns
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 6
- Issue
- 5
- Pages
- 556-565
- ISSN
- 1567-133X (ISSN-L)
- OpenAlex
- W2065092823
- Cited by
- 55
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 4 · 2022: 1 · 2021: 1 · 2019: 1 · 2017: 2 · 2016: 4 · 2015: 3 · 2014: 1 · 2013: 5 · 2012: 3
- FWCI
- 2.02
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gene Expression Patterns (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation (DGE-9972830)
- National Institutes of Health (5F32GM020892, GM007413, HD22486, NS23915, R01RR10715)
- American Heart Association (0420027Z)
- University of Oregon
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
- Keywords
- retinoid X receptor, retinoid X receptor alpha, retinoid X receptor beta, retinoid X receptor gamma, zebrafish development, retinoic acid signaling, phylogenetic relationships, gene nomenclature, synteny
- MeSH terms
- Animals, Base Sequence, Cloning, Molecular, Female, Phylogeny, Zebrafish, In Situ Hybridization, DNA Primers, Gene Expression Profiling, Retinoid X Receptors
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