MDM2 Promotes Proteasome-Dependent Ubiquitin-Independent Degradation of Retinoblastoma Protein

Sdek, Patima, Ying, Haoqiang, Chang, Donny L.F., Qiu, Wei, Zheng, Hongwu, Touitou, Robert, Allday, Martin J., Jim Xiao, Zhi-Xiong·2005·Molecular Cell

DOI 10.1016/j.molcel.2005.10.017

Cited by (296)

Items 101–200 of 296

p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2
Lingling Xian, Jing Zhao, Jia Wang, Zhou Fang, Bo Peng, Wenzhang Wang, Xiaona Ji, Long Yu · 2009 · Molecular Biology Reports
Identification of ARIA regulating endothelial apoptosis and angiogenesis by modulating proteasomal degradation of cIAP-1 and cIAP-2
Koji Ikeda, Ritsuko Nakano, Maki Uraoka, Yusuke Nakagawa, Masahiro Koide, Asako Katsume, Keizo Minamino, Eri Yamada, Haruhiko Yamada, Thomas Quertermous et al. · 2009 · Proceedings of the National Academy of Sciences
Stability of the Endosomal Scaffold Protein LAMTOR3 Depends on Heterodimer Assembly and Proteasomal Degradation
Mariana E. G. de Araújo, Taras Stasyk, Nicole Taub, Hannes L. Ebner, Beatrix Fürst, Przemyslaw A. Filipek, Sabine Weys, Michael W. Hess, Herbert H. Lindner, Leopold Kremser et al. · 2013 · Journal of Biological Chemistry
Influence of MDM2 and MDM4 on development and survival in hereditary retinoblastoma
Adriana Helena de Oliveira Reis, Ivna Néria Silva Ribamar de Carvalho, Paula Batista de Sousa Damasceno, Sima Ferman, Evandro Lucena, Jorge S. López‐Camelo, Hector Nicolas Seuánez, Fernando Regla Vargas · 2011 · Pediatric Blood & Cancer
5‐Aza‐2'‐deoxycytidine reactivates gene expression via degradation of pRb pocket proteins
Zhixing Zheng, Lian Li, Xiangyu Liu, Donglai Wang, Bo Tu, Lina Wang, Haiying Wang, Wei‐Guo Zhu · 2011 · The FASEB Journal
Activation of a Novel Ubiquitin-Independent Proteasome Pathway when RNA Polymerase II Encounters a Protein Roadblock
Yi Ban, Chia-Wen Ho, Ren‐Kuo Lin, Y. Lyu, Leroy F. Liu · 2013 · Molecular and Cellular Biology
E2F1-dependent oncogenic addiction of melanoma cells to MDM2
Monique Elise Verhaegen, Aleksandra Chęcińska, MaryBeth Riblett, Shaomeng Wang, Marı́a S. Soengas · 2011 · Oncogene
TBP-1 protects the human oncosuppressor p14ARF from proteasomal degradation
Alessandra Pollice, M. Sepe, V. Villella, Fabio Tolino, Maria Vivó, V. Calabrò, G. La Mantia · 2007 · Oncogene
Id-1 Induces Proteasome-dependent Degradation of the HBX Protein
Ming‐Tat Ling, Yung‐Tuen Chiu, Terence K. Lee, Steve Chin Lung Leung, Maggie K.L. Fung, Xianghong Wang, Kwong‐Fai Wong, Yong Chuan Wong · 2007 · Journal of Molecular Biology
Does control of mutant p53 by Mdm2 complicate cancer therapy?: Figure 1.
Carol L. Prives, Eileen White · 2008 · Genes & Development
Evidence that Proteasome-Dependent Degradation of the Retinoblastoma Protein in Cells Lacking A-Type Lamins Occurs Independently of Gankyrin and MDM2
Ryan Takeo Nitta, Catherine L. Smith, Brian Keith Kennedy · 2007 · PLoS ONE
Smad4 haploinsufficiency: a matter of dosage
Paola Alberici, Claudia Gaspar, Patrick Franken, Marcin M. Gorski, Ingrid de Vries, Rodney John Scott, Ari P. Ristimaki, Lauri A. Aaltonen, Riccardo Fodde · 2008 · PathoGenetics
Effects of MdmX on Mdm2‐mediated downregulation of pRB
Chiharu Uchida, Seiichi Miwa, Tomoyasu Isobe, Kyoko Kitagawa, Takayuki Hattori, Toshiaki Oda, Hideyo Yasuda, Masatoshi Kitagawa · 2006 · FEBS Letters
RETRACTED ARTICLE: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
Yücel Aydın, Milad Chedid, Srinivas Prabhu Chava, Donkita Danielle Williams, Shuanghu Liu, Curt H. Hagedorn, Suchitra Sumitran–Holgersson, Krzysztof Reiss, Krzysztof Moroz, Hua Lu et al. · 2017 · Scientific Reports · Retracted
Abrogation of FBW7α-dependent p53 degradation enhances p53’s function as a tumor suppressor
Vivek Tripathi, Ekjot Kaur, Suhas S. Kharat, Mansoor Hussain, Arun Prasath Damodaran, Swati Kulshrestha, Sagar Sengupta · 2019 · Journal of Biological Chemistry
Mechanisms of TP53 Pathway Inactivation in Embryonic and Somatic Cells—Relevance for Understanding (Germ Cell) Tumorigenesis
Dennis M. Timmerman, Tessa L. Remmers, Sanne Hillenius, Leendert H. J. Looijenga · 2021 · International Journal of Molecular Sciences
Rack1 is essential for corticogenesis by preventing p21-dependent senescence in neural stem cells
Qian Zhu, Liping Chen, Ying Li, Ming-He Huang, Jingyuan Shao, Shen Li, Juanxian Cheng, Haihong Yang, Yan Wu, Jiyan Zhang et al. · 2021 · Cell Reports
The roles of E3 ligases in Hepatocellular carcinoma.
Zongdong Yu, Hong Li, Jie Zhu, Haibiao Wang, Xiaofeng Jin · 2022 · PubMed Central
Proteins Directly Interacting with Mammalian 20S Proteasomal Subunits and Ubiquitin-Independent Proteasomal Degradation
Raúl Sánchez‐Lanzas, José G. Castaño · 2014 · Biomolecules
hHR23B is required for genotoxic-specific activation of p53 and apoptosis
M Kaur, Marius S. Pop, D Shi, Chrystelle Brignone, Steven R. Grossman · 2006 · Oncogene
The expression of COX-2, hTERT, MDM2, LATS2 and S100A2 in different types of non-small cell lung cancer (NSCLC)
Mojca Stražišar, Vid Mlakar, Damjan Glavač · 2009 · Cellular & Molecular Biology Letters
Effect of an hdm-2 antagonist peptide inhibitor on cell cycle progression in p53-deficient H1299 human lung carcinoma cells
Ann VanderBorght, Annemie Valckx, Jacky Van Dun, Thierry Grand‐Perret, Stefanie De Schepper, J Vialard, Michel Janicot, Janine Arts · 2006 · Oncogene
MDMX exerts its oncogenic activity via suppression of retinoblastoma protein
Hong Zhang, Liang Hu, W Qiu, Tiantian Deng, Yong Zhang, Johann S. Bergholz, Z-X Xiao · 2015 · Oncogene
Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma
Parvin Zamani, Maryam Matbou Riahi, Amir Abbas Momtazi‐Borojeni, Khadijeh Jamialahmadi · 2017 · Artificial Cells Nanomedicine and Biotechnology
Gankyrin is a Novel Biomarker for Disease Progression and Prognosis of Patients with Renal Cell Carcinoma
Chao Wang, Yan Li, Chuanmin Chu, Xiang-min Zhang, Jie Ma, Hai Huang, Yu-ning Wang, Tianyu Hong, Jing Zhang, Xiuwu Pan et al. · 2018 · EBioMedicine
High levels of Hdmx promote cell growth in a subset of uveal melanomas.
Job de Lange, Amina F.A.S. Teunisse, Matty Verlaan–de Vries, Kirsten Lodder, Suzanne Lam, Gregorius P. M. Luyten, Federico Bernal, Martine Johanna Jager, Aart G. Jochemsen · 2012 · Europe PMC (PubMed Central)
The ARF Tumor Suppressor Regulates Bone Remodeling and Osteosarcoma Development in Mice
Daniel A. Rauch, Michelle A. Hurchla, John C. Harding, Hongju Deng, Lauren Kelly Shea, Mark C. Eagleton, Stefan Niewiesk, Michael D. Lairmore, David R Piwnica-Worms, Thomas J. Rosol et al. · 2010 · PLoS ONE
p53-Mediated Growth Suppression in Response to Nutlin-3 in Cyclin D1–Transformed Cells Occurs Independently of p21
Charlene E. Kan, John T. Patton, George Robert Stark, Mark W. Jackson · 2007 · Cancer Research
Ras Regulates Rb via NORE1A
Thibaut Barnoud, Howard Donninger, Geoffrey J. Clark · 2015 · Journal of Biological Chemistry
Estrogen-activated MDM2 disrupts mammary tissue architecture through a p53-independent pathway
Nandini Kundu, Angelika Brekman, Jun Yeob Kim, Gu Xiao, Chong Gao, Jill Bargonetti · 2017 · Oncotarget
Destabilization of Rb by human papillomavirus E7 is cell cycle dependent: E2-25K is involved in the proteolysis
Kwang-Jin Oh, Anna Kalinina, Srilata Bagchi · 2009 · Virology
14-3-3γ Inhibition of MDMX-mediated p21 Turnover Independent of p53
Jun‐Ho Lee, Hua Lu · 2010 · Journal of Biological Chemistry
The Mdm2 Ubiquitin Ligase Enhances Transcriptional Activity of Human Papillomavirus E2
Noor Gammoh, D. Gardiol, P. Massimi, L. Banks · 2008 · Journal of Virology
Alternative UPS drug targets upstream the 26S proteasome
Roland Hjerpe, Manuel S. Rodríguez · 2007 · The International Journal of Biochemistry & Cell Biology
A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM–p53 signaling
Yifan Wang, Qikai Xu, Laura Magill Sack, Chanhee Kang, Stephen Joseph Elledge · 2016 · Genes & Development
The G 1 -S transition is promoted by Rb degradation via the E3 ligase UBR5
Shuyuan Zhang, Lucas Fuentes Valenzuela, Evgeny A. Zatulovskiy, Lise Mangiante, Christina N. Curtis, Jan Marcel Skotheim · 2024 · Science Advances
MDM2-Mediated Degradation of p14ARF: A Novel Mechanism to Control ARF Levels in Cancer Cells
Maria Vivo, Maria Matarese, Maria Sepe, Rosaria Di Martino, Luisa Festa, Viola Calabrò, Girolama La Mantia, Alessandra Pollice · 2015 · PLoS ONE
Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Kim Wong, Federico Abascal, Latasha Ludwig, Heike Aupperle‐Lellbach, Julia Maria Grassinger, Colin W. Wright, Simon J. Allison, Emma Pinder, Roger M. Phillips, Laura P. Romero et al. · 2023 · Genome biology
Epstein-Barr Virus Nuclear Antigen 3A Promotes Cellular Proliferation by Repression of the Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1
Melissa L. Tursiella, Emily Bowman, Keith C. Wanzeck, Robert E. Throm, Jason Liao, Junjia Zhu, Clare E. Sample · 2014 · PLoS Pathogens
Proteasome and cancer.
B. Catalgol · 2012 · Progress in Molecular Biology and Translational Science
A paternal signal induces endosperm proliferation upon fertilization in Arabidopsis
Sara Simonini, Stefano Bencivenga, Ueli Grossniklaus · 2024 · Science
Direct proteasome binding and subsequent degradation of unspliced XBP‐1 prevent its intracellular aggregation
Ami Navon, Ariel Gatushkin, Lior Zelcbuch, Shimon Shteingart, Marganit Farago, Rivka Hadar, Boaz Tirosh · 2009 · FEBS Letters
Constitutive and induced functions of the p53 gene
Andrei O. Zheltukhin, Peter M. Chumakov · 2010 · Biochemistry (Moscow)
Experimental Therapy of Advanced Breast Cancer: Targeting NFAT1–MDM2–p53 Pathway
Jiang‐Jiang Qin, Wei Wang, Ruiwen Zhang · 2017 · Progress in molecular biology and translational science
Distinct selective forces and Neanderthal introgression shaped genetic diversity at genes involved in neurodevelopmental disorders
Mozzi, Alessandra, Forni, Diego, Cagliani, Rachele, Pozzoli, Uberto, Clerici, Mario, Sironi, Manuela · 2017 · Scientific Reports
Downregulation of cyclin D1 sensitizes cancer cells to MDM2 antagonist Nutlin-3
Yang, Peipei, Chen, Weicai, Li, Xuhui, Eilers, Grant, He, Quan, Liu, Lili, Wu, Yeqing, Wu, Yuehong, Yu, Wei, Fletcher, Jonathan A. et al. · 2016 · Oncotarget
Protecting the genome from mdm2 and mdmx
Melo, A. N., Eischen, C. M. · 2012 · Genes & Cancer
The role of the NORE1A tumor suppressor in Oncogene-Induced Senescence
Thibaut Barnoud, Marianne Schmidt, Howard Donninger, Geoffrey J. Clark · 2017 · Cancer Letters
Ubiquitin-Regulated Cell Proliferation and Cancer
Beatriz Pérez‐Benavente, Alihamze Fathinajafabadi, Rosa Farrás · 2020 · Advances in experimental medicine and biology
MDM2 regulates RB levels during genotoxic stress
Jesús Hernández‐Monge, Mayra Martínez‐Sánchez, Adriana Berenice Rousset-Roman, Ixaura Medina‐Medina, Vanesa Olivares‐Illana · 2020 · EMBO Reports
Genome-wide in vivo CRISPR screen identifies TGFβ3 as actionable biomarker of palbociclib resistance in triple negative breast cancer
Sophie Poulet, Meiou Dai, Ni Wang, Gang Yan, Julien Boudreault, Girija Daliah, Alan Guillevin, Huong Nguyen, Soaad Galal, Suhad Ali et al. · 2024 · Molecular Cancer
The Homeodomain Transcription Factor Hoxa2 Interacts with and Promotes the Proteasomal Degradation of the E3 Ubiquitin Protein Ligase RCHY1
Isabelle Bergiers, Laure Bridoux, Nathan Nguyen, Jean‐Claude Twizere, René Rezsöhazy · 2013 · PLoS ONE
MDM2-Mediated Ubiquitination of RXRβ Contributes to Mitochondrial Damage and Related Inflammation in Atherosclerosis
Yi Zeng, Ji Cao, Chunxia Li, Chunyan Wang, Ruoman Wu, Xiaole Xu · 2022 · International Journal of Molecular Sciences
Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy
Wei Du, Yong Yi, Haibo Zhang, Johann S. Bergholz, Junfeng Wu, Haoqiang Ying, Yujun Zhang, Zhi‐Xiong Jim Xiao · 2013 · PLoS ONE
Quantitative proteome analysis of the 20S proteasome of apoptotic Jurkat T cells
Frank Schmidt, Burkhardt Dahlmann, Hanne Kolsrud Hustoft, Christian Jeffrey Koehler, Margarita Strozynski, Alexander Kloß, Ursula Zimny‐Arndt, Peter Roman Jungblut, Bernd Thiede · 2010 · Amino Acids
Paradoxical Instability–Activity Relationship Defines a Novel Regulatory Pathway for Retinoblastoma Proteins
Pankaj Acharya, Nitin Raj, Martin S. Buckley, Liang Zhang, Stephanie Duperon, Geoffrey L. Williams, R. William Henry, David N. Arnosti · 2010 · Molecular Biology of the Cell
Advanced Glycation End Products Increase MDM2 Expression via Transcription Factor KLF5
Pu Wang, Yucheng Lu, Yuan Fei Li, Lan Wang, Shao Chin Lee · 2018 · Journal of Diabetes Research
MDM2 as a Rational Target for Intervention in CDK4/6 Inhibitor Resistant, Hormone Receptor Positive Breast Cancer
Neil Portman, Julia Chen, Elgene Lim · 2021 · Frontiers in Oncology
Signaling Pathways Involved in Megakaryocyte‐Mediated Proliferation of Osteoblast Lineage Cells
Ying‐Hua Cheng, Drew A. Streicher, David L. Waning, Brahmananda Reddy Chitteti, Rita L. Gerard-O’Riley, Mark C. Horowitz, Joseph P. Bidwell, Fredrick M. Pavalko, Edward F. Srour, Lindsey D. Mayo et al. · 2014 · Journal of Cellular Physiology
Human U3 protein14a is a novel type ubiquitin ligase that binds RB and promotes RB degradation depending on a leucine-rich region
Huijiao Liu, Jiangnan Wang, Yun Liu, Lelin Hu, Chunfeng Zhang, Baocai Xing, Xiaojuan Du · 2018 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
MDM2 Overexpression, Activation of Signaling Networks, and Cell Proliferation
Swati Palit Deb, Shilpa Singh, Sumitra Deb · 2014 · Sub-cellular biochemistry/Subcellular biochemistry
Heterozygous p53V172F mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53
X Xie, Guillermina Lozano, Zahid Hussain Siddik · 2016 · Oncogene
Ubiquitin-independent protein degradation in proteasomes
О.А. Бунеева, A. E. Medvedev · 2018 · Biomeditsinskaya Khimiya
Functional dissection of the N-terminal degron of human thymidylate synthase
Sandra P. Melo, Asami Yoshida, Franklin G. Berger · 2010 · Biochemical Journal
ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2
Donny L.F. Chang, Wei Qiu, Haoqiang Ying, Tracy Zhang, C. Y. Chen, Z-X J Xiao · 2007 · Oncogene
Retinoblastoma protein co-purifies with proteasomal insulin-degrading enzyme: Implications for cell proliferation control
Razvan T. Radulescu, William C. Duckworth, Jennifer L. Levy, Janet Fawcett · 2010 · Biochemical and Biophysical Research Communications
FRMD8 targets both CDK4 activation and RB degradation to suppress colon cancer growth
Miao Yu, Weijie Wu, Yi Sun, Haoyi Yan, Lei Zhang, Zhenbin Wang, Yuqing Gong, Tianzhuo Wang, Qianchen Li, Jiagui Song et al. · 2023 · Cell Reports
Nuclear Beclin 1 Destabilizes Retinoblastoma Protein to Promote Cell Cycle Progression and Colorectal Cancer Growth
Yang Pan, Zhiqiang Zhao, Juan Li, Jinsong Li, Yue Luo, Weiyuxin Li, Wanbang You, Yujun Zhang, Zhonghan Li, Jian Yang et al. · 2022 · Cancers
Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression
Yulan Huang, Yuan Gao, Zhenghong Lin, Hongming Miao · 2024 · Genes & Diseases
Integrated Stability and Activity Control of the Drosophila Rbf1 Retinoblastoma Protein
Liang Zhang, Yiliang Wei, Irina Pushel, Karolin Heinze, Jared S. Elenbaas, R. William Henry, David N. Arnosti · 2014 · Journal of Biological Chemistry
The Role of p53 in Nanoparticle-Based Therapy for Cancer
Olga Klaudia Szewczyk-Roszczenko, Nickolai A. Barlev · 2023 · Cells
Regulation of Retinoblastoma Protein (Rb) by p21 Is Critical for Adaptation to Massive Small Bowel Resection
Jennifer A. Leinicke, Shannon W. Longshore, Derek S. Wakeman, Jun Guo, Brad W. Warner · 2011 · Journal of Gastrointestinal Surgery
Proline-mediated Proteasomal Degradation of the Prostate-specific Tumor Suppressor NKX3.1
Varsha Rao, Bin Guan, Laura N. Mutton, Charles J. Bieberich · 2012 · Journal of Biological Chemistry
Screening E3 Substrates Using a Live Phage Display Library
Zhengguang Guo, Xiaorong Wang, Hui‐Hua Li, Youhe Gao · 2013 · PLoS ONE
Mass spectrometric analysis of affinity-purified proteasomes from the human myelogenous leukemia K562 cell line
Т. О. Артамонова, Mikhail A. Khodorkovskii, Цимоха Анна Сергеевна · 2014 · Russian Journal of Bioorganic Chemistry
MDM2/MDMX: Master negative regulators for p53 and RB
Linshan Hu, Haibo Zhang, Johann S. Bergholz, Shengnan Sun, Zhi‐Xiong Jim Xiao · 2016 · Molecular & Cellular Oncology
Coiled-coil domain containing 3 suppresses breast cancer growth by protecting p53 from proteasome-mediated degradation
Caiyue Li, Hyemin Lee, Ji Hoon Jung, Yi-Wei Zhang, Jieqiong Wang, Chang Liu, Roger L. Sheffmaker, Allyson M. Segall, Shelya X. Zeng, Hua Lu · 2022 · Oncogene
NORE1A Regulates MDM2 Via β-TrCP
M. Schmidt, Diego Francesco Calvisi, Geoffrey Clark · 2016 · Cancers
Targeted Neoadjuvant Therapies in HR+/HER2−Breast Cancers: Challenges for Improving pCR
Nandini Dey, Jennifer Carlson Aske, Pradip K.R De · 2021 · Cancers
The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation
Herui Wang, Bin Li, Kulsum Asha, Ryan L. Pangilinan, Asha Thuraisamy, Harman Chopra, Susumu Rokudai, Yong Yu, Carol L. Prives, Yan Yu Zhu · 2021 · Journal of Biological Chemistry
TTC39B destabilizes retinoblastoma protein promoting hepatic lipogenesis in a sex-specific fashion
Joanne Hsieh, Matthew M. Molusky, Kristin M. McCabe, Panagiotis Fotakis, Tong Xiao, Liana Tascau, Lars Zeana-Schliep, Paul A DaSilva-Jardine, Alan R. Tall · 2021 · Journal of Hepatology
Gankyrin: At the crossroads of cancer diagnosis, disease prognosis, and development of efficient cancer therapeutics
Dharmendra Kashyap, Nidhi Varshney, Hamendra Singh Parmar, Hem Chandra Jha · 2021 · Advances in Cancer Biology - Metastasis
MDM2 inhibition is synthetic lethal with PTEN loss in colorectal cancer cells via the p53-dependent mechanism
Guowen Ren, Eun Ju Yang, Shishi Tao, Pui Kei Mou, Yue Pu, Lijie Chen, Joong Sup Shim · 2023 · International Journal of Biological Sciences
Genetic screening and functional analysis of CASP 9 mutations in a Chinese cohort with neural tube defects
Xiao‐Zhen Liu, Qin Zhang, Qian Jiang, Baoling Bai, Xiaojuan Du, Fang Wang, Li‐Hua Wu, Xiao‐Lin Lu, Yihua Bao, Huili Li et al. · 2018 · CNS Neuroscience & Therapeutics
Cullin3/ KCTD 5 induces monoubiquitination of ΔNp63α and impairs its activity
Hanbing He, Yougong Peng, Shijie Fan, Yonglong Chen, Xuan Zheng, Chenghua Li · 2018 · FEBS Letters
Combined treatment of human multiple myeloma cells with bortezomib and doxorubicin alters the interactome of 20S proteasomes
Alexey G. Mittenberg, Valeria O. Kuzyk, Sergey Shabelnikov, Daria P. Gorbach, Alla N. Shatrova, Olga Fedorova, Nickolai A. Barlev · 2018 · Cell Cycle
State of the Art of Pharmacological Activators of p53 in Ocular Malignancies
Fabio Casciano, Enrico Zauli, Massimo Busin, Lorenzo Caruso, Saleh Al-Mesfer, Samar A. Al-Swailem, Giorgio Zauli, Angeli Christy Yu · 2023 · Cancers
Deregulation of p53 and RB Transcriptional Control Leads to Overexpression of DNA Methyltransferases in Lung Cancer
Yen‐An Tang, Yo-Ting Tsai, Ruo-Kai Lin, Han‐Shui Hsu, Chih-Yi Chen, Yi‐Ching Wang · 2014 · Journal of Cancer Research and Practice
Aberrant Proliferation in CXCR7+ Endothelial Cells via Degradation of the Retinoblastoma Protein
Jennifer E. Totonchy, Jessica M. Osborn, Sara Botto, Lisa Clepper, Ashlee V. Moses · 2013 · PLoS ONE
Correction: Rapamycin Inhibits IGF-1-Mediated Up-Regulation of MDM2 and Sensitizes Cancer Cells to Chemotherapy
Wei Dong Du, Yong Yi, Haibo Zhang, Johann S. Bergholz, Junfeng Wu, Haoqiang Ying, Yujun Zhang, Zhi‐Xiong Jim Xiao · 2013 · PLoS ONE
NIR promotes progression of colorectal cancer through regulating RB
Yuan Li, Ling Wang, Xiaofeng Liu, Chunfeng Zhang, Xiaojuan Du, Baocai Xing · 2020 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation
Erica M. Walsh, Mengmeng Niu, Johann S. Bergholz, Zhi‐Xiong Jim Xiao · 2015 · Biochemical and Biophysical Research Communications
The Evolutionarily Conserved C-terminal Domains in the Mammalian Retinoblastoma Tumor Suppressor Family Serve as Dual Regulators of Protein Stability and Transcriptional Potency
Satyaki Sengupta, Raj Lingnurkar, Timothy S. Carey, Monica M. Pomaville, Parimal Kar, Michael Feig, CATHERINE A. WILSON, Jason G. Knott, David N. Arnosti, R. William Henry · 2015 · Journal of Biological Chemistry
The C-Terminus of the PSMA3 Proteasome Subunit Preferentially Traps Intrinsically Disordered Proteins for Degradation
Assaf Biran, Nadav Myers, Shirel Steinberger, Julia Adler, Marianna Riutin, Karin Broennimann, Nina Bacher Reuven, Yosef Shaul · 2022 · Cells
CDK7-dependent transcriptional addiction in bone and soft tissue sarcomas: Present and Future
Jin Yuan, Xiaoyang Li, Shengji Yu · 2022 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Ubiquitin E3 ligases controlling p53 stability
Seong Won Lee, Min Woo Seong, Young Joo Jeon, Chin Ha Chung · 2012 · Animal Cells and Systems
The C-terminal Residues of Saccharomyces cerevisiae Mec1 Are Required for Its Localization, Stability, and Function
L. DaSilva, Samantha A Pillon, J. Genereaux, M. Davey, G. Gloor, J. Karagiannis, C. Brandl · 2013 · G3: Genes, Genomes, Genetics
Mdm2 Plays a Positive Role as an Effector of p53-Dependent Responses
Luciana E. Giono, James J. Manfredi · 2007 · Cell Cycle
Gene expression profiling analysis of the role of miR-22 in clear cell ovarian cancer
Y. B. ZHEN, X. L. GUO, Bianling Xu, Haomin Zhao, Changyan Xu · 2016 · Neoplasma
Human U3 protein 14a plays an anti-apoptotic role in cancer cells
Teng Ma, Chenxi Lu, Yafei Guo, Chunfeng Zhang, Xiaojuan Du · 2017 · Biological Chemistry