The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A ncRNA Modulates Histone Modification and mRNA Induction in the Yeast GAL Gene Cluster
Open accessAbstract
Summary The extensively studied yeast GAL1–10 gene cluster is tightly regulated by environmental sugar availability. Unexpectedly, under repressive conditions the 3′ region of the GAL10 coding sequence is trimethylated by Set1 on histone H3 K4, normally characteristic of 5′ regions of actively transcribed genes. This reflects transcription of a long noncoding RNA (GAL10-ncRNA) that is reciprocal to GAL1 and GAL10 mRNAs and driven by the DNA-binding protein Reb1. Point mutations in predicted Reb1-binding sites abolished Reb1 binding and ncRNA synthesis. The GAL10-ncRNA is transcribed approximately once every 50 min and targeted for degradation by the TRAMP and exosome complexes, resulting in low steady-state levels (approximately one molecule per 14 cells). GAL10-ncRNA transcription recruits the methyltransferase Set2 and histone deacetylation activities in cis, leading to stable changes in chromatin structure. These chromatin modifications act principally through the Rpd3S complex to aid glucose repression of GAL1–10 at physiologically relevant sugar concentrations.
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Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
Cawley, S., Bekiranov, S., Ng, H. H., Kapranov, P., Sekinger, E. A., Kampa, D., Piccolboni, A., Sementchenko, V., Cheng, J., Williams, A. J., et al. (2004) · Cell · doi:10.1016/s0092-8674(04)00127-8 · Cited by 1,095
Cited by
Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Batista, P. J., & Chang, H. Y. (2013) · Cell · doi:10.1016/j.cell.2013.02.012 · Cited by 2,531
Long noncoding RNAs: functional surprises from the RNA world
Wilusz, J. E., Sunwoo, H., & Spector, D. L. (2009) · Genes & Development · doi:10.1101/gad.1800909 · Cited by 2,294
Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
Beermann, J., Piccoli, M.-T., Viereck, J., & Thum, T. (2016) · Physiological Reviews · doi:10.1152/physrev.00041.2015 · Cited by 1,726
The Many Pathways of RNA Degradation
Houseley, J., & Tollervey, D. (2009) · Cell · doi:10.1016/j.cell.2009.01.019 · Cited by 1,229
Self-citationZhang, B., Arun, G., Mao, Y. S., Lazar, Z., Hung, G., Bhattacharjee, G., Xiao, X., Booth, C. J., Wu, J., Zhang, C., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.06.003 · Cited by 598
Metadata
- Authors
- Houseley, J., Rubbi, L., Grunstein, M., Tollervey, D., & Vogelauer, M.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 32
- Issue
- 5
- Pages
- 685-695
- ISSN
- 1097-2765 (ISSN-L)
- OpenAlex
- W2041728027
- Cited by
- 293
- References
- 2
- FWCI
- 8.31
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Houseley, J., Rubbi, L., Grunstein, M., Tollervey, D., & Vogelauer, M. (2008). A ncRNA Modulates Histone Modification and mRNA Induction in the Yeast GAL Gene Cluster. Molecular Cell. https://doi.org/10.1016/j.molcel.2008.09.027
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