The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Chromatin Insulators: Regulatory Mechanisms and Epigenetic Inheritance
Open accessAbstract
Enhancer-blocking insulators are DNA elements that disrupt the communication between a regulatory sequence, such as an enhancer or a silencer, and a promoter. Insulators participate in both transcriptional regulation and global nuclear organization, two features of chromatin that are thought to be maintained from one generation to the next through epigenetic mechanisms. Furthermore, there are many regulatory mechanisms in place that enhance or hinder insulator activity. These modes of regulation could be used to establish cell-type specific insulator activity that is epigenetically inherited along a cell and/or organismal lineage. This review will discuss the evidence for epigenetic inheritance and regulation of insulator function.
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Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene
Bell, A. C., & Felsenfeld, G. (2000) · Nature · doi:10.1038/35013100 · Cited by 1,746
Cohesin mediates transcriptional insulation by CCCTC-binding factor
Wendt, K. S., Yoshida, K., Itoh, T., Bando, M., Koch, B., Schirghuber, E., Tsutsumi, S., Nagae, G., Ishihara, K., Mishiro, T., et al. (2008) · Nature · doi:10.1038/nature06634 · Cited by 1,193
Murrell, A., Heeson, S., & Reik, W. (2004) · Nature Genetics · doi:10.1038/ng1402 · Cited by 556 · cited 1×
“Additionally, an endogenous example of functional loop formation has been found at the H19 imprinting control region (ICR) in mice, which binds CTCF in an allele-specific manner (Kurukuti et al., 2006; Murrell et al., 2004; Yoon et al., 2007).”
BackgroundCTCF physically links cohesin to chromatin
Rubio, E. D., Reiss, D. J., Welcsh, P. L., Disteche, C. M., Filippova, G. N., Baliga, N. S., Aebersold, R., Ranish, J. A., & Krumm, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801273105 · Cited by 511
Kurukuti, S., Tiwari, V. K., Tavoosidana, G., Pugacheva, E., Murrell, A., Zhao, Z., Lobanenkov, V., Reik, W., & Ohlsson, R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600326103 · Cited by 511
Dorn, R., Krauss, V, Reuter, G., & Saumweber, H. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.23.11376 · Cited by 178 · cited 6×
“PEV was assayed using the In(1)wm4h rearrangement in which the white gene is placed in close proximity to heterochromatin, leading to a variegated eye phenotype owing to varying amounts of heterochromatin spreading and, therefore, varying amounts of white gene expression.”
BackgroundInfluential
Cited by
Verlaan, D. J., Berlivet, S., Hunninghake, G. M., Madore, A.-M., Larivière, M., Moussette, S., Grundberg, E., Kwan, T., Ouimet, M., Ge, B., et al. (2009) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2009.08.007 · Cited by 297
Chen, H., Tian, Y., Shu, W., Bo, X., & Wang, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041374 · Cited by 161
Rohrbaugh, M. C., & Corces, V. G. (2011) · Genetics · doi:10.1534/genetics.111.132126 · Cited by 33
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Metadata
- Authors
- Bushey, A. M., Dorman, E. R., & Corces, V. G.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 32
- Issue
- 1
- Pages
- 1-9
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2152635629
- Cited by
- 209
- References
- 7
- FWCI
- 11.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bushey, A. M., Dorman, E. R., & Corces, V. G. (2008). Chromatin Insulators: Regulatory Mechanisms and Epigenetic Inheritance. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.08.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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