Long Noncoding RNAs: Cellular Address Codes in Development and Disease
Open accessAbstract
In biology as in real estate, location is a cardinal organizational principle that dictates the accessibility and flow of informational traffic. An essential question in nuclear organization is the nature of the address code--how objects are placed and later searched for and retrieved. Long noncoding RNAs (lncRNAs) have emerged as key components of the address code, allowing protein complexes, genes, and chromosomes to be trafficked to appropriate locations and subject to proper activation and deactivation. lncRNA-based mechanisms control cell fates during development, and their dysregulation underlies some human disorders caused by chromosomal deletions and translocations.
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- Authors
- Batista, P. J., & Chang, H. Y.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Chang, Howard Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 152
- Issue
- 6
- Pages
- 1298-1307
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3651923
- OpenAlex
- W1970741980
- Cited by
- 2,531
- References
- 106
- Citations by year
- 2026: 26 · 2025: 63 · 2024: 124 · 2023: 181 · 2022: 232 · 2021: 304 · 2020: 365 · 2019: 296 · 2018: 266 · 2017: 194 · 2016: 161 · 2015: 153 · 2014: 107 · 2013: 51 · 2012: 2
- FWCI
- 13.05
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- California Institute for Regenerative Medicine
- Damon Runyon Cancer Research Foundation
- California Institute of Regenerative Medicine
- National Institutes of Health
- National Human Genome Research Institute (R01HG004361)
- National Cancer Institute (R01CA118750)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- long non-coding RNA, nuclear organization, chromatin accessibility, gene expression regulation, cell fate specification, development (biology), chromosomal deletion, chromosomal translocation
- MeSH terms
- Animals, Cell Nucleus, Disease, Gene Expression Regulation, Humans, RNA, Long Noncoding
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