The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis
Open accessAbstract
SUMMARY The efficient and timely resolution of DNA recombination intermediates is essential for bipolar chromosome segregation. Here, we show that the specialized chromosome segregation patterns of meiosis and mitosis, which require the coordination of recombination with cell-cycle progression, are achieved by regulating the timing of activation of two crossover-promoting endonucleases. In yeast meiosis, Mus81-Mms4 and Yen1 are controlled by phosphorylation events that lead to their sequential activation. Mus81-Mms4 is hyperactivated by Cdc5-mediated phosphorylation in meiosis I, generating the crossovers necessary for chromosome segregation. Yen1 is also tightly regulated and is activated in meiosis II to resolve persistent Holliday junctions. In yeast and human mitotic cells, a similar regulatory network restrains these nuclease activities until mitosis, biasing the outcome of recombination toward non-crossover products while also ensuring the elimination of any persistent joint molecules. Mitotic regulation thereby facilitates chromosome segregation while limiting the potential for loss of heterozygosity and sister-chromatid exchanges.
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Causes and consequences of replication stress
Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079
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Metadata
- Authors
- Matos, J., Blanco, M. G., Maslen, S., Skehel, J. M., & West, S. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 147
- Issue
- 1
- Pages
- 158-172
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2103972950
- Cited by
- 294
- References
- 45
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Matos, J., Blanco, M. G., Maslen, S., Skehel, J. M., & West, S. C. (2011). Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis. Cell. https://doi.org/10.1016/j.cell.2011.08.032
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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