The Structure of SOCS3 Reveals the Basis of the Extended SH2 Domain Function and Identifies an Unstructured Insertion That Regulates Stability
Babon, Jeffrey J., McManus, Edward J., Yao, Shenggen, DeSouza, David P., Mielke, Lisa A., Sprigg, Naomi S., Willson, Tracy A., Hilton, Douglas J. +4 more·2006·Molecular Cell
Cited by (162)
Items 101–162 of 162
- Tumor necrosis factor‐α augments lipopolysaccharide‐induced suppressor of cytokine signalling 3 (SOCS‐3) protein expression by preventing the degradationJargalsaikhan Dagvadorj, Yoshikazu Naiki, Gantsetseg Tumurkhuu, Abu Shadat Mohammod Noman, Imtiaz Iftakhar-E-Khuda, Takayuki Komatsu, Naoki Koide, Tomoaki Yoshida, Takashi Yokochi · 2009 · Immunology
- Cortical Layer Inversion and Deregulation of Reelin Signaling in the Absence of SOCS6 and SOCS7Isobel D. Lawrenson, Danielle L. Krebs, Edmond M. Linossi, Jian‐Guo Zhang, Tamara J. McLennan, Caitlin Collin, Helen M. McRae, Tatiana B. Kolesnik, Katrina SY Koh, Joanne Maria Britto et al. · 2015 · Cerebral Cortex
- Detection and Quantification of Protein–Protein Interactions by Far-Western BlottingJoshua A. Jadwin, Bruce J. Mayer, Kazuya Machida · 2015 · Methods in molecular biology
- Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2Hiu Kiu, Christopher J. Greenhalgh, Anne L. Thaus, Douglas J. Hilton, Nicos Anthony Nicola, Warren S. Alexander, Andrew Warwick Roberts · 2009 · Growth Factors
- SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinaseTizong Miao, Dongsheng Wu, Yi Zhang, Xuenong Bo, Fang Xiao, Xinyu Zhang, Charalambos Magoulas, Maria Cristina Subang, Ping Wang, P. M. Richardson · 2007 · Molecular and Cellular Neuroscience
- Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNKRhiannon Morris, Yaoyuan Zhang, Julia I. Ellyard, Carola G. Vinuesa, James M. Murphy, Artem Laktyushin, Nadia J. Kershaw, Jeffrey J. Babon · 2021 · Nature Communications
- Suppressor of cytokine signaling 6 in cancer development and therapy: Deciphering its emerging and suppressive rolesZhi Ping Yang, Shigao Huang, Lina Zhao · 2022 · Cytokine & Growth Factor Reviews
- Suppressor of Cytokine Signaling 3 Promotes Bone Marrow Cells to Differentiate into CD8+ T Lymphocytes in Lung Tissue via Up-Regulating Notch1 ExpressionZhuohan Zhang, Bin Zeng, Zhiqian Zhang, Guohui Jiao, Haijie Li, Zhizi Jing, Jiangbo Ouyang, Xin Yuan, Limin Chai, Yongzhe Che et al. · 2009 · Cancer Research
- The pluripotency transcription factor Kruppel-like factor 4 is strongly expressed in intratubular germ cell neoplasia unclassified and seminomaMaren Godmann, Isabella Gashaw, Katja Eildermann, Stefan Schweyer, Martin Bergmann, Rolf Inge Skotheim, Rüdiger Behr · 2009 · Molecular Human Reproduction
- Is there a role for prostanoid-mediated inhibition of IL-6trans-signalling in the management of pulmonary arterial hypertension?Gillian A. Durham, Timothy M. Palmer · 2019 · Biochemical Society Transactions
- Molecular characterization of nine suppressors of cytokine signaling (SOCS) genes from yellow catfish Pelteobagrus fulvidraco and their changes in mRNA expression to dietary carbohydrate levelsHan-Mei Ye, Tao Zhao, Li‐Xiang Wu, Jie Cheng, Xiao-Ying Tan · 2018 · Fish & Shellfish Immunology
- The role of microtubule‐associated protein 1S in SOCS3 regulation of IL‐6 signalingTingting Zou, Lu Ouyang, Lü Chen, Wei Dong, Hong Qiao, Yingle Liu, Yipeng Qi · 2008 · FEBS Letters
- A yeast two-hybrid system reconstituting substrate recognition of the von Hippel-Lindau tumor suppressor proteinClaudia Pfander, Katja Knauth, Silvia Dambacher, Alexander Buchberger · 2007 · Nucleic Acids Research
- New insight into the role of SOCS family in immune regulation and autoimmune pathogenesisShiyi Liu, Mingwei Wang, Liangjie Xu, Daihua Deng, Liwei Lu, Jie Tian, Dongmei Zhou, Ke Rui · 2025 · Journal of Advanced Research
- Molecular signaling involving intrinsically disordered proteins in prostate cancerDaniela Marasco, Anna Russo, Sara La Manna, Ettore Novellino, Anna Maria Malfitano · 2016 · Asian Journal of Andrology
- The Negative Regulation of JAK/STAT SignalingJames M. Murphy, Gillian M. Tannahill, Douglas J. Hilton, Christopher J. Greenhalgh · 2010 · Elsevier eBooks
- Chapter 3 Role of SOCS in Allergic and Innate Immune ResponsesSuzanne L. Cassel, Paul B. Rothman · 2009 · Advances in immunology
- Porcine reproductive and respiratory syndrome virus increases SOCS3 production via activation of p38/AP-1 signaling pathway to promote viral replicationXuegang Luo, Xinxin Chen, Songlin Qiao, Rui Li, Qingxia Lu, Rui Geng, Li Wang, En‐Min Zhou, Gaiping Zhang · 2021 · Veterinary Microbiology
- Molecular characterization and immunoregulatory analysis of suppressors of cytokine signaling 1 (SOCS1) in black rockfish, Sebastes schlegeliGuanghua Wang, Wenqing Liu, Changbiao Wang, Jingjing Wang, Hongmei Liu, Dongfang Hao, Min Zhang · 2022 · Developmental & Comparative Immunology
- Modular Protein Interaction Domains in Cellular CommunicationTony J. Pawson, Piers Nash · 2010 · Elsevier eBooks
- Dynamic IL-6R/STAT3 signaling leads to heterogeneity of metabolic phenotype in pancreatic ductal adenocarcinoma cellsBlaszczak, Wiktoria, White, Bobby, Monterisi, Stefania, Swietach, Pawel · 2024 · Cell Reports
- SOCS3: An Immunological Biomarker Offering Potential Therapeutic Targets for Malignant TumorsYan Zhang, Meiling Chu, Meina Ye, Yulian Yin, Hongfeng Chen · 2025 · Biological Procedures Online
- Grasp a pTyr-Peptide by Its SOCSToshio Hirano, Masaaki Murakami · 2006 · Developmental Cell
- SH2 Domain Structures and InteractionsPiraveen Gopalasingam, Lee Quill, Mark Jeeves, Michael Overduin · 2015 · Springer eBooks
- Molecular characterization and expression analysis of suppressors of cytokine signalling from golden pompano ( Trachinotus ovatus )Ruifeng Qiao, Xie Yeyang, Yuhao Liu, Shuangshuang Gao, Xiaoxia Li, Jiang Li, Peng Zhu, Youchuan Wei, Zhitao Qi · 2021 · Aquaculture Research
- Dynamic expression of the suppressor of cytokine signaling-3 and cytokines in the cerebral basilar artery of rats with subarachnoid hemorrhage, and the effect of acetylcholineJinning Song, Ming Zhang, Li Y, Min Li, Jiyang An, Mao-Feng Cheng, Xiaoye Guo · 2014 · Acta Neurochirurgica
- Unfolding Mechanisms and Conformational Stability of the Dimeric Endophilin N-BAR DomainRui Jin, Michael J. Grasso, Mingyang Zhou, Ronen Marmorstein, Tobias Baumgart · 2021 · ACS Omega
- Regulation of mIκBNS stability through PEST-mediated degradation by proteasomeKoog Chan Park, Jiyeong Jeong, Keun Il Kim · 2014 · Biochemical and Biophysical Research Communications
- Erythropoietin Receptor Structural DomainsQingxin Li, CongBao Kang · 2017 · Vitamins and hormones
- Unveiling the pathological functions of SOCS in colorectal cancer: Current concepts and future perspectivesYuhan Wang, Sha Wu, ZhiHui Song, Yang Yu, Yaling Li, Jun Li · 2024 · Pathology - Research and Practice
- Comparisons of SOCS mRNA and protein levels in Xenopus provide insights into optic nerve regenerative successRupa Priscilla, Ben G. Szaro · 2018 · Brain Research
- Expression and Production of SH2 Domain ProteinsBernard A. Liu, Mari Ogiue-Ikeda, Kazuya Machida · 2017 · Methods in molecular biology
- The JAK–STAT–SOCS Signaling CascadeJane M. Murphy, Jeffrey J. Babon, Nicos Anthony Nicola, Sandra E. Nicholson · 2015 · Elsevier eBooks
- Purification of SOCS (Suppressor of Cytokine Signaling) SH2 Domains for Structural and Functional StudiesNicholas P. D. Liau, Artem Laktyushin, Jeffrey J. Babon · 2017 · Methods in molecular biology
- Detection of Endogenous SOCS1 and SOCS3 Proteins by Immunoprecipitation and Western Blot AnalysisJian‐Guo Zhang, Sandra E. Nicholson · 2012 · Methods in molecular biology
- The Ability of SOCS1 to Cross-Regulate GM-CSF Signaling is Dose DependentGrace M. Bidgood, Narelle Keating, Lizeth G. Meza Guzman, Kunlun Li, Evelyn Leong, Andrew J. Kueh, Jeffrey J. Babon, Colin Hockings, Karen Doggett, Sandra E. Nicholson · 2025 · Journal of Interferon & Cytokine Research
- Receptor engineering constitutes feedback control and robustness of IL-23R signaling and highlights importance of intracellular cytokine receptor signaling motifsLeorina Kashtanjeva, Christin Ruhland, F. C. Horstmeier, Felix Thives-Kurenbach, Julia Ettich, Giacomo Padrini, Sophie Streuber, Jürgen Scheller, Anna Dittrich, Doreen Manuela Floss · 2026 · Cell Communication and Signaling
- The Roles of SOCS in Teleost Immunity: Cytokine Regulation and Host DefenseY H Zhang, Li Yang, Xiuying Cui, Feng Gao, Yanjing Zhao, Xianghui Kong · 2026 · Reviews in Aquaculture
- Molecular cloning and characterization of SOCS2 from the mealworm beetle Tenebrio molitorBo Bae Kim, Bharat Bhusan Patnaik, Yong Hun Jo, In Seok Bang · 2019 · Entomological Research
- Efficient Human Cytomegalovirus Replication in Primary Endothelial Cells Is SOCS3 DependentOlmo Sonzogni, Anne‐Laure Millard, Aline Taveira, Mårten K. J. Schneider, Duo Li, Roberto F. Speck, Gerburg M. Wulf, Nicolas Johannes Mueller · 2019 · Intervirology
- Far-Western BlottingBiji T. Kurien · 2021 · Techniques in life science and biomedicine for the non-expert
- SOCS Proteins and Cytokine Signalling: The many Faces of the SOCS BoxJulie Piessevaux · 2008 · Ghent University Academic Bibliography (Ghent University)
- Helical Assemblies and SH DomainsNatalya A. Kurochkina, Michael J. Iadarola · 2015 · Springer eBooks
- LOSS OF GPRC5A ENHANCES SURVIVAL IN NORMAL AND MALIGNANT LUNG EPITHELIAL CELLS BY ELICITING PERSISTENT STAT3 ACTIVATION INDUCED BY AUTOCRINE LIFYulong Chen · 2010 · Digital Commons-TMC (Texas Medical Center)
- Negative Regulation of Haematopoiesis: Role of Inhibitory AdaptorsLaura Velazquez · 2012 · InTech eBooks
- Expression des SOCS-1 et SOCS-3 par les lymphocytes T humains en réponse à des cytokines immuno-modulatricesLama El‐Khoury · 2009
- The Role of SOCS3 Signaling in Ulcerative Colitis and Ulcerative Colitis-related CarcinogenesisYi Li · 2012 · EUR Research Repository (Erasmus University Rotterdam)
- SOCS-proteiner i laksens antivirale forsvar - til nytte for virus eller vert?Lisbeth Lindenskov Joensen · 2014
- Signalling and crosstalk in cytokine pathways: mathematical modelling and quantitative analysisShabnam Khatibi · 2016 · Minerva Access (University of Melbourne)
- A molecular dissection of neuroinflammation in ovine Batten diseaseZhe Chen · 2016 · Lincoln University Research Archive (Lincoln University)
- Insights into BTB-Cul3 Ubiquitin Ligases from the Structures of SPOP-Substrate ComplexesMin Zhuang · 2009
- Nutrition in IBDZubin Grover, Peter J. Lewindon · 2019 · Springer eBooks
- Cytokine and COVID19: A Literature ReviewSreekiran. Cv, Shatabdi Dey · 2020 · International Journal of Trend in Scientific Research and Development
- The JAK–STAT–SOCS Signaling CascadeJane M. Murphy, Jeffrey J. Babon, Nicos Anthony Nicola, Sandra E. Nicholson · 2016 · Elsevier eBooks
- Data from Antigen Presentation by Dendritic Cells in Tumors Is Disrupted by Altered Metabolism that Involves Pyruvate Kinase M2 and Its Interaction with SOCS3Zhuohan Zhang, Qiaofei Liu, Yongzhe Che, Xin Yuan, Lingyun Dai, Bin Zeng, Guohui Jiao, Yin Zhang, Xue Wu, Yinyan Yu et al. · 2023
- Role of Socs1 variants and Socs3 expression levels in interleukins production in asthmaHanya Bachay Makttoof, Shereen Al-Ali, Hadi Lazim Alabadi · 2025 · Asia-Pacific Journal of Molecular Biology and Biotechnology
- Recent Advances in Understanding the Role of PEST Sequence- Containing Proteins in Retinal NeovascularizationYuxi Du, Yalong Dang · 2025 · Current Drug Targets
- Identification et caractérisation d'une nouvelle forme de défaut partiel récessif héréditaire en JAK1 chez l'hommeValentine Jeanne-Julien · 2019
- Comprendre et cibler la molécule intracellulaire "CISH" dans les cellules Natural Killer : une stratégie pour optimiser les traitements en immunothérapiesPierre-Louis Bernard · 2023 · theses.fr (ABES)
- Protein design to broadly reprogram engineered T cell functionScott E. Boyken, Sean Merillat, Robert A. Langan, Howell F. Moffett, Brian Coventry, Françoise Haeseleer, Kevin G. Haworth, Inna Goreshnik, Joseph DeSautelle, John Chukinas et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Tyrosine phosphorylation and dimerization cooperatively activate NAMPT to enable NAD+ synthesis in cancerJohnvesly Basappa, Cosimo Lobello, Anneliese M. Faustino, Cristina Uribe‐Alvarez, David Rushmore, Niel Sen, Li Wang, Andrey Efimov, Kathy Qi Cai, Jaime Laurel Schneider et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
- Substrate specificity of receptor tyrosine kinases is critical for selective signalingMaria L Pineda · 2012 · Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory)