Cyp26 enzymes generate the retinoic acid response pattern necessary for hindbrain development
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Retinoic acid (RA) is essential for normal vertebrate development, including the patterning of the central nervous system. During early embryogenesis, RA is produced in the trunk mesoderm through the metabolism of vitamin A derived from the maternal diet and behaves as a morphogen in the developing hindbrain where it specifies nested domains of Hox gene expression. The loss of endogenous sources of RA can be rescued by treatment with a uniform concentration of exogenous RA, indicating that domains of RA responsiveness can be shaped by mechanisms other than the simple diffusion of RA from a localized posterior source. Here, we show that the cytochrome p450 enzymes of the Cyp26 class, which metabolize RA into polar derivatives, function redundantly to shape RA-dependent gene-expression domains during hindbrain development. In zebrafish embryos depleted of the orthologs of the three mammalian CYP26 genes CYP26A1, CYP26B1 and CYP26C1, the entire hindbrain expresses RA-responsive genes that are normally restricted to nested domains in the posterior hindbrain. Furthermore, we show that Cyp26 enzymes are essential for exogenous RA to rescue hindbrain patterning in RA-depleted embryos. We present a ;gradient-free' model for hindbrain patterning in which differential RA responsiveness along the hindbrain anterior-posterior axis is shaped primarily by the dynamic expression of RA-degrading enzymes.
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In Cyp26a1 knockout zebrafish subjected to RA deficiency, a treatment of RA intended to rescue the fish caused teratogenic posteriorization of the hindbrain such as those found in wildtype fish exposed to 40 times that amount.
“In Cyp26a1 knockout (cyp26a1−/−) zebrafish subjected to RA deficiency, a treatment of RA intended to rescue the fish caused the fish to exhibit teratogenic posteriorization of the hindbrain such as those found in wildtype fish exposed to 40 times that amount [46].”
From Vitamin A Transporters in Visual Function: A Mini Review on Membrane Receptors for Dietary Vitamin A Uptake, Storage, and Transport to the Eye (2021) · cites this paper as [46]
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- Authors
- Hernandez, R. E., Putzke, A. P., Myers, J. P., Margaretha, L., & Moens, C. B.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Margaretha, Lilyana
- Moens, Cecilia B.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2007-01-01
- Volume
- 134
- Issue
- 1
- Pages
- 177-187
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- PMC
- PMC1765950
- OpenAlex
- W1978973930
- Cited by
- 245
- References
- 66
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 8 · 2023: 10 · 2022: 10 · 2021: 16 · 2020: 11 · 2019: 15 · 2018: 12 · 2017: 8 · 2016: 15 · 2015: 10 · 2014: 11 · 2013: 16 · 2012: 15
- FWCI
- 6.40
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Development (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Whitworth Digital Commons (Whitworth University) (submittedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM007266, T32GM07266)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37909, T32HD007183, R01HD037909, 2T32 HD07183)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinoids in leukemia and cellular processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- retinoic acid, hindbrain development, Hox gene expression, cytochrome P450, zebrafish, CYP26A1, CYP26B1, CYP26C1, anterior-posterior axis, morphogen signaling
- MeSH terms
- Animals, Cytochrome P-450 Enzyme System, Embryo, Nonmammalian, Genes, Homeobox, Models, Biological, Rhombencephalon, Tretinoin, Zebrafish, Oligonucleotides, Antisense, In Situ Hybridization, Gene Expression Regulation, Developmental, Body Patterning, Organogenesis, Embryonic Development
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