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RecQ Helicase, Sgs1, and XPF Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules during Meiotic Recombination
Open accessAbstract
Summary Saccharomyces cerevisiae RecQ helicase, Sgs1, and XPF-family endonuclease, Mus81-Mms4, are implicated in processing joint molecule (JM) recombination intermediates. We show that cells lacking either enzyme frequently experience chromosome segregation problems during meiosis and when both enzymes are absent attempted segregation fails catastrophically. In all cases, segregation appears to be impeded by unresolved JMs. Analysis of the DNA events of recombination indicates that Sgs1 limits aberrant JM structures that result from secondary strand-invasion events and often require Mus81-Mms4 for their normal resolution. Aberrant JMs contain high levels of single Holliday junctions and include intersister JMs, multi-chromatid JMs comprising three and four chromatids, and newly identified recombinant JMs containing two chromatids, one of which has undergone crossing-over. Despite persistent JMs in sgs1 mms4 double mutants, crossover and noncrossover products still form at high levels. We conclude that Sgs1 and Mus81-Mms4 collaborate to eliminate aberrant JMs whereas as-yet-unidentified enzymes process normal JMs.
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Cited by
Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis
Matos, J., Blanco, M. G., Maslen, S., Skehel, J. M., & West, S. C. (2011) · Cell · doi:10.1016/j.cell.2011.08.032 · Cited by 294
FIGL1 and its novel partner FLIP form a conserved complex that regulates homologous recombination
Fernandes, J. B., Duhamel, M., Seguéla-Arnaud, M., Froger, N., Girard, C., Choinard, S., Solier, V., De Winne, N., De Jaeger, G., Gevaert, K., et al. (2018) · PLOS Genetics · doi:10.1371/journal.pgen.1007317 · Cited by 116
“Thus, we favor the hypothesis in which the absence of FLIP and FIGL1 leads to excessive and/or late activity of DMC1/RAD51, generating aberrant joint molecules such as multi-chromatid joint molecules [49,50].”
Background
Metadata
- Authors
- Oh, S. D., Lao, J. P., Taylor, A. F., Smith, G. R., & Hunter, N.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 31
- Issue
- 3
- Pages
- 324-336
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2019661860
- Cited by
- 171
- References
- 0
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: RecQ Helicase, Sgs1, and XPF Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules during Meiotic Recombination. https://app.cochat.ai/papers/10.1016/j.molcel.2008.07.006
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- Oh, S. D., Lao, J. P., Taylor, A. F., Smith, G. R., & Hunter, N. (2008). RecQ Helicase, Sgs1, and XPF Family Endonuclease, Mus81-Mms4, Resolve Aberrant Joint Molecules during Meiotic Recombination. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.07.006
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