HDAC6 Regulates Hsp90 Acetylation and Chaperone-Dependent Activation of Glucocorticoid Receptor

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2. Targeting HDAC6 attenuates nicotine-induced macrophage pyroptosis via NF-κB/NLRP3 pathway
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3. Histone/protein deacetylases control Foxp3 expression and the heat shock response of T-regulatory cells
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4. SQSTM1/p62 Interacts with HDAC6 and Regulates Deacetylase Activity
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5. Inhibiting the HSP90 chaperone destabilizes macrophage migration inhibitory factor and thereby inhibits breast tumor progression
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6. Aberrant GlyRS-HDAC6 interaction linked to axonal transport deficits in Charcot-Marie-Tooth neuropathy
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7. Regulators of Oncogenic Mutant TP53 Gain of Function
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8. HDAC6 Modulates Hsp90 Chaperone Activity and Regulates Activation of Aryl Hydrocarbon Receptor Signaling
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9. Dual Degradation of Aurora A and B Kinases by the Histone Deacetylase Inhibitor LBH589 Induces G2-M Arrest and Apoptosis of Renal Cancer Cells
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10. Inhibition of Class IIb Histone Deacetylase Significantly Improves Cloning Efficiency in Mice1
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11. Proteotoxicity and Cardiac Dysfunction
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12. Hdac6 Knock-Out Increases Tubulin Acetylation but Does Not Modify Disease Progression in the R6/2 Mouse Model of Huntington's Disease
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13. Beyond Histone and Deacetylase: An Overview of Cytoplasmic Histone Deacetylases and Their Nonhistone Substrates
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14. Plant Responses to Abiotic Stress Regulated by Histone Deacetylases
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15. Glucocorticoids and Metabolic Control
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16. Inhibition of HDAC6 Activity Alleviates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats: Potential Role of Peroxiredoxin 1 Acetylation and Redox Regulation
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17. Targeting the histone orthography of cancer: drugs for writers, erasers and readers
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18. Minireview: New Molecular Mediators of Glucocorticoid Receptor Activity in Metabolic Tissues
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19. Histone Deacetylase Inhibitors Repress the Transactivation Potential of Hypoxia-inducible Factors Independently of Direct Acetylation of HIF-α
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20. Histone Deacetylase Inhibitors (HDI) Cause DNA Damage in Leukemia Cells: A Mechanism for Leukemia-Specific HDI-Dependent Apoptosis?
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21. Quinazolin-4-one Derivatives as Selective Histone Deacetylase-6 Inhibitors for the Treatment of Alzheimer’s Disease
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22. Bioactive natural products for chemoprevention and treatment of castration-resistant prostate cancer
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23. HDAC11 is a regulator of diverse immune functions
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24. Design, Synthesis, Structure−Selectivity Relationship, and Effect on Human Cancer Cells of a Novel Series of Histone Deacetylase 6-Selective Inhibitors
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25. Suppression of GATA-3 Nuclear Import and Phosphorylation: A Novel Mechanism of Corticosteroid Action in Allergic Disease
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26. Oxidative stress induced lung cancer and COPD: opportunities for epigenetic therapy
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27. HSP90 Molecular Chaperones, Metabolic Rewiring, and Epigenetics: Impact on Tumor Progression and Perspective for Anticancer Therapy
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28. Highly Potent and Selective Histone Deacetylase 6 Inhibitors Designed Based on a Small-Molecular Substrate
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29. Deacetylation of Nonhistone Proteins by HDACs and the Implications in Cancer
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30. Inclusion body formation, macroautophagy, and the role of HDAC6 in neurodegeneration
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31. Paxillin inhibits HDAC6 to regulate microtubule acetylation, Golgi structure, and polarized migration
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32. The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders
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33. Aggregation of the nucleic acid–binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation
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34. PKC alpha regulates Sendai virus‐mediated interferon induction through HDAC6 and β‐catenin
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35. Huntington Disease and the Huntingtin Protein
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36. Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors
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37. Chemical and structural biology of protein lysine deacetylases
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38. HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension
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39. Regulation of protein turnover by heat shock proteins
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40. Histone Deacetylase Inhibitors as Novel Anticancer Therapeutics
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41. An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline
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42. SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
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43. Glucocorticoids in the Treatment of Glomerular Diseases
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44. The novel histone de acetylase 6 inhibitor, MPT0G211, ameliorates tau phosphorylation and cognitive deficits in an Alzheimer’s disease model
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45. Berberine Suppresses Androgen Receptor Signaling in Prostate Cancer
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46. Cotreatment with Vorinostat (Suberoylanilide Hydroxamic Acid) Enhances Activity of Dasatinib (BMS-354825) against Imatinib Mesylate–Sensitive or Imatinib Mesylate–Resistant Chronic Myelogenous Leukemia Cells
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47. Advances in the discovery and development of heat-shock protein 90 inhibitors for cancer treatment
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48. Histone Deacetylase 6 Inhibits Influenza A Virus Release by Downregulating the Trafficking of Viral Components to the Plasma Membrane via Its Substrate, Acetylated Microtubules
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49. Molecular Aspects of the Stress Response: Chaperones, Membranes and Networks
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51. Histone Deacetylase Inhibitors in the Treatment of Hematological Malignancies and Solid Tumors
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53. HDAC as onco target: Reviewing the synthetic approaches with SAR study of their inhibitors
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54. Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next
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55. Histone Deacetylase Inhibitors Suppress the Inducibility of Nuclear Factor-κB by Tumor Necrosis Factor-α Receptor-1 Down-regulation
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56. The fungal Achilles’ heel: targeting Hsp90 to cripple fungal pathogens
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57. Metabolic reprogramming by class I and II histone deacetylases
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58. Pharmacologic and genetic inhibition of hsp90-dependent trafficking reduces aggregation and promotes degradation of the expanded glutamine androgen receptor without stress protein induction
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59. Regulation of molecular chaperones through post-translational modifications: Decrypting the chaperone code
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60. Alternative systems for misfolded protein clearance: life beyond the proteasome
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61. Hsp90 Regulates Activation of Interferon Regulatory Factor 3 and TBK-1 Stabilization in Sendai Virus-infected Cells
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62. Lymphocyte Chemotaxis Is Regulated by Histone Deacetylase 6, Independently of Its Deacetylase Activity
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63. The Hsp90 Cochaperone p23 Is Essential for Perinatal Survival
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64. Histone deacetylase isoforms regulate innate immune responses by deacetylating mitogen-activated protein kinase phosphatase-1
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65. HDAC6: A unique HDAC family member as a cancer target
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66. Histone Deacetylase Inhibitors for Cancer Therapy
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67. A mutation in the 3′-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia
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68. Histone deacetylase inhibitors prevent the degradation and restore the activity of glucocerebrosidase in Gaucher disease
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69. Histone Deacetylase 6 (HDAC6) Is an Essential Modifier of Glucocorticoid-Induced Hepatic Gluconeogenesis
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70. Molecular Interaction Network of the Hsp90 Chaperone System
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72. HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70
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73. The Hsp90 chaperone network modulates Candida virulence traits
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74. Microtubule acetylation but not detyrosination promotes focal adhesion dynamics and astrocyte migration
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75. Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors
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76. HDAC6 mutations rescue human tau-induced microtubule defects in Drosophila
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77. Heat shock proteins as hallmarks of cancer: insights from molecular mechanisms to therapeutic strategies
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78. Drug Insight: histone deacetylase inhibitor-based therapies for cutaneous T-cell lymphomas
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82. Signal transduction therapy of cancer
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83. Depletion of HDAC6 Enhances Cisplatin-Induced DNA Damage and Apoptosis in Non-Small Cell Lung Cancer Cells
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88. The therapeutic hope for HDAC6 inhibitors in malignancy and chronic disease
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89. Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer
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90. HDAC Inhibitors: Dissecting Mechanisms of Action to Counter Tumor Heterogeneity
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100. Human histone deacetylase 6 shows strong preference for tubulin dimers over assembled microtubules
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