The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

Dorn, R; Krauss, V; Reuter, G; Saumweber, H

doi:10.1073/pnas.90.23.11376

Cited by 178Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromosomal and Genetic Variations

The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

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Dorn, R, Krauss, V, Reuter, G, Saumweber, H·1993·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.90.23.11376PMC PMC47985

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Abstract

In Drosophila modifying mutations of position-effect variegation have been successfully used to genetically dissect chromatin components. The enhancer of position-effect variegation E(var)3-93D [formerly E-var(3)3] encodes proteins containing a domain common to the transcriptional regulators tramtrack and the products of the Broad complex. It interacts with a number of chromatin genes that suppress position-effect variegation. Mutations in E(var)3-93D exhibit an imprinting-like effect on the Y chromosome. This effect is transmitted paternally over several generations. Homeotic transformations in E(var)3-93D mutants indicate an involvement of the gene products in regulation of homeotic gene complexes. An antiserum raised against E(var)3-93D protein detects this chromosomal protein in a large subset of sites in polytene chromosomes. Our genetic and molecular data suggest that the proteins of E(var)3-93D are generally involved in establishing and/or maintaining an open chromatin conformation.

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Authors: Dorn, R., Krauss, V, Reuter, G., & Saumweber, H.
Affiliations: Martin Luther University Halle-Wittenberg (DE)
ORCID: Reuter, G
Saumweber, H
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1993-12
Volume: 90
Issue: 23
Pages: 11376-11380
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.90.23.11376
PMC: PMC47985
OpenAlex: W2084940129
Cited by: 178
References: 20
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 6
FWCI: 4.38
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords: position effect variegation, chromatin proteins, Tramtrack, Broad-Complex, transcription factors, polytene chromosomes, Drosophila
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Chromatin, Cloning, Molecular, DNA Transposable Elements, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Imprinting, Psychological, Molecular Sequence Data, RNA, Messenger, Transcription Factors, Genes, Insect

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The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

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