MDM2 Promotes Proteasome-Dependent Ubiquitin-Independent Degradation of Retinoblastoma Protein

Sdek, Patima, Ying, Haoqiang, Chang, Donny L.F., Qiu, Wei, Zheng, Hongwu, Touitou, Robert, Allday, Martin J., Jim Xiao, Zhi-Xiong·2005·Molecular Cell

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Items 201–296 of 296

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  5. Timely Activation of Budding Yeast APCCdh1 Involves Degradation of Its Inhibitor, Acm1, by an Unconventional Proteolytic Mechanism
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  6. Two-Step Mechanism of Cyclin B Degradation Initiated by Proteolytic Cleavage with the 26 S Proteasome in Fish
    Toshinobu Tokumoto, Md. Forhad Hossain, Md. Maisum Sarwar Jyoti, Md Hasan Ali, Md. Babul Hossain, Mrityunjoy Acharjee, Md. Rezanujjaman, Mika Tokumoto · 2020 · Scientific Reports
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  10. The ubiquitin-like modifier FAT10 is degraded by the 20S proteasome in vitro but not in cellulo
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  11. Proteomics Profiling of Chimeric-Truncated Tissue Plasminogen activator Producing- Chinese Hamster Ovary Cells Cultivated in a Chemically Defined Medium Supplemented with Protein Hydrolysates
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  13. The UPS : An Engine that Drives the Cell Cycle
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  14. MDM2 provides TOP2 poison resistance by promoting proteolysis of TOP2βcc in a p53-independent manner
    Jianfeng Shu, Jinni Jiang, Xiaofang Wang, Xuejie Yang, Guofang Zhao, Ting Cai · 2024 · Cell Death and Disease
  15. DNA Methylation in Eukaryotes: Regulation and Function
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  16. Expression and purification of the recombinant full-length retinoblastoma protein and characterisation of its interaction with the oncoprotein HDM2
    Adriana Berenice Rousset-Roman, Yolanda Rebolloso‐Gómez, Vanesa Olivares‐Illana · 2019 · Protein Expression and Purification
  17. Investigating the p21 Ubiquitin-Independent Degron Reveals a Dual Degron Module Regulating p21 Degradation and Function
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  18. A Perspective on Therapeutic Targeting Against Ubiquitin Ligases to Stabilize Tumor Suppressor Proteins
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  19. Inhibiting MDM2 enhances RIPK3-mediated necroptosis and synergizes with immune checkpoint blockade therapy
    Yingxin Wu, Hanyang Yu, Zongxu Zhang, Weihang Xiong, Zexian Zeng, Weili Liu, Hailin Tu, Xin Lin · 2026 · iScience
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  21. JNK1 inhibits transcriptional and pro‐apoptotic activity of TAp63γ
    Ji Chen, Shi H, Jin Qi, Dingyi Liu, Zemin Yang, Chenghua Li · 2015 · FEBS Letters
  22. Ubiquitin-Independent Degradation of Proteins in Proteasomes
    О.А. Бунеева, A. E. Medvedev · 2018 · Biochemistry (Moscow) Supplement Series B Biomedical Chemistry
  23. Ubiquitin‐Independent Mechanisms of Substrate Recognition and Degradation by the Proteasome
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  24. pVHL regulates protein stability of the TCF/LEF transcription factor family via ubiquitin-independent proteasomal degradation
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  25. Cooperation between MDM2 and MDMX in the Regulation of p53
    Jeremy P. Blaydes · 2010 · Molecular biology intelligence unit
  26. The Retinoblastoma Tumour Suppressor
    Alexandra Dirlam, Kay F. Macleod · 2007 · Wiley eBooks
  27. Ubiquitin‐Independent Mechanisms of Substrate Recognition and Degradation by the Proteasome
    Martin A. Hoyt, Philip Coffino · 2007 · Wiley eBooks
  28. Transcriptomic analysis reveals the underlying pro-malignant functions of Gankyrin for colorectal cancer via affecting tumor necrosis factor pathway
    Baojin Xu, Shenglong Li, Wu Lv, Yue Wang, Xiaoyan Li, Lina Zhang, Jie Lin · 2018 · International Journal of Biological Macromolecules
  29. LINE1 insertion into the NACC2 locus disrupts the HDM2 axis and activates lung oncogenic signaling
    Pasano Bojang, Yingshan Wang, Kenneth S. Ramos · 2025 · npj Precision Oncology
  30. MOLECULAR GENETICS OF SOFT TISSUE TUMORS
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  31. DNA Methylation in Eukaryotes: Regulation and Function
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  32. MDM2 (transformed mouse 3T3 cell double minute 2, p53 binding protein)
    MA Villalona-Calero, Wenrui Duan · 2011 · Atlas of Genetics and Cytogenetics in Oncology and Haematology
  33. Interplay of 14-3-3 Family of Proteins with DNA Damage-Regulated Molecules in Checkpoint Control
    Mong‐Hong Lee, Sai‐Ching J. Yeung, Heng-Yin Yang · 2009 · Humana Press eBooks
  34. Retraction Note: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
    Yücel Aydın, Milad Chedid, Srinivas Prabhu Chava, Donkita Danielle Williams, Shuanghu Liu, Curt H. Hagedorn, Suchitra Sumitran–Holgersson, Krzysztof Reiss, Krzysztof Moroz, Hua Lu et al. · 2021 · Scientific Reports · Retracted
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    Gemma S. Cook · 2012 · ORCA Online Research @Cardiff (Cardiff University)
  37. Doctorate School in Molecular Medicine Doctorate Program in Genetics and Molecular Medicine Coordinator: Prof. Lucio Nitsch XXIV Cycle " TBP-1 (TAT BINDING PROTEIN-1) IN THE CONTROL OF CELL PROLIFERATION: FUNCTIONAL RELATIONSHIP WITH THE AKT/PKB SIGNALING PATHWAY"
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  38. mRNA Expression Profiles in Human Lymphoid Progenitor Cell are Modified by High-dose Ionizing Radiation
    Satoru Monzen, Mitsuru Chiba · 2015
  39. The ubiquitin-proteasome system during proteotoxic stress
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  40. Characterization of the Ubiquitin/Nedd8 E3 ligase activity of the Mdm2/MdmX complex
    Rajesh Kumar Singh · 2007 · Kölner Universitäts PublikationsServer (Universität zu Köln)
  41. Regulation of the retinoblastoma tumor suppressor by the novel Ras effector NORE1A.
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  42. Cellular Changes and Effects of Cytokines in the Transformation of Human Mammary Epithelial Cells
    Charlene E. Kan · 2009 · OhioLink ETD Center (Ohio Library and Information Network)
  43. Mechanism and Control of Nuclear-Cytoplasmic Translocation of the Transporter Regulator RS1 Mechanismus und Kontrolle der Translokation der Transporterregulator RS1 zwischen Kern und Zytoplasma
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  44. Impact of Mdm2-p53 on the proteasome assembly and disassembly Role of the ubiquitination of some 19S subunits
    Justine Letienne · 2011 · Repository KITopen (Karlsruhe Institute of Technology)
  45. Investigation of the anti-cancer properties of natural products and synthetic analogues with NQO2 inhibiting potential
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  46. [Expression of hUTP14a in non-small cell lung cancer].
    Chunfeng Zhang, Y Liu, Min Lu, Xiaojuan Du · 2019 · PubMed Central
  47. Characterization of synthetic lethality between Mdm2 overexpression and genotoxic agents and identification of a novel function of the Mdmx oncogene in DNA repair
    Alexia M. Carrillo · 2014
  48. An Integrated Structure-based Approach for the Development of MDM2 inhibitors
    Yi Sheng · 2021 · International Electronic Conference on Cancers (IECC)
  49. The mouse double minute 2 309T>G polymorphism and retinoblastoma risk
    K Sooraj, Sunil Kumar, Amit Kumar, Mandeep S. Bajaj, Jasbir Kaur · 2020 · Saudi Journal of Ophthalmology
  50. Faculty Opinions recommendation of A novel retinoblastoma protein (RB) E3 ubiquitin ligase (NRBE3) promotes RB degradation and is transcriptionally regulated by E2F1 transcription factor.
    Julien Sage · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
  51. MDM2 is a useful diagnostic marker for nasopharyngeal carcinoma
    Cecilia Taverna, Abbas Agaimy, Alessandro Franchi · 2022 · Pathology - Research and Practice
  52. Ubiquitin receptors play redundant roles in the proteasomal degradation of the p53 repressor MDM2
    Alison Sparks, Christopher J. Kelly, Mark K. Saville · 2022 · FEBS Letters
  53. Molecular genetics of soft tissue tumors
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  55. Additional file 4 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  56. Additional file 3 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  57. Additional file 1 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  58. Additional file 22 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  59. Additional file 5 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  60. Additional file 23 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  61. Additional file 21 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Figshare
  62. The effect of Adenovirus E1A on the human immunoproteasome and MHC complex
    Sarah Berhane · 2012 · University of Birmingham Institutional Research Archive (University of Birmingham)
  63. Additional file 20 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  64. Additional file 10 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  65. Additional file 2 of Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
    Sophie Poulet, Meiou Dai, N Wang, Gang Yan, Julien Boudreault, Girija Daliah, Alan Guillevin, Huong Nguyen, Soaad Galal, Suhad Ali et al. · 2024 · Figshare
  66. Additional file 26 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  67. Additional file 11 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  68. Additional file 12 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  69. Additional file 19 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  70. Additional file 16 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  71. Additional file 7 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  72. Additional file 13 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  73. Additional file 27 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  74. Additional file 3 of Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
    Sophie Poulet, Meiou Dai, N Wang, Gang Yan, Julien Boudreault, Girija Daliah, Alan Guillevin, Huong Nguyen, Soaad Galal, Suhad Ali et al. · 2024 · Figshare
  75. Additional file 17 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  76. Additional file 1 of Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
    Sophie Poulet, Meiou Dai, N Wang, Gang Yan, Julien Boudreault, Girija Daliah, Alan Guillevin, Huong Nguyen, Soaad Galal, Suhad Ali et al. · 2024 · Figshare
  77. Additional file 15 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  78. Additional file 28 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  79. Additional file 24 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  80. Additional file 2 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  81. Additional file 8 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  82. Additional file 9 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  83. Additional file 6 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  84. Additional file 18 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  85. Additional file 14 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
  86. Additional file 25 of Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
    Wong, Kim, Abascal, Federico, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Romero, Laura P. et al. · 2023 · Figshare
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